Abstract: The present disclosure is directed to N-(3-substituted-chroman-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine compounds, methods of making N-(3-substituted-chroman-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine compounds, and methods of treating disorders associated with PINK1 kinase activity including, but not limited to, neurodegenerative diseases, mitochondrial diseases, fibrosis, and/or cardiomyopathy using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Described are systems and methods for measuring the similarity of security alerts, security incidents, or other complex data structures at scale using machine-learned signature vectors suitable for efficient similarity-based filtering in conjunction with hashes of the security alerts for more detailed comparisons. In some embodiments, similarity measurements between security incidents are used to base the processing of a current security incident on similar prior security incidents.

Abstract: A client device receives a challenge request from a server to prove that internet traffic was initiated by a human user through verifying a physical interaction between a human user and a hardware component. The client device causes a prompt to be displayed to perform the physical interaction with the hardware component. A cryptographic attestation is received that includes an attestation signature that is generated after confirmation that the physical interaction was performed with the hardware component. A zero-knowledge proof of the attestation signature is generated and transmitted to the server for verification. The client device receives the requested content responsive to the server verifying the validity of the zero-knowledge proof.

Abstract: Epoxy-based adhesive compositions are provided, exhibiting improved uncured humidity resistance, cured humidity resistance and improved wash-off resistance, which upon curing result in crash durable and stress resistant cured bonds on steel and low surface tension surfaces, e.g. ZnMgAl, hot dipped galvanized (HDG) and treated aluminum surfaces. Also provided are bonded assemblies comprising pre-cure or fully cured epoxy-based adhesives, methods of making the epoxy-based adhesives, methods of bonding assemblies and articles of manufacture comprising the bonded assemblies.

Abstract: The present disclosure is directed to N-containing heteroaryl analogs, methods of making N-containing heteroaryl analogs, and methods of treating kidney diseases, fibrotic disorders, and reperfusion injuries using these analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

Abstract: The present disclosure is directed to N—(3-substituted-chroman-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine compounds, methods of making N—(3-substituted-chroman-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine compounds, and methods of treating disorders associated with PINK kinase activity including, but not limited to, neurodegenerative diseases, mitochondrial diseases, fibrosis, and/or cardiomyopathy using these compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: A compound receiver receives radio-frequency electromagnetic or other propagating radiation. A filter generates a filtered electrical signal representing at least one selected electromagnetic signal isolated from a monitored electrical signal. A transmitter retransmits, with a specified timing, the selected electromagnetic signal or signals represented within the filtered electrical signal. A protected receiver receives a combination of the electromagnetic signals and the selected electromagnetic signal or signals retransmitted from the transmitter. The protected receiver generates a detected electrical signal representing the combination. A relative position sensor adjusts the specified timing to suppress or cancel the selected electromagnetic signal or signals represented within the detected electrical signal.

Abstract: A storage system receives a command from a host to overwrite data that is stored in a memory of the storage system. The command may have been issued in error or by malware, so the storage system preserves the data that the host wants to overwrite, just in case the host later wants to recover the data. To do this, the storage system associates the physical address of the location of the memory that stores the data with a logical block address that is inaccessible by the host. To recover the data, the storage system replaces the logical block address that is inaccessible by the host with a logical block address that is accessible by the host.

Abstract: Provided herein is technology relating to functional microbial consortia and particularly, but not exclusively, to methods and systems for producing a microbial consortium possessing a desired function and microbial consortia produced according to such methods. The microbial consortia may be used to improve soil, e.g., for agricultural uses.

Abstract: The present disclosure is directed to adenine analogs, methods of making adenine analogs, and methods of treating disorders associated with PINK1 kinase activity including, but not limited to, neurodegenerative diseases, mitochondrial diseases, fibrosis, and/or cardiomyopathy using these analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

Abstract: Liquid epoxy-based adhesive compositions are provided, which upon curing result in crash durable and stress resistant cured bonds on both steel and other materials, in particular metals such as aluminum; and in some embodiments are weldable in an uncured state; also provided are bonded assemblies comprising the cured epoxy-based adhesives, methods of making the liquid epoxy-based adhesives, methods of bonding assemblies and articles of manufacture comprising the bonded assemblies.