Abstract: Disclosed are techniques for stapler reload detection and identification. A manipulator is configured to have an instrument mounted thereto. The instrument includes an end effector configured to receive a replaceable stapler cartridge. An actuator is drivingly coupled with the pusher member. A control unit is configured to control operation of the actuator to move the pusher member from a first position toward a second position; determine a distance that the pusher member moves from the first position toward the second position before a force limit for the actuator is exceeded; and determine, based on the distance that the pusher member moves, an operational status of the instrument relating to the replaceable stapler cartridge.

Abstract: Various examples herein described are directed to methods, apparatuses, and computer program products for implementing unified data control policies in a distributed and product-oriented computing platform that includes a plurality of distributed data service clusters and a centralized policy information repository. In some examples, the distributed data service cluster is associated with a distributed policy decision object and one or more distributed policy enforcement objects. In some examples, the distributed policy decision object generates control policy evaluation responses in response to control policy evaluation requests. Additional example embodiments provide, such as but not limited to, example methods for generating policy information objects.

Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: An example system for performing segmentation of data based on tensor inputs includes memory storing computer-executable instructions defining a learning network, where the learning network includes a plurality of sequential encoder down-sampling blocks. A processor is configured to execute the computer-executable instructions to receive a multi-dimensional input tensor including at least a first dimension, a second dimension and a plurality of channels. The processor is also configured to process the received multi-dimensional input tensor by passing the received multi-dimensional input tensor through the plurality of sequential encoder down-sampling blocks of the learning network, and to generate an output tensor in response to processing the received multi-dimensional input tensor. The output tensor includes at least one segmentation classification.

Abstract: Antibodies, and antigen-binding fragments thereof, that specifically bind to Cluster of Differentiation 1a (CD1a) are provided. Embodiments include uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.

Abstract: Systems and methods for account data association with voice interface devices are disclosed. For example, when a host user/primary user and guest user have consented for account data to be associated with the primary user's devices, a request to associate the account data may be received. Voice and device-based authentication may be performed to confirm the identity of the guest user and the guest user's account data may be associated with the primary user's devices. During a guest session, voice recognition may be utilized to determine if a given user utterance is from the guest user or the primary user, and actions may be performed by the voice interface device accordingly.

Abstract: In an approach for generating transaction tracking data that is used to simulate a customer environment or test case scenario, a processor receives user input data, wherein the user input data includes, at least, an application topology constructed using a graphical user interface. A processor validates the user input data for, at least, supported environments of components of the application topology. A processor generates transaction tracking data based on, at least, the user input data.

Abstract: In an approach for generating transaction tracking data that is used to simulate a customer environment or test case scenario, a processor receives user input data, wherein the user input data includes, at least, an application topology constructed using a graphical user interface. A processor validates the user input data for, at least, supported environments of components of the application topology. A processor generates transaction tracking data based on, at least, the user input data.

Abstract: A flexible container, system and method of manufacture can include an in-line system that allows flexible containers of varying sizes to be manufactured in a single relatively high speed and efficient production line and in a single clean room through the use of transport and exchange equipment configured to adeptly handle flexible containers throughout the process.

Abstract: In an approach for generating transaction tracking data that is used to simulate a customer environment or test case scenario, a processor receives user input data, wherein the user input data includes, at least, an application topology constructed using a graphical user interface. A processor validates the user input data for, at least, supported environments of components of the application topology. A processor generates transaction tracking data based on, at least, the user input data.

Abstract: In an approach for generating transaction tracking data that is used to simulate a customer environment or test case scenario, a processor receives user input data, wherein the user input data includes, at least, an application topology constructed using a graphical user interface. A processor validates the user input data for, at least, supported environments of components of the application topology. A processor generates transaction tracking data based on, at least, the user input data.

Abstract: In an approach for generating transaction tracking data that is used to simulate a customer environment or test case scenario, a processor receives user input data, wherein the user input data includes, at least, an application topology constructed using a graphical user interface. A processor validates the user input data for, at least, supported environments of components of the application topology. A processor generates transaction tracking data based on, at least, the user input data.

