Abstract: Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.

Abstract: Features relating to a vaporizer body are provided. The vaporizer body may include an outer shell that includes an inner region defined by an outer shell sidewall. A support structure is configured to fit within the inner region of the outer shell. The support structure includes a storage region defined by a top support structure, a bottom support structure, a bottom cap, and a gasket. An integrated board assembly is configured to fit within the storage region of the support structure. The integrated board assembly may include a printed circuit board assembly formed of multiple layers that form a rigid structure and that include an inner, flexible layer. A first antenna is integrated at a proximal end of the flexible layer, and a second antenna is integrated at a distal end of the flexible layer.

Abstract: Bands for wearable devices include multiple band retainers used to maintain engagement between an assembly (e.g., a pair) of bands. Some band retainers may be permanently affixed with the band at a certain location of the band, while other band retainers can be removable. The removable band retainers can be moved to different locations of the band, thus allowing the band retainer to retain another band at different locations. As a result, the assembly of bands can be used with different users, and in particular, users with different wrist sizes. Moreover, using multiple band retainers can provide an engagement force between the bands to withstand higher-impact events, such as swimming and diving. Additionally, bands and band retainers may include one or more liquid-resistant and corrosion-resistant materials.

Abstract: A computer system is configured to receiving a data set from a data provider and automatically save the data set in a quarantine database where copying, moving, and sharing of the data set are restricted until the data set is released by a data provider. The data set is parsed to find and mark portions with potentially sensitive information. At least those parts are reviewed by a data governor, who can confirm, add, edit, or remove markers. Those parts can be visually indicated to the data governor, along with a preview of, metadata about, and analysis of the data set. After reviewing at least the automatically marked portions, the data governor can release the data set to a non-quarantine database where another user can use the data set. The user is restricted from accessing the quarantine database.

Abstract: A work order prediction system is described. The work order prediction system analyzes retrieved sensor signal activity records to compare counts of signal activity in defined signal groupings to corresponding predetermined thresholds of sensor signal activity and generates a report based on the comparison when sensor signal activity exceeds the determined threshold values. The predetermined thresholds of sensor signal are determined for each signal grouping by comparing corresponding groupings of service record activity against determined counts of historical sensor signal activity to establish threshold values for each of the groupings and produce a model based on the comparison of the historical sensor signal activity to service activity.

Abstract: A work order prediction system is described. The work order prediction system analyzes retrieved sensor signal activity records to compare counts of signal activity in defined signal groupings to corresponding predetermined thresholds of sensor signal activity and generates a report based on the comparison when sensor signal activity exceeds the determined threshold values. The predetermined thresholds of sensor signal are determined for each signal grouping by comparing corresponding groupings of service record activity against determined counts of historical sensor signal activity to establish threshold values for each of the groupings and produce a model based on the comparison of the historical sensor signal activity to service activity.

Abstract: A hermetically sealed electronic closure device, or button, includes a self-renewing power source, a sensor for measuring a metric, a memory storing information, a data processing circuit for controlling operations of the device, and a transceiver for sending and receiving information. The device is a standard part of a clothing item that is inconspicuous to a wearer of the clothing item.

Abstract: Some implementations provide an interposer that includes a substrate, a via in the substrate, and an oxidation layer. The via includes a metal material. The oxidation layer is between the via and the substrate. In some implementations, the substrate is a silicon substrate. In some implementations, the oxidation layer is a thermal oxide formed by exposing the substrate to heat. In some implementations, the oxidation layer is configured to provide electrical insulation between the via and the substrate. In some implementations, the interposer also includes an insulation layer. In some implementations, the insulation layer is a polymer layer. In some implementations, the interposer also includes at least one interconnect on the surface of the interposer. The at least one interconnect is positioned on the surface of the interposer such that the oxidation layer is between the interconnect and the substrate.

Abstract: A probabilistic programming current is injected into a cluster of bi-stable probabilistic switching elements, the probabilistic programming current having parameters set to result in a less than unity probability of any given bi-stable switching element switching, and a resistance of the cluster of bi-stable switching elements is detected. The probabilistic programming current is injected and the resistance of the cluster state detected until a termination condition is met. Optionally the termination condition is detecting the resistance of the cluster of bi-stable switching elements at a value representing a multi-bit data.

Abstract: A probabilistic programming current is injected into a cluster of bi-stable probabilistic switching elements, the probabilistic programming current having parameters set to result in a less than unity probability of any given bi-stable switching element switching, and a resistance of the cluster of bi-stable switching elements is detected. The probabilistic programming current is injected and the resistance of the cluster state detected until a termination condition is met. Optionally the termination condition is detecting the resistance of the cluster of bi-stable switching elements at a value representing a multi-bit data.

Abstract: A hermetically sealed electronic closure device, or button, includes a self-renewing power source, a sensor for measuring a metric, a memory storing information, a data processing circuit for controlling operations of the device, and a transceiver for sending and receiving information. The device is a standard part of a clothing item that is inconspicuous to a wearer of the clothing item.

Abstract: A device wirelessly broadcasts branding information associated with a consumer product attached to the device. The branding information is sent to a receiver located remotely from the product.

Abstract: Wireless mobile communication device includes unified memory portion; processing units coupled with, and communicating through, unified memory; fault inhibitor coupled with unified memory inhibiting operational fault from nocent informon. Memory, fault inhibitor, and processing units fabricated on monolithic integrated circuit as system-on-chip disposed in wireless mobile personal host. Multiprocessor module includes fault inhibitor and applications and communications processing units and buses, coupled with unified memory. Integrated functional constituent can include coprocessor, accelerator, operational control unit, interprocessor controller, memory controller, bus management unit, bridge, arbiters, and transceiver. Method inhibits operational fault from nocent informon, setting device in operational or fallback state.