Patents by Inventor Nicholas W. Shworak

Nicholas W. Shworak has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Mouse model of myxomatous valvular disease
    Patent number: 7166763
    Abstract: An animal selected for lacking heparan sulfate 3-O-sulfotransferase-1 activity is provided. This animal exhibits characteristics associated with myxomatous valvular disease and is useful for identifying agents which prevent, delay or treat myxomatous valvular disease. Methods of diagnosing myxomatous valvular disease are also provided.
    Type: Grant
    Filed: February 10, 2003
    Date of Patent: January 23, 2007
    Assignees: Trustees of Dartmouth College, Massachusetts Institute of Technology (MIT)
    Inventors: Nicholas W. Shworak, Robert D. Rosenberg, Robert T. Palac
  • Heparan sulfate D-glucosaminyl 3-O-sulfotransferases, and uses therefor
    Patent number: 6861254
    Abstract: Disclosed are novel isolated nucleic acids and substantially pure protein preparations for naturally occurring and synthetic or chimeric heparan sulfate D-glicosaminyl 3-O-sulfo-transferases (3-OSTs). Also disclosed are uses for these genes and proteins, including uses for the modification and sequencing of glycosaminoglycans.
    Type: Grant
    Filed: April 24, 2000
    Date of Patent: March 1, 2005
    Assignee: Massachusetts Institute of Technology
    Inventors: Robert D. Rosenberg, Nicholas W. Shworak, Jian Liu, Linda M. S. Fritze, John J. Schwartz, Lijuan Zhang
  • Animal selected for lacking heparan sulfate 3-0-sulfotransferase-1 and uses thereof
    Publication number: 20040158881
    Abstract: An animal selected for lacking heparan sulfate 3-O-sulfotransferase-1 activity is provided. This animal exhibits characteristics associated with myxomatous valvular disease and is useful for identifying agents which prevent, delay or treat myxomatous valvular disease. Methods of diagnosing myxomatous valvular disease are also provided.
    Type: Application
    Filed: February 10, 2003
    Publication date: August 12, 2004
    Inventors: Nicholas W. Shworak, Robert D. Rosenberg, Robert T. Palac