Abstract: The present invention provides for the treatment of primary headache disorders, particularly migraine, using antagonists of the EP4 receptor for prostaglandin E2. Particular EP4 receptor antagonists include azole compounds of formula (I): wherein R1 is a group such as lower alkyl substituted with carboxy; R2 is hydrogen or lower alkyl, R3 and R4 are aryl optionally substituted with halogen, Q is in which -A1- is a single bond or lower alkylene, is a cyclo group, -A3- is a single bond or lower alkylene, and X is O, NH or S; or a salt or its solvate thereof.

Abstract: The present invention provides for the treatment of primary headache disorders, particularly migraine, using antagonists of the EP4 receptor for prostaglandin E2. Particular EP4 receptor antagonists include azole compounds of formula (I): wherein R1 is a group such as lower alkyl substituted with carboxy; R2 is hydrogen or lower alkyl, R3 and R4 are aryl optionally substituted with halogen, Q is in which -A1- is a single bond or lower alkylene, is a cyclo group, -A3- is a single bond or lower alkylene, and X is O, NH or S; or a salt or its solvate thereof.

Abstract: The invention relates to the structure of an upper ontology and a system and method for utilizing an upper ontology in the creation of one or more multi-relational ontologies. The invention includes an upper ontology of predefined concept and relationship types, and a predefined set or relationships that may be used to connect particular pairs of concepts. The concept and relationship types may be dictated by the knowledge domains in which the resultant ontology is to reside. The invention may also include a hierarchy of concept types wherein the relationships that may exist between concept types is specified.

Abstract: The invention relates generally to a system and method for creating one or more structured multi-relational ontologies. The invention may include ontologies comprising assertions made up of concept-relationship-concept triplets. The invention may also include predefined sets of concept and relationship types as well as concept type hierarchies and concept-relationship association parameters. The invention may further include properties as concepts, synonyms of concepts as concepts, and documents or parts thereof as concepts.

Abstract: The invention relates to a system and method for knowledge capture using multi-relational ontologies. The system may enable an ontology service provider to ascertain the scope of an entity's knowledge capture needs, create one or more base ontologies from publicly available sources, and incorporate the entity's private data into one or more value-added custom ontologies.

Abstract: The invention relates to a system and method for the enrichment and curation of concept, relationship, and assertion information into a multi-relational ontology. The invention includes a system enabling a curator, or other person, to verify the validity of assertions created by predetermined rules. The curator may also manually edit, delete, or add assertions to an ontology.

Abstract: The present invention provides for the treatment of primary headache disorders, particularly migraine, using antagonists of the EP4 receptor for prostaglandin E2.