Abstract: A clinical trial operations system includes: patient, clinician, and coordinator applications; a patient sensor that provides health measurements through the patient application; a clinical sensor that provides in-office health measurements through the clinician application; and a trial operations service suite that receives and analyzes data from the patient application, the clinician application, and the coordinator application and provides data to the patient application, the clinician application, and the coordinator application via a set of portals including a patient portal, a clinician portal, and a coordinator portal, where the coordinator application and the coordinator portal allow a coordinator user to develop, build, customize, and establish trial protocol and participant interaction.

Abstract: A trial operations service suite in a clinical trial operations system includes: patient, clinician, investigator, and coordinator portals supporting corresponding applications and providing specific services for each type of participant, where the coordinator portal allows a coordinator user to develop, build, customize, and establish trial protocol and participant interaction using an application factory system embedded within a trial design aspect of the coordinator portal; security configuration and management authentication databases; operational databases including trial data including provisioning and authorization data describing trial participants, access logs recording participant activity, protected and de-identified health information and/or non-health provided by patients, clinicians, and associated sensors; a notification relay service and corresponding external notifications gateway providing essential communication between the system and users, between clinicians and patients, and between coor

Abstract: An hydrogel incorporating a biologically active component is provided that is useful as an interface material for transdermal sensing applications. Specifically, the hydrogel has a crosslinked gel structure and a biologically active component incorporated into the crosslinked gel structure, the biologically active component being capable of converting glucose into a compound having potentiometric activity.

Abstract: The invention according to an exemplary embodiment relates to a method for transporting a substance across a biological membrane comprising the steps of applying a delipidation agent to a portion of the biological membrane, applying a hydration agent to the portion of the biological membrane, sonicating the portion of the biological membrane, and transporting the substance across the biological membrane. The step of applying the delipidation agent may be carried out prior to or simultaneously with the step of applying the hydration agent. The hydration agent may be applied before, during, or after the sonication step. The methods according to exemplary embodiments of the invention can provide improved transdermal transport in applications such as continuous analyte extraction and analysis and transdermal delivery of drugs and vaccines.

Abstract: A microdrive apparatus useful in human stereotactic surgery is disclosed. Such apparatus permits safe and accurate placement of a surgical instrument, such as a cannula, into a portion of the central nervous system, e.g. the brain and spinal cord, of a patient by simple mechanical operation.

Abstract: The present invention is directed to microdrive apparatus useful in human stereotactic surgery. Such apparatus permits safe and accurate placement of a surgical instrument, such as a cannula, into a portion of the central nervous system, e.g. the brain and spinal cord, of a patient by simple mechanical operation.