Abstract: A system for monitoring autonomic health may include an autonomic nerve stimulation (ANS) dose delivery system and a response extractor. The response extractor may be configured to record physiological parameter values including first population data that includes evoked response (ER) values corresponding to evoked physiological responses, and second population data that includes reference values that include no effect (NE) values corresponding to times without a physiological response. The response monitor may calculate evoked response metrics (ERMs) using the first and second population data where each of the ERMs may be dependent on background autonomic activity. The response extractor may analyze the ERMs to provide ERM analysis, and provide an indication of autonomic health using the ERM analysis.

Abstract: A method may include delivering autonomic neural stimulation (ANS) therapy, including delivering stimulation pulses to evoke physiological responses. The method may further include recording physiological parameter values, including recording first population data, the first population data including evoked response (ER) values corresponding to the evoked physiological responses, and recording second population data, the second population data including reference values that include no effect (NE) values corresponding to times without an evoked physiological response. The method may further include quantifying a relationship between the first population data and the second population data, and analyzing the quantified relationship for a signature to indicate if the stimulation pulses are evoking desired physiological responses.

Abstract: A system for monitoring autonomic health may include an autonomic nerve stimulation (ANS) dose delivery system and a response extractor. The response extractor may be configured to record physiological parameter values including first population data that includes evoked response (ER) values corresponding to evoked physiological responses, and second population data that includes reference values that include no effect (NE) values corresponding to times without a physiological response. The response monitor may calculate evoked response metrics (ERMs) using the first and second population data where each of the ERMs may be dependent on background autonomic activity. The response extractor may analyze the ERMs to provide ERM analysis, and provide an indication of autonomic health using the ERM analysis.

Abstract: A method may include delivering autonomic neural stimulation (ANS) therapy, including delivering stimulation pulses to evoke physiological responses. The method may further include recording physiological parameter values, including recording first population data, the first population data including evoked response (ER) values corresponding to the evoked physiological responses, and recording second population data, the second population data including reference values that include no effect (NE) values corresponding to times without an evoked physiological response. The method may further include quantifying a relationship between the first population data and the second population data, and analyzing the quantified relationship for a signature to indicate if the stimulation pulses are evoking desired physiological responses.