Abstract: The present invention is directed to a method of use of triazolo-pyridazine compounds in the treatment of neuropathic pain. The present invention is also directed to the use of triazolo-pyridazine compounds in the treatment of psychiatric and mood disorders such as, for example, schizophrenia, anxiety, depression, bipolar disorders, and panic, as well as in the treatment of pain, Parkinson's disease, cognitive dysfunction, epilepsy, circadian rhythm and sleep disorders—such as shift-work induced sleep disorder and jet-lag, drug addiction, drug abuse, drug withdrawal and other diseases. The present invention is also directed to novel triazolo-pyridazine compounds that selectively bind to ?2?-1 subunit of Ca channels.

Abstract: A mobile wireless communications device is switchable between a plurality of wireless communications operating modes and may include an antenna, a wireless transceiver connected to the antenna, a first memory for storing a respective compressed file for each of the plurality of wireless communications operating modes, and a second memory having a faster access speed than the first memory. The device may further include a processor connected to the wireless transceiver, the first memory, and the second memory for copying the compressed files from the first memory to the second memory, uncompressing a selected one of the compressed files to generate and store a selected compressed file in the second memory, and processing the selected uncompressed file from the second memory and controlling the wireless transceiver based thereon.

Abstract: A software-defined radio includes a pair of radio subsystems such as a red (command) and black (data) radio subsystem having an operating environment conforming to the Software Communications Architecture (SCA) specification, for example, as used for Joint Tactical Radio System (JTRS). A clock is read by at least one of the radio subsystems for determining time of day. A processor of the radio subsystem is operative for distributing the time of day to the radio subsystems using a global hardware timing pulse. Each processor can include a free-running timer to which any time sources within the pair of radio subsystems are set.

Abstract: A readhead for illuminating a sample carrier and receiving light from the sample carrier, including a housing for receiving a sample carrier, an array of light sources mounted within the housing in a fixed position relative to the sample carrier, and including first and second light-emitting diodes for emitting substantially monochromatic light of a two different wavelengths, a light guide mounted in the housing between the light-emitting diodes and the sample carrier, and a light detector coupled to receive light from the sample carrier. The readhead also includes a light source for directing excitation light of a predetermined wavelength to the sample carrier, and a light filter positioned between the sample carrier and the light detector and adapted to prevent passage therethrough of the excitation light. The readhead allows both fluorescence spectroscopy and reflectance spectroscopy to be conducted on the sample carrier.

Abstract: Disclosed are water soluble compounds which are useful as prodrugs of COX-2 inhibitors, and pharmaceutical compositions comprising them.

Abstract: The present invention encompasses compounds of Formula I (I) or pharmaceutically acceptable salts thereof, wherein A is the base molecule of a propionic acid or acetic acid NSAID, or a derivative thereof, X is —CO2H, 1H-tetrazol-5-yl or 2H-tetrazol-5-yl and R1 and R2 are each independently selected from the group consisting of: C1-6alkyl and C3-6cycloalkyl, as well as pharmaceutical composition comprising said compounds and methods of using said compounds. The compounds of the present invention lower the level of A?42 and are therefore useful for preventing, delaying or reversing the progression of Alzheimer s Disease.

Abstract: A readhead for a photometric diagnostic instrument includes a housing adapted for incorporation within the photometric diagnostic instrument, and an elongated sample table operatively engaged with the housing. The sample table is configured to support elongated reagent sample media of the type having a plurality of test areas disposed in spaced relation thereon, each of the test areas being configured to react with a sample and to change color according to an amount of a constituent or property in the sample. A light source is provided to illuminate the sample table. An imager having an elongated field of view is coupled to the housing, the elongated field of view including at least a portion of the sample table. A scanning mechanism is configured to move the field of view relative to the sample table.