Abstract: Engineered Influenza polynucleotides, viruses, vaccines, and methods of making and using the same are provided. More specifically, the present inventors have developed replication competent engineered influenza viruses having, for example, a modified segment 4 and/or segment 6 that include at least one additional polynucleotide encoding a heterologous polypeptide.

Abstract: A revision connector that is configured to couple a new spine fixation rod to a previously implanted spine fixation rod that is secured to a plurality of vertebrae. The previously implanted spine fixation rod may be received in a first rod receiving channel of the revision connector. The revision connector may include a linkage that is received in a second rod receiving channel of another revision connector. For example, the another revision connector may couple to the new spine fixation rod such that the revision connector is coupled to the new fixation rod. A bone anchor may not directly connect either of the revision connector or the another revision connector to underlying vertebra. Also, the new spine fixation rod can be implanted and secured to vertebra that are caudal and/or cranial with respect to the previously secured vertebrae.

Abstract: A medical robot system, including a robot coupled to an effectuator element with the robot configured for controlled movement and positioning. The system may include a transmitter configured to emit one or more signals, and the transmitter is coupled to an instrument coupled to the effectuator element. The system may further include a motor assembly coupled to the robot and a plurality of receivers configured to receive the one or more signals emitted by the transmitter. A control unit is coupled to the motor assembly and the plurality of receivers, and the control unit is configured to supply one or more instruction signals to the motor assembly.

Abstract: A revision connector that is configured to couple a new spine fixation rod to a previously implanted spine fixation rod that is secured to a plurality of vertebrae. The previously implanted spine fixation rod may be received in a first rod receiving channel of the revision connector. The revision connector may include a linkage that is received in a second rod receiving channel of another revision connector. For example, the another revision connector may couple to the new spine fixation rod such that the revision connector is coupled to the new fixation rod. A bone anchor may not directly connect either of the revision connector or the another revision connector to underlying vertebra. Also, the new spine fixation rod can be implanted and secured to vertebra that are caudal and/or cranial with respect to the previously secured vertebrae.

Abstract: Disclosed are systems and methods that provide a novel framework related to a dynamic spinal assessment tool that provides actionable metrics to guide data-driven, personalized treatment for Adult Spinal Deformity (ASD) and other degenerative spine conditions. The disclosed assessment tool, while worn and/or associated with a patient, can collect physiological patient data for a predetermined period of time, whereby decision-based intelligence software can process the collected data into actionable clinical reports. The dynamically and automatically generated reports, which can be embodied as a digital and/or data structure record of the collected data and/or computational analysis based therefrom, can provide medical professionals (e.g., physicians) with dynamic, patient-specific information for preoperative, intra-operative and/or post-operative stages/procedures.

Abstract: An elongate ultrasonic dissector-shaver probe has a laterally enlarged head extending distally and transversely from a distal end of a shaft and provided with sets of spiraling ribs. In a disc space preparation procedure, the probe is inserted into a spinal disc between two vertebral endplates, ultrasonic vibratory energy is conducted into the probe, and the probe is manipulated to move the laterally enlarged head in three spatial directions within the spinal disc to thereby disrupt and shred the spinal disc material into fragments extracted from the space, in part by suction and in part by using forceps to pull spinal disc fragments from the operative space or surgical site between the vertebral endplates.

Abstract: Embodiments of the present disclosure provide a surgical robot system may include an end-effector element configured for controlled movement and positioning and tracking of surgical instruments and objects relative to an image of a patient's anatomical structure. In some embodiments the end-effector may be tracked by surgical robot system and displayed to a user. In some embodiments the end-effector element may be configured to restrict the movement of an instrument assembly in a guide tube. In some embodiments, the end-effector may contain structures to allow for magnetic coupling to a robot arm and/or wireless powering of the end-effector element. In some embodiments, tracking of a target anatomical structure and objects, both in a navigation space and an image space, may be provided by a dynamic reference base located at a position away from the target anatomical structure.

Abstract: System and method for automatically bending a surgical rod are provided. The system includes a linear movement device configured to axially feed the surgical rod, a rotational movement device configured to rotate the surgical rod as it is axially fed, and a bending device including a roller to impose bending forces against the rod. The rod is free from contact with the bending device after it is axially fed past the roller.

Abstract: A method for bending a surgical rod using an automated bending system includes receiving an indication of a plurality of line segments defined on the rod and an indication of an angle measurement to be formed between at least two adjacent ones of the plurality of line segments. Bending parameters to perform on the rod to form the angle measurement between the at least two adjacent ones of the plurality of line segments are determined and operation of the automated bending system is controlled using the bending parameters to create an angle having the angle measurement between the at least two adjacent ones of the plurality of line segments.

