Patents by Inventor Nicholas Wrighton
Nicholas Wrighton has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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NOVEL GENES ENCODING PROTEINS HAVING PROGNOSTIC, DIAGNOSTIC, PREVENTIVE, THERAPEUTIC, AND OTHER USES
Publication number: 20120270219Abstract: The invention provides isolated TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.Type: ApplicationFiled: July 2, 2012Publication date: October 25, 2012Applicant: Millennium Pharmaceuticals, Inc.Inventors: Douglas A. Holtzman, John D. Sharp, Kevin R. Leiby, Steven Bossone, Yang Pan, Thomas M. Barnes, Christopher C. Fraser, Nicholas Wrighton, Paul S. Myers, Gillian Kingsbury -
NOVEL GENES ENCODING PROTEINS HAVING PROGNOSTIC, DIAGNOSTIC, PREVENTIVE, THERAPEUTIC, AND OTHER USES
Publication number: 20120045777Abstract: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.Type: ApplicationFiled: June 27, 2011Publication date: February 23, 2012Applicant: Millennium Pharmaceuticals, Inc.Inventors: Christopher C. Fraser, Thomas M. Barnes, John D. Sharp, Susan J. Kirst, Paul S. Myers, Kevin R. Leiby, Douglas A. Holtzman, Sean A. McCarthy, Nicholas Wrighton, Charles R. Mackay, Andrew D.J. Goodearl -
Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
Publication number: 20110065124Abstract: The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.Type: ApplicationFiled: May 20, 2010Publication date: March 17, 2011Inventors: Douglas A. Holtzman, John D. Sharp, Kevin R. Leiby, Steven Bossone, Yang Pan, Thomas M. Barnes, Christopher C. Fraser, Nicholas Wrighton, Paul S. Myers, Gillian Kingsbury -
Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
Publication number: 20100062487Abstract: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.Type: ApplicationFiled: May 8, 2009Publication date: March 11, 2010Inventors: Christopher C. Fraser, Thomas M. Barnes, John D. Sharp, Susan J. Kirst, Paul S. Myers, Kevin R. Leiby, Douglas A. Holtzman, Sean A. McCarthy, Nicholas Wrighton, Charles R. Mackay, Andrew D.J. Goodearl -
Publication number: 20090136959Abstract: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.Type: ApplicationFiled: October 23, 2008Publication date: May 28, 2009Inventors: Sean A. McCarthy, Christopher C. Fraser, John D. Sharp, Thomas M. Barnes, Susan J. Kirst, Paul S. Myers, Nicholas Wrighton, Andrew D.J. Goodearl, Douglas A. Holtzman, Mehran Khodadoust
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Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
Publication number: 20080213778Abstract: The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.Type: ApplicationFiled: November 8, 2007Publication date: September 4, 2008Inventors: Douglas A. Holtzman, John D. Sharp, Kevin R. Leiby, Steven Bossone, Yang Pan, Thomas M. Barnes, Christopher C. Fraser, Nicholas Wrighton, Paul S. Myers, Gillian Kingsbury -
Publication number: 20070148091Abstract: Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.Type: ApplicationFiled: December 13, 2006Publication date: June 28, 2007Inventors: William Dower, Ronald Barrett, Steven Cwirla, David Duffin, Christian Gates, Sherril Haselden, Larry Mattheakis, Peter Schatz, Christopher Wagstrom, Nicholas Wrighton
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Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
Publication number: 20070048771Abstract: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.Type: ApplicationFiled: July 21, 2006Publication date: March 1, 2007Inventors: Sean McCarthy, Christopher Fraser, John Sharp, Thomas Barnes, Susan Kirst, Paul Myers, Nicholas Wrighton, Andrew Goodearl, Douglas Holtzman, Mehran Khodadoust -
Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
Publication number: 20060216727Abstract: The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.Type: ApplicationFiled: November 23, 2005Publication date: September 28, 2006Inventors: Douglas Holtzman, John Sharp, Kevin Leiby, Steven Bossone, Yang Pan, Thomas Barnes, Christopher Fraser, Nicholas Wrighton, Paul Myers, Gillian Kingsbury -
Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
Publication number: 20060205034Abstract: The invention provides isolated nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.Type: ApplicationFiled: November 2, 2005Publication date: September 14, 2006Inventors: Christopher Fraser, Sean McCarthy, John Sharp, Thomas Barnes, Nicholas Wrighton, Charles Mackay, Kevin Leiby, Douglas Holtzman -
Publication number: 20060058240Abstract: Described are peptides and peptide mimetics that bind to and activate the thrombopoietin receptor. Such peptides and peptide mimetics are useful in methods for treating hematological disorders and particularly, thrombocytopenia resulting from chemotherapy, radiation therapy, or bone marrow transfusions as well as in diagnostic methods employing labeled peptides and peptide mimetics.Type: ApplicationFiled: October 20, 2005Publication date: March 16, 2006Inventors: William Dower, Ronald Barrett, Steven Cwirla, David Duffin, Christian Gates, Sherril Haselden, Larry Mattheakis, Peter Schatz, Christopher Wagstrom, Nicholas Wrighton
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Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
Publication number: 20040121396Abstract: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.Type: ApplicationFiled: December 19, 2003Publication date: June 24, 2004Applicant: Millennium Pharmaceuticals, Inc.Inventors: Christopher C. Fraser, Thomas M. Barnes, John D. Sharp, Susan J. Kirst, Paul S. Myers, Kevin R. Leiby, Douglas A. Holtzman, Sean A. McCarthy, Nicholas Wrighton, Charles R. MacKay, Andrew D.J. Goodearl -
Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
Publication number: 20030170621Abstract: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.Type: ApplicationFiled: January 19, 2001Publication date: September 11, 2003Inventors: Sean A. McCarthy, Christopher C. Fraser, John D. Sharp, Thomas M. Barnes, Susan J. Kirst, Paul S. Myers, Nicholas Wrighton, Andrew D.J. Goodearl, Douglas A. Holtzman, Mehran Khodadoust -
Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
Publication number: 20030022279Abstract: The invention provides isolated nucleic acids encoding a variety of proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods using compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.Type: ApplicationFiled: January 12, 2001Publication date: January 30, 2003Inventors: Christopher C. Fraser, Thomas M. Barnes, John D. Sharp, Susan J. Kirst, Paul S. Myers, Kevin R. Leiby, Douglas A. Holtzman, Sean A. McCarthy, Nicholas Wrighton, Charles R. MacKay, Andrew D.J. Goodearl -
Novel genes encoding proteins having prognostic, diagnostic, preventive, therapeutic, and other uses
Publication number: 20020055139Abstract: The invention provides isolated TANGO 239, TANGO 219, TANGO 232, TANGO 281, A236 (INTERCEPT 236), TANGO 300, TANGO 353, TANGO 393, TANGO 402, TANGO 351 and TANGO 509 nucleic acid molecules and polypeptide molecules. The invention also provides antisense nucleic acid molecules, expression vectors containing the nucleic acid molecules of the invention, host cells into which the expression vectors have been introduced, and non-human transgenic animals in which a nucleic acid molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening and therapeutic methods utilizing compositions of the invention are also provided.Type: ApplicationFiled: March 1, 2001Publication date: May 9, 2002Inventors: Douglas A. Holtzman, John D. Sharp, Kevin R. Leiby, Steven Bossone, Yang Pan, Thomas M. Barnes, Christopher C. Fraser, Nicholas Wrighton, Paul S. Myers, Gillian Kingsbury