Patents by Inventor Nicholas Stamatos

Nicholas Stamatos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of treating inflammation with inhibitors of sialyl transferases
    Publication number: 20060074047
    Abstract: Provided herein are a methods of reducing a level of activity of a sialyl transferase enzyme, a sialidase enzyme or a combination thereof using inhibitors of these enzymes, for example specific inhibitory compound or antibodies directed against the enzymes. The methods are effective to treat an inflammatory disease or disorder or a primary or metastatic cancer. Also provided is a method for screening potential inhibitors of sialyl transferase enzymes.
    Type: Application
    Filed: October 6, 2005
    Publication date: April 6, 2006
    Inventors: Alan Cross, Nicholas Stamatos, Simeon Goldblum
  • Use of antibodies to sialidase as anti-infectious agents and anti-inflammatory agents
    Patent number: 6066323
    Abstract: Sialic acids have the ability to prevent hyposialylation of cells as comptive inhibitors of endogenous sialidase. It is now also possible to develop antibodies to mammalian sialidase that significantly reduce influx of neutrophils into inflammatory sites.
    Type: Grant
    Filed: October 23, 1996
    Date of Patent: May 23, 2000
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Alan S. Cross, Nicholas Stamatos, Peter Gomatos
  • Use of sialic acid or antibodies to sialidase as anti-infectious agents and anti-inflammatory agents
    Patent number: 5631283
    Abstract: The administration of sialidase inhibitors or sialic acid is useful as me for treating inflammatory conditions and for intervening in infectious processes in instances where pathogenicity of the disease-causing organism is increased by microbial surface interaction with host cells.
    Type: Grant
    Filed: February 2, 1994
    Date of Patent: May 20, 1997
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Alan S. Cross, Daniel G. Wright, Peter Gomatos, Nicholas Stamatos