Patents by Inventor Nick Knudsen

Nick Knudsen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified Leptin Polypeptides and Their Uses
    Publication number: 20120149636
    Abstract: Modified human leptin polypeptides and uses thereof are provided.
    Type: Application
    Filed: February 5, 2009
    Publication date: June 14, 2012
    Applicant: AMBRX, INC.
    Inventors: Vadim Kraynov, Anna-Maria A. Hays Putnam, Nick Knudsen, Jason Pinkstaff, Heather Myler, Lorraine Sullivan
  • Methods for expression and purification of recombinant human growth hormone
    Patent number: 8178108
    Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encoded amino acids and hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: May 15, 2012
    Assignee: Ambrx, Inc.
    Inventors: Ying Buechler, Ricky Lieu, Michael Ong, Stuart Bussell, Nick Knudsen, Ho Sung Cho
  • MODIFIED RELAXIN POLYPEPTIDES AND THEIR USES
    Publication number: 20120046229
    Abstract: Modified relaxin polypeptides and their uses thereof are provided
    Type: Application
    Filed: August 17, 2011
    Publication date: February 23, 2012
    Applicant: AMBRX, INC.
    Inventors: Vadim KRAYNOV, Nick KNUDSEN, Amha HEWET, Kristine DE DIOS, Jason PINKSTAFF, Lorraine SULLIVAN
  • Modified interferon beta polypeptides and their uses
    Patent number: 8114630
    Abstract: Modified interferon beta polypeptides and uses thereof are provided.
    Type: Grant
    Filed: April 30, 2008
    Date of Patent: February 14, 2012
    Assignee: Ambrx, Inc.
    Inventors: Vadim Kraynov, Nick Knudsen, Anna-Maria A. Hays Putnam, Denise Krawitz, Jason Pinkstaff, Heather Myler
  • Pegylated human interferon polypeptides
    Patent number: 8093356
    Abstract: Modified human interferon polypeptides and uses thereof are provided, including PEGylated human interferon polypeptides with one or more non-naturally encoded amino acids.
    Type: Grant
    Filed: October 26, 2007
    Date of Patent: January 10, 2012
    Assignee: Ambrx, Inc.
    Inventors: Anna-Maria A. Hays, Bruce E. Kimmel, Ho Sung Cho, Bee-Cheng Sim, David C. Litzinger, Roberto Mariani, Vadim Kraynov, Nick Knudsen, Thomas O. Daniel, Alan Koder, Stuart Bussell, Junjie Liu, Zhenwei Miao, Theresa Morrow
  • Process of producing non-naturally encoded amino acid containing high conjugated to a water soluble polymer
    Patent number: 8080391
    Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
    Type: Grant
    Filed: December 21, 2005
    Date of Patent: December 20, 2011
    Assignee: AMBRX, Inc.
    Inventors: Ying Buechler, Ricky Lieu, Michael Ong, Stuart Bussell, Nick Knudsen, Ho Sung Cho
  • Modified FGF-21 polypeptides and their uses
    Patent number: 8012931
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Grant
    Filed: March 19, 2008
    Date of Patent: September 6, 2011
    Assignee: Ambrx, Inc.
    Inventors: Thomas P. Cujec, Roberto Mariani, Anna-Maria A. Hays Putnam, William M. Keefe, Nick Knudsen, Lillian Ho, Jason Pinkstaff, Vadim Kraynov
  • Modified Human Apolipoprotein A-1 and Their Uses
    Publication number: 20110178029
    Abstract: Modified human apolipoprotein A-I polypeptides and uses thereof are provided.
    Type: Application
    Filed: September 15, 2008
    Publication date: July 21, 2011
    Applicant: AMBRX, INC.
    Inventors: Nick Knudsen, Stuart Bussell, Vadim Kraynov
  • Modified FGF-21 Polypeptides and Their Uses
    Publication number: 20110172401
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Application
    Filed: March 18, 2011
    Publication date: July 14, 2011
    Applicant: AMBRX, INC.
    Inventors: Thomas P. CUJEC, Roberto MARIANI, Anna-Maria A. HAYS PUTNAM, William M. KEEFE, Nick KNUDSEN, Lillian Ho, Jason PINKSTAFF, Vadim KRAYNOV
  • Methods for expression and purification of recombinant human growth hormone mutants
    Patent number: 7959926
    Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encoded amino acids and hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
    Type: Grant
    Filed: October 17, 2007
    Date of Patent: June 14, 2011
    Assignee: Ambrx, Inc.
    Inventors: Ying Buechler, Ricky Lieu, Michael Ong, Stuart Bussell, Nick Knudsen, Ho Sung Cho
  • Methods for expression and purification of pegylated recombinant human growth hormone containing a non-naturally encoded keto amino acid
    Patent number: 7947473
    Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH comprising non-naturally encoded amino acids and hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
    Type: Grant
    Filed: January 31, 2008
    Date of Patent: May 24, 2011
    Assignee: AMBRX, Inc.
    Inventors: Ying Buechler, Ricky Lieu, Michael Ong, Stuart Bussell, Nick Knudsen, Ho Sung Cho
  • Human Interferon Molecules and Their Uses
    Publication number: 20100135959
    Abstract: Modified human interferon polypeptides and uses thereof are provided.