Abstract: A medical robot system, including a robot coupled to an effectuator element with the robot configured for controlled movement and positioning. The system may include a transmitter configured to emit one or more signals, and the transmitter is coupled to an instrument coupled to the effectuator element. The system may further include a motor assembly coupled to the robot and a plurality of receivers configured to receive the one or more signals emitted by the transmitter. A control unit is coupled to the motor assembly and the plurality of receivers, and the control unit is configured to supply one or more instruction signals to the motor assembly.

Abstract: Provided herein are systems and methods for monitoring and treatment of an injury. The system includes a control device, an implantable device and/or a wearable device, the implantable device configured to be implanted into a body, the implantable device having a sensing device for sensing a condition of the injury and a treatment device configured to apply a treatment to the injury based on the sensed conditions of the injury. Signals of the sensed condition are sent to the control device, and the control device controls the treatment device of the implantable device to apply treatment for the injury. When a wearable device is included, the wearable device may be configured to sense another condition related to the injury and send signal indicative thereof to the control device.

Abstract: An implant includes a cannula. The cannula defines an axial drainage bore and a plurality of radial openings providing a path of fluid communication between an exterior of the cannula and the axial drainage bore to drain fluid. The implant also includes a first sensor positioned at least partially in the cannula. The first sensor is configured to measure a biomarker in the fluid. The implant also includes a second sensor positioned at least partially in the cannula. The second sensor is configured to measure a pressure of the fluid. The implant also includes a third sensor positioned at least partially in the cannula. The third sensor is configured to measure a temperature of the fluid.

Abstract: Systems and methods for user personalization and recommendation schemes that are matched to a user profile and provide a highly personalized, interactive experience for the user on an entertainment platform are disclosed. In one aspect of the invention, the highly personalized and interactive experience is facilitated through information from the user profile comprised of user-inputted information, historical data, and outputs from machine learning engines. In another aspect of the invention, the system is capable of outputting the highly-personalized and interactive recommendations onto a viewing screen while media content is continuously streaming on the same viewing screen.

Abstract: Provided herein are medical devices, systems, and methods for monitoring and treating injuries, diseases, or other conditions in patients. The medical devices include body structures that comprise an imaging array, a stimulation array, and an electrode array. The medical devices are implantable in patients in some embodiments.

Abstract: A patient monitoring and/or treatment system and method is disclosed. The system includes a wearable device configured to be wearable on an external portion of a patient. The wearable device configured to monitor and/or treat a biological feature of the patient, the wearable device including: one or more ultrasonic transmitters that provide ultrasonic energy to a monitoring site and/or a treatment site of the patient; one or more ultrasonic receivers that receive reflected ultrasonic energy from the monitoring site and/or the treatment site; and a controller that controls the one or more ultrasonic transmitter and the one or more ultrasonic receivers and determines an attribute of the biological feature based on the ultrasonic energy that is provided and the ultrasonic energy that is received.

Abstract: Embodiments are directed to a medical robot system including a robot coupled to an end-effectuator element with the robot configured to control movement and positioning of the end-effectuator in relation to the patient. One embodiment is a method for removing bone with a robot system comprising: taking a two-dimensional slice through a computed tomography scan volume of target anatomy; placing a perimeter on a pathway to the target anatomy; and controlling a drill assembly with the robot system to remove bone along the pathway in the intersection of the perimeter and the two-dimensional slice.

Abstract: Embodiments are directed to a medical robot system including a robot coupled to an end-effectuator element with the robot configured to control movement and positioning of the end-effectuator in relation to the patient. One embodiment is a method for removing bone with a robot system comprising: taking a two-dimensional slice through a computed tomography scan volume of target anatomy; placing a perimeter on a pathway to the target anatomy; and controlling a drill assembly with the robot system to remove bone along the pathway in the intersection of the perimeter and the two-dimensional slice.

Abstract: Devices and methods for temporarily affixing a surgical apparatus to a bony structure. The temporary mount includes a base member having a top face configured to be impacted by an insertion device and a plurality of elongated prongs extending downwardly from the base member and configured to engage a bony structure. The prongs are separated a distance from one another, and the prongs are configured to move inwardly toward one another when driven downward into the bony structure.

Abstract: Systems and methods for user personalization and recommendation schemes that are matched to a user profile and provide a highly personalized, interactive experience for the user on an entertainment platform are disclosed. In one aspect of the invention, the highly personalized and interactive experience is facilitated through information from the user profile comprised of user-inputted information, historical data, and outputs from machine learning engines. In another aspect of the invention, the system is capable of outputting the highly-personalized and interactive recommendations onto a viewing screen while media content is continuously streaming on the same viewing screen.

Abstract: Embodiments are directed to a medical robot system including a robot coupled to an end-effectuator element with the robot configured to control movement and positioning of the end-effectuator in relation to the patient. One embodiment is a method for removing bone with a robot system comprising: taking a two-dimensional slice through a computed tomography scan volume of target anatomy; placing a perimeter on a pathway to the target anatomy; and controlling a drill assembly with the robot system to remove bone along the pathway in the intersection of the perimeter and the two-dimensional slice.