Abstract: Aspects relate to patterned nanostructures having a feature size not including film thickness of below 5 microns. The patterned nanostructures are made up of nanoparticles having an average particle size of less than 100 nm. A nanoparticle composition, which, in some cases, includes a binder, is applied to a substrate. A patterned mold used in concert with electromagnetic radiation function to manipulate the nanoparticle composition in forming the patterned nanostructure. In some embodiments, the patterned mold nanoimprints a pattern onto the nanoparticle composition and the composition is cured through UV or thermal energy. Three-dimensional patterned nanostructures may be formed. A number of patterned nanostructure layers may be prepared and joined together. In some cases, a patterned nanostructure may be formed as a layer that is releasable from the substrate upon which it is initially formed.

Abstract: A tube includes a layer including a polymer matrix and a refractive index domain dispersed within the polymer matrix, wherein the refractive index domain has a refractive index less than a refractive index of the polymer matrix, the layer having a refractive index of less than 1.42.

Abstract: A method of forming the composite body can comprise forming a first extrudate and a second extrudate, wherein the first extrudate comprises an organic polymer and ceramic particles, the ceramic particles including hexagonal boron nitride (hBN) particles; combining the first extrudate and the second extrudate to form a composite body including two layers; conducting a layer multiplying procedure on the composite body, the layer multiplying procedure comprising dividing and recombining the composite body to form a multi-layer composite body.

Abstract: A composite article can comprise a composite body including an organic polymer and ceramic particles comprising hexagonal boron nitride (hBN) particles distributed throughout the organic polymer, wherein an amount of the hBN particles ranges from 20 vol % to 40 vol % based on a total volume of the body; and the body comprises an in plane thermal conductivity of at least 10 W/mK. The hBN particles within the composite body can have a March-Dollase Orientation parameter ? of at least 50%.

Abstract: A composite article can comprise a composite body including an organic polymer and ceramic particles comprising hexagonal boron nitride (hBN) particles distributed throughout the organic polymer, wherein an amount of the hBN particles ranges from 40 vol % to 90 vol % based on a total volume of the body; and the body comprises an in plane thermal conductivity of at least 15 W/mK. The hBN particles within the composite body can have a March-Dollase Orientation parameter ? of at least 50%.

Abstract: Devices, techniques, and processes are disclosed that use electrical impedance to detect of the presence and contents of droplets including cells, nucleic acids, proteins, or solute concentrations in an array of retrievable, trackable, trapped droplets in a fluidic system. Electrodes may be positioned underneath individual droplet traps in a microchannel to assay droplet contents and/or actuating droplets for the release of the droplets from corresponding traps.

Abstract: Devices, techniques, and processes are disclosed that use electrical impedance to detect of the presence and contents of droplets including cells, nucleic acids, proteins, or solute concentrations in an array of retrievable, trackable, trapped droplets in a fluidic system. Electrodes may be positioned underneath individual droplet traps in a microchannel to assay droplet contents and/or actuating droplets for the release of the droplets from corresponding traps.

Abstract: A sample-to-answer microfluidic system and method including vertical microfluidic device and automated actuation mechanisms, such as, but not limited to, automated mechanical and/or magnetic actuation, is disclosed. In some embodiments, the sample-to-answer microfluidic system includes a vertically oriented microfluidic device and a rotating actuator in relation to the microfluidic device, and wherein the microfluidic device and the rotating actuator are operating in the XZ plane. Additionally, methods of using the sample-to-answer microfluidic system are provided.

Abstract: Devices, techniques, and processes are disclosed that use electrical impedance to detect of the presence and contents of droplets including cells, nucleic acids, proteins, or solute concentrations in an array of retrievable, trackable, trapped droplets in a fluidic system. Electrodes may be positioned underneath individual droplet traps in a microchannel to assay droplet contents and/or actuating droplets for the release of the droplets from corresponding traps.

Abstract: This disclosure relates to methods and devices to count particles of interest, such as cells. The methods include obtaining a fluid sample that may contain particles of interest; counting all types of particles in a portion of the sample using a first electrical differential counter to generate a first total; removing any particles of interest from the portion of the fluid sample; counting any particles remaining in the portion of the fluid sample using a second electrical differential counter after the particles of interest are removed to generate a second total; and calculating a number of particles of interest originally in the fluid sample by subtracting the second total from the first total, wherein the difference is the number of particles of interest in the sample. These methods and related devices can be used, for example, to produce a robust, inexpensive diagnostic kit for CD4+ T cell counting in whole blood samples.

Abstract: A pop-up external lens washing system has an extendable aiming fixture configured to aim a lens cleaning spray at an external lens which is exposed to the elements and apt to become soiled with debris. The extendable nozzle assembly is configured to be aimed toward the external lens by the extended aiming fixture during the washing operation only and has at least one laterally offset washing nozzle projecting from the aiming fixture to a spray washing fluid toward the external lens surface, spraying at a shallow, glancing spray aiming angle to impinge upon and wash the lens external surface.

