Patents by Inventor Nick Eattock

Nick Eattock has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods of preparing and analyzing cell-free nucleic acid sequencing libraries
    Patent number: 12024797
    Abstract: Aspects of the invention relate to methods for preparing and analyzing a sequencing library from a mixed cell-free DNA (cfDNA) sample, wherein the mixed sample includes double-stranded DNA (dsDNA), damaged dsDNA (e.g., nicked dsDNA), and single-stranded DNA (ssDNA) molecules. The subject methods facilitate the collection of information from dsDNA, ssDNA and damaged DNA (e.g., nicked DNA) molecules in a sample, thereby providing enhanced diagnostic information as compared to sequencing libraries that are prepared from dsDNA alone.
    Type: Grant
    Filed: December 23, 2020
    Date of Patent: July 2, 2024
    Assignee: GRAIL, LLC
    Inventors: Matthew H. Larson, Hyunsung John Kim, Nick Eattock, Xiao Yang
  • DIFFERENTIAL TAGGING OF RNA FOR PREPARATION OF A CELL-FREE DNA/RNA SEQUENCING LIBRARY
    Publication number: 20220010372
    Abstract: In various aspects, the present disclosure provides methods, compositions, reactions mixtures, kits, and systems for sequencing both RNA and DNA from a single source sample. In some embodiments, RNA is treated so as to differentiate RNA sequences from DNA sequences derived from the same sample. In some embodiments, the RNA and DNA are cell-free polynucleotides.
    Type: Application
    Filed: September 24, 2021
    Publication date: January 13, 2022
    Inventors: Matthew Larson, H. John Kim, Nick Eattock, Arash Jamshidi
  • Differential tagging of RNA for preparation of a cell-free DNA/RNA sequencing library
    Patent number: 11180801
    Abstract: In various aspects, the present disclosure provides methods, compositions, reactions mixtures, kits, and systems for sequencing both RNA and DNA from a single source sample. In some embodiments, RNA is treated so as to differentiate RNA sequences from DNA sequences derived from the same sample. In some embodiments, the RNA and DNA are cell-free polynucleotides.
    Type: Grant
    Filed: October 31, 2018
    Date of Patent: November 23, 2021
    Assignee: GRAIL, LLC
    Inventors: Matthew Larson, H. John Kim, Nick Eattock, Arash Jamshidi
  • METHODS OF PREPARING AND ANALYZING CELL-FREE NUCLEIC ACID SEQUENCING LIBRARIES
    Publication number: 20210115512
    Abstract: Aspects of the invention relate to methods for preparing and analyzing a sequencing library from a mixed cell-free DNA (cfDNA) sample, wherein the mixed sample includes double-stranded DNA (dsDNA), damaged dsDNA (e.g., nicked dsDNA), and single-stranded DNA (ssDNA) molecules. The subject methods facilitate the collection of information from dsDNA, ssDNA and damaged DNA (e.g., nicked DNA) molecules in a sample, thereby providing enhanced diagnostic information as compared to sequencing libraries that are prepared from dsDNA alone.
    Type: Application
    Filed: December 23, 2020
    Publication date: April 22, 2021
    Inventors: Matthew H. Larson, Hyunsung John Kim, Nick Eattock, Xiao Yang
  • Methods of preparing and analyzing cell-free nucleic acid sequencing libraries
    Patent number: 10907206
    Abstract: Aspects of the invention relate to methods for preparing and analyzing a sequencing library from a mixed cell-free DNA (cfDNA) sample, wherein the mixed sample includes double-stranded DNA (dsDNA), damaged dsDNA (e.g., nicked dsDNA), and single-stranded DNA (ssDNA) molecules. The subject methods facilitate the collection of information from dsDNA, ssDNA and damaged DNA (e.g., nicked DNA) molecules in a sample, thereby providing enhanced diagnostic information as compared to sequencing libraries that are prepared from dsDNA alone.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: February 2, 2021
    Assignee: GRAIL, Inc.
    Inventors: Matthew H. Larson, Hyunsung John Kim, Nick Eattock, Xiao Yang
  • METHODS OF PREPARING AND ANALYZING CELL-FREE NUCLEIC ACID SEQUENCING LIBRARIES
    Publication number: 20200056233
    Abstract: Aspects of the invention relate to methods for preparing and analyzing a sequencing library from a mixed cell-free DNA (cfDNA) sample, wherein the mixed sample includes double-stranded DNA (dsDNA), damaged dsDNA (e.g., nicked dsDNA), and single-stranded DNA (ssDNA) molecules. The subject methods facilitate the collection of information from dsDNA, ssDNA and damaged DNA (e.g., nicked DNA) molecules in a sample, thereby providing enhanced diagnostic information as compared to sequencing libraries that are prepared from dsDNA alone.