    Type: Application
    Filed: June 2, 2006
    Publication date: June 3, 2010
    Applicant: AMBRX, INC.
    Inventors: Anna-Maria A. Hays Putnam, Bruce E. Kimmel, Ho Sung Cho, Bee-Cheng Sim, David C. Litzinger, Roberto Mariani, Vadim Kraynov, Nick Knudsen, Thomas O. Daniel, Alan Koder, Stuart Bussell, Junjie Liu, Zhenwei Miao, Theresa Morrow
  • Modified Bovine G-CSF Polypeptides And Their Uses
    Publication number: 20100035812
    Abstract: Modified bovine G-CSF polypeptides and uses thereof are provided.
    Type: Application
    Filed: July 22, 2009
    Publication date: February 11, 2010
    Applicants: AMBRX, INC., ELI LILLY AND COMPANY
    Inventors: Anna-Maria A. HAYS PUTNAM, Nick KNUDSEN, Thea NORMAN, Alan KODER, Vadim KRAYNOV, Lillian HO, Peter C. CANNING
  • MODIFIED INTERFERON BETA POLYPEPTIDES AND THEIR USES
    Publication number: 20090208454
    Abstract: Modified interferon beta polypeptides and uses thereof are provided.
    Type: Application
    Filed: April 30, 2008
    Publication date: August 20, 2009
    Applicant: AMBRX, INC.
    Inventors: Vadim KRAYNOV, Nick KNUDSEN, Anna-Maria A. HAYS PUTNAM, Denise KRAWITZ, Jason PINKSTAFF, Heather MYLER
  • Modified FGF-21 Polypeptides and Their Uses
    Publication number: 20080255045
    Abstract: Modified FGF-21 polypeptides and uses thereof are provided.
    Type: Application
    Filed: March 19, 2008
    Publication date: October 16, 2008
    Applicant: AMBRX, INC.
    Inventors: Thomas P. CUJEC, Roberto MARIANI, Anna-Maria A. HAYS PUTNAM, William M. KEEFE, Nick KNUDSEN, Lillian HO, Jason PINKSTAFF, Vadim KRAYNOV
  • Methods for Expression and Purification of Recombinant Human Growth Hormone
    Publication number: 20080199909
    Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
    Type: Application
    Filed: January 31, 2008
    Publication date: August 21, 2008
    Applicant: AMBRX, INC.
    Inventors: Ying BUECHLER, Ricky LIEU, Michael ONG, Stuart BUSSELL, Nick KNUDSEN, Ho Sung CHO
  • Human Interferon Molecules and Their Uses
    Publication number: 20080132681
    Abstract: Modified human interferon polypeptides and uses thereof are provided.
    Type: Application
    Filed: October 26, 2007
    Publication date: June 5, 2008
    Applicant: AMBRX, INC.
    Inventors: Anna-Maria A. HAYS, Bruce E. KIMMEL, Ho Sung CHO, Bee-Cheng SIM, David C. LITZINGER, Roberto MARIANI, Vadim KRAYNOV, Nick Knudsen, Thomas O. DANIEL, Alan KODER, Stuart BUSSELL, Junjie LIU, Zhenwei MIAO, Theresa MORROW
  • Human Interferon Molecules and Their Uses
    Publication number: 20080119640
    Abstract: Modified human interferon polypeptides and uses thereof are provided.
    Type: Application
    Filed: October 26, 2007
    Publication date: May 22, 2008
    Applicant: AMBRX, INC.
    Inventors: Anna-Maria A. HAYS, Bruce E. KIMMEL, Ho Sung CHO, Bee-Cheng SIM, David C. LITZINGER, Roberto MARIANI, Vadim KRAYNOV, Nick Knudsen, Thomas O. DANIEL, Alan KODER, Stuart BUSSELL, Junjie LIU, Zhenwei MIAO, Theresa MORROW
  • Human Interferon Molecules and Their Uses
    Publication number: 20080108792
    Abstract: Modified human interferon polypeptides and uses thereof are provided.
    Type: Application
    Filed: October 26, 2007
    Publication date: May 8, 2008
    Applicant: AMBRX, INC.
    Inventors: Anna-Maria Hays, Bruce Kimmel, Ho Sung Cho, Bee-Cheng SIM, David Litzinger, Roberto Mariani, Vadim Kraynov, Nick Knudsen, Thomas Daniel, Alan Koder, Stuart Bussell, Junjie Liu, Zhenwei Miao, Theresa Morrow
  • Methods for Expression and Purification of Recombinant Human Growth Hormone
    Publication number: 20080085538
    Abstract: The present invention relates generally to the production, purification, and isolation of human growth hormone (hGH). More particularly, the invention relates to the production, purification, and isolation of substantially purified hGH from recombinant host cells or culture medium including, for example, yeast, insect, mammalian and bacterial host cells. The process of the present invention is also useful for purification of hGH linked to polymers or other molecules.
    Type: Application
    Filed: October 17, 2007
    Publication date: April 10, 2008
    Applicant: AMBRX, INC.
    Inventors: Ying BUECHLER, Ricky LIEU, Michael ONG, Stuart BUSSELL, Nick KNUDSEN, Ho Sung CHO