Abstract: This disclosure relates to methods and devices to count particles of interest, such as cells. The methods include obtaining a fluid sample that may contain particles of interest; counting all types of particles in a portion of the sample using a first electrical differential counter to generate a first total; removing any particles of interest from the portion of the fluid sample; counting any particles remaining in the portion of the fluid sample using a second electrical differential counter after the particles of interest are removed to generate a second total; and calculating a number of particles of interest originally in the fluid sample by subtracting the second total from the first total, wherein the difference is the number of particles of interest in the sample. These methods and related devices can be used, for example, to produce a robust, inexpensive diagnostic kit for CD4+ T cell counting in whole blood samples.

Abstract: A pop-up external lens washing system has an extendable aiming fixture configured to aim a lens cleaning spray at an external lens which is exposed to the elements and apt to become soiled with debris. The extendable nozzle assembly is configured to be aimed toward the external lens by the extended aiming fixture during the washing operation only and has at least one laterally offset washing nozzle projecting from the aiming fixture to a spray washing fluid toward the external lens surface, spraying at a shallow, glancing spray aiming angle to impinge upon and wash the lens external surface.

Abstract: This disclosure relates to methods and devices to count particles of interest, such as cells. The methods include obtaining a fluid sample that may contain particles of interest; counting all types of particles in a portion of the sample using a first electrical differential counter to generate a first total; removing any particles of interest from the portion of the fluid sample; counting any particles remaining in the portion of the fluid sample using a second electrical differential counter after the particles of interest are removed to generate a second total; and calculating a number of particles of interest originally in the fluid sample by subtracting the second total from the first total, wherein the difference is the number of particles of interest in the sample. These methods and related devices can be used, for example, to produce a robust, inexpensive diagnostic kit for CD4+ T cell counting in whole blood samples.

Abstract: This disclosure relates to methods and devices to count particles of interest, such as cells. The methods include obtaining a fluid sample that may contain particles of interest; counting all types of particles in a portion of the sample using a first electrical differential counter to generate a first total; removing any particles of interest from the portion of the fluid sample; counting any particles remaining in the portion of the fluid sample using a second electrical differential counter after the particles of interest are removed to generate a second total; and calculating a number of particles of interest originally in the fluid sample by subtracting the second total from the first total, wherein the difference is the number of particles of interest in the sample. These methods and related devices can be used, for example, to produce a robust, inexpensive diagnostic kit for CD4+ T cell counting in whole blood samples.

Abstract: In one embodiment, a method includes discovering a resource using a first discovery module, the first discovery module being for identifying resources having identifying information known to the first discovery module. The method also includes discovering the resource using a second discovery module, the second discovery module being for identifying resources having identifying information not known to the first discovery module. An object associated with the resource is created by the first discovery module if the resource has identifying information known to the first discovery module. In addition, an object associated with the resource is created by the second discovery module if the resource has identifying information not known to the first discovery module.

Abstract: In one embodiment, a method includes discovering a resource using a first discovery module, the first discovery module being for identifying resources having identifying information known to the first discovery module. The method also includes discovering the resource using a second discovery module, the second discovery module being for identifying resources having identifying information not known to the first discovery module. An object associated with the resource is created by the first discovery module if the resource has identifying information known to the first discovery module. In addition, an object associated with the resource is created by the second discovery module if the resource has identifying information not known to the first discovery module.

Abstract: This invention relates to recombinant GPIIIa molecules that lack the ligand binding ?A domain and bind to HPA-1 antibodies in monomeric form. These GPIIIa molecules can be recombinantly expressed at high levels and may be useful, for example, in the detection of HPA-1 antibodies. Such detection may be useful, for example, in the diagnosis and therapy of HPA antibody disorders such as Neonatal Alloimmune Immune Thrombocytpenia (NAIT), Post Transfusion Purpura (PTP) and Platelet Refractoriness (PR).

Abstract: Tubing or piping for carrying a multiphase flow is provided with means for inducing swirl flow, such that the denser components of the flow tend to the outer wall of the tubing or piping, and less dense components tend to the center of the tubing or piping. The flow thus exhibits a “centrifuge” effect, which prevents lighter or heavier components of the flow from accumulating in upper or lower regions respectively of the tubing or piping, and reduces the risk of airlocks and the like. Preferably, the tubing or piping is in the form of a helix, which may be a low amplitude helix.

Abstract: A device for placement externally of a body fluid flow conduit, includes a tubing portion defining a longitudinally extending cavity for receiving the conduit. The longitudinal cavity of the tubing portion is substantially free of ribs or grooves. The center line of the longitudinal cavity follows a substantially helical path with a helix angle which is less than or equal to 65°. An amplitude of the helix is less than or equal to one half of the internal diameter of the tubing portion.