    Type: Application
    Filed: October 24, 2019
    Publication date: February 20, 2020
    Inventors: Matthew H. Larson, Hyunsung John Kim, Nick Eattock, Xiao Yang
  • Methods of preparing and analyzing cell-free nucleic acid sequencing libraries
    Patent number: 10487358
    Abstract: Aspects of the invention relate to methods for preparing and analyzing a sequencing library from a mixed cell-free DNA (cfDNA) sample, wherein the mixed sample includes double-stranded DNA (dsDNA), damaged dsDNA (e.g., nicked dsDNA), and single-stranded DNA (ssDNA) molecules. The subject methods facilitate the collection of information from dsDNA, ssDNA and damaged DNA (e.g., nicked DNA) molecules in a sample, thereby providing enhanced diagnostic information as compared to sequencing libraries that are prepared from dsDNA alone.
    Type: Grant
    Filed: September 22, 2017
    Date of Patent: November 26, 2019
    Assignee: GRAIL, Inc.
    Inventors: Matthew H. Larson, Hyunsung John Kim, Nick Eattock, Xiao Yang
  • DIFFERENTIAL TAGGING OF RNA FOR PREPARATION OF A CELL-FREE DNA/RNA SEQUENCING LIBRARY
    Publication number: 20190062831
    Abstract: In various aspects, the present disclosure provides methods, compositions, reactions mixtures, kits, and systems for sequencing both RNA and DNA from a single source sample. In some embodiments, RNA is treated so as to differentiate RNA sequences from DNA sequences derived from the same sample. In some embodiments, the RNA and DNA are cell-free polynucleotides.
    Type: Application
    Filed: October 31, 2018
    Publication date: February 28, 2019
    Inventors: Matthew Larson, H. John Kim, Nick Eattock, Arash Jamshidi
  • Differential tagging of RNA for preparation of a cell-free DNA/RNA sequencing library
    Patent number: 10144962
    Abstract: In various aspects, the present disclosure provides methods, compositions, reactions mixtures, kits, and systems for sequencing both RNA and DNA from a single source sample. In some embodiments, RNA is treated so as to differentiate RNA sequences from DNA sequences derived from the same sample. In some embodiments, the RNA and DNA are cell-free polynucleotides.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: December 4, 2018
    Assignee: GRAIL, Inc.
    Inventors: Matthew Larson, H. John Kim, Nick Eattock, Arash Jamshidi
  • METHODS OF PREPARING AND ANALYZING CELL-FREE NUCLEIC ACID SEQUENCING LIBRARIES
    Publication number: 20180087105
    Abstract: Aspects of the invention relate to methods for preparing and analyzing a sequencing library from a mixed cell-free DNA (cfDNA) sample, wherein the mixed sample includes double-stranded DNA (dsDNA), damaged dsDNA (e.g., nicked dsDNA), and single-stranded DNA (ssDNA) molecules. The subject methods facilitate the collection of information from dsDNA, ssDNA and damaged DNA (e.g., nicked DNA) molecules in a sample, thereby providing enhanced diagnostic information as compared to sequencing libraries that are prepared from dsDNA alone.
    Type: Application
    Filed: September 22, 2017
    Publication date: March 29, 2018
    Inventors: Matthew H. Larson, Hyunsung John Kim, Nick Eattock, Xiao Yang
  • DIFFERENTIAL TAGGING OF RNA FOR PREPARATION OF A CELL-FREE DNA/RNA SEQUENCING LIBRARY
    Publication number: 20180002749
    Abstract: In various aspects, the present disclosure provides methods, compositions, reactions mixtures, kits, and systems for sequencing both RNA and DNA from a single source sample. In some embodiments, RNA is treated so as to differentiate RNA sequences from DNA sequences derived from the same sample. In some embodiments, the RNA and DNA are cell-free polynucleotides.
    Type: Application
    Filed: June 29, 2017
    Publication date: January 4, 2018
    Inventors: Matthew Larson, H. John Kim, Nick Eattock, Arash Jamshidi