Abstract: In a method for generating test transactions across computing systems, a first test function of a first program on a first computing system of a plurality of computing systems receives a plurality of instructions, wherein a first instruction of the plurality of instructions is to invoke a first transaction between a second function of the first program and a second program on a second computing system of the plurality of computing systems. The first test function of the first program causes the transaction between the second function of the first program on the first computing system and the second program on the second computing system. The first test function of the first program sends the plurality of instructions to a second test function on a third computing system of the plurality of computing systems, based on a second instruction of the plurality of instructions.

Abstract: In a method for generating test transactions across computing systems, a first test function of a first program on a first computing system of a plurality of computing systems receives a plurality of instructions, wherein a first instruction of the plurality of instructions is to invoke a first transaction between a second function of the first program and a second program on a second computing system of the plurality of computing systems. The first test function of the first program causes the transaction between the second function of the first program on the first computing system and the second program on the second computing system. The first test function of the first program sends the plurality of instructions to a second test function on a third computing system of the plurality of computing systems, based on a second instruction of the plurality of instructions.

Abstract: In an approach for generating transaction tracking data that is used to simulate a customer environment or test case scenario, a processor receives user input data, wherein the user input data includes, at least, an application topology constructed using a graphical user interface. A processor validates the user input data for, at least, supported environments of components of the application topology. A processor generates transaction tracking data based on, at least, the user input data.

Abstract: In a method for generating test transactions across computing systems, a first test function of a first program on a first computing system of a plurality of computing systems receives a plurality of instructions, wherein a first instruction of the plurality of instructions is to invoke a first transaction between a second function of the first program and a second program on a second computing system of the plurality of computing systems. The first test function of the first program causes the transaction between the second function of the first program on the first computing system and the second program on the second computing system. The first test function of the first program sends the plurality of instructions to a second test function on a third computing system of the plurality of computing systems, based on a second instruction of the plurality of instructions.

Abstract: In a method for generating test transactions across computing systems, a first test function of a first program on a first computing system of a plurality of computing systems receives a plurality of instructions, wherein a first instruction of the plurality of instructions is to invoke a first transaction between a second function of the first program and a second program on a second computing system of the plurality of computing systems. The first test function of the first program causes the transaction between the second function of the first program on the first computing system and the second program on the second computing system. The first test function of the first program sends the plurality of instructions to a second test function on a third computing system of the plurality of computing systems, based on a second instruction of the plurality of instructions.

Abstract: A flexible container, system and method of manufacture can include an in-line system that allows flexible containers of varying sizes to be manufactured in a single relatively high speed and efficient production line and in a single clean room through the use of transport and exchange equipment configured to adeptly handle flexible containers throughout the process.

Abstract: This embodiment teaches a variation of GCD-based sieving, building tables of prime products, but intentionally restricting the size of table entries to fit within a single machine word. This combination allows one to mix advantages of the two most popular sieves, while retaining the simple and straightforward structure of the simpler one. Divisor length restriction can provide significant savings in the number of long divisions, but may be implemented with only two very specific primitives. The two primitives offer better optimization capabilities than a fully generic multiword arithmetic library.

Abstract: Linking sequence which modulate cross-talk between modules of Type I polyketide synthases have been identified. Thus, arbitrarily chosen modules can be mixed and matched by supplying the appropriate linkers to obtain desired polyketide synthases and new polyketides. The modules are provided suitable linkers so that the polyketide chain is passed from one module to the other in the correct sequence. Synthetic peptides which mimic linkers can be used to inhibit the synthesis of polyketides. Kinetic channeling, both intrapolypeptide and interpolypeptide, of diketide intermediates in a Type I polyketide synthase can occur. In addition, the role of protein-protein interactions between a donor acryl carrier protein (ACP) domain and a downstream ketosynthase (KS) domain and enzyme-substrate interactions in the channeling of intermediates between polyketide synthase modules and between a polyketide synthase module and a NRPS module has been identified.