Patents by Inventor Nicholas TECENO

Nicholas TECENO has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ENHANCED DIFFERENTIATION OF PANCREATIC ISLET CELLS
    Publication number: 20260028591
    Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.
    Type: Application
    Filed: October 1, 2025
    Publication date: January 29, 2026
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Chunhui Xie, George Harb, Elizabeth Ryu, Nicholas Teceno, Christopher Farrar, Bryce W. Carey
  • ENHANCED DIFFERENTIATION OF PANCREATIC ISLET CELLS
    Publication number: 20260022345
    Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.
    Type: Application
    Filed: October 1, 2025
    Publication date: January 22, 2026
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Chunhui Xie, George Harb, Elizabeth Ryu, Nicholas Teceno, Christopher Farrar, Bryce W. Carey
  • ENHANCED DIFFERENTIATION OF PANCREATIC ISLET CELLS
    Publication number: 20250243464
    Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic islet cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of treatment making use thereof.
    Type: Application
    Filed: March 5, 2025
    Publication date: July 31, 2025
    Applicant: Vertex Pharmaceuticals Incorporated
    Inventors: Chunhui Xie, George Harb, Elizabeth Ryu, Nicholas Teceno, Christopher Farrar, Bryce W. Carey
  • STEM CELL DIFFERENTIATION AND CHEMICAL COMPOUNDS
    Publication number: 20240358767
    Abstract: Disclosed herein are compositions and methods related to differentiation of stem cells into pancreatic cells. In some aspects, the methods provided herein relate to generation of pancreatic ? cell, ? cell, ? cells, and EC cells in vitro in the presence of one or more chemical compounds that inhibit PI3K/Akt/mTOR signaling. In some aspects, the disclosure provides pharmaceutical compositions including the cells generated according to the methods disclosed herein, as well as methods of making use thereof.
    Type: Application
    Filed: November 7, 2022
    Publication date: October 31, 2024
    Applicant: VERTEX PHARMACEUTICALS INCORPORATED
    Inventors: Chunhui XIE, George HARB, Elizabeth RYU, Nicholas TECENO, Christopher FARRAR