Patents by Inventor Nick Loizos

Nick Loizos has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • CELLULAR COMPOSITIONS COMPRISING VIRAL VECTORS AND METHODS OF TREATMENT
    Publication number: 20220275337
    Abstract: The present disclosure relates to cellular compositions that are modified to introduce a recombinant virus. Such compositions may be used to treat cancer by delivering vims to cancer cells.
    Type: Application
    Filed: August 5, 2020
    Publication date: September 1, 2022
    Inventors: Dan DEVINE, Nick LOIZOS, Silviu ITESCU
  • CELLULAR COMPOSITIONS AND METHODS OF TREATMENT I
    Publication number: 20210163932
    Abstract: The present disclosure relates to cellular compositions that are modified to introduce a nucleic acid or vector expressing the same. Such compositions may be used to deliver nucleic acid to a target cell and treat disease such as cancer.
    Type: Application
    Filed: November 21, 2018
    Publication date: June 3, 2021
    Applicant: Mesoblast International Sárl
    Inventors: Peter BRINK, Ira COHEN, Richard LIN, Sergey DORONIN, Irina POTAPOVA, Virginijus VALIUNAS, Dan DEVINE, Anthony SANDRASAGRA, Nick LOIZOS, Silviu ITESCU
  • COMBINATION THERAPY
    Publication number: 20170129958
    Abstract: Combination of human antibodies that bind to human platelet-derived growth factor receptor alpha (PDGFR alpha), preferably olaratumab, and doxorubicin as a medicament for the treatment of soft tissue sarcoma.
    Type: Application
    Filed: June 26, 2015
    Publication date: May 11, 2017
    Applicant: ImClone LLC
    Inventors: Nick LOIZOS, Gaurav D. SHAH
  • Antibodies against PDGFR? to inhibit tumor growth
    Patent number: 8574578
    Abstract: The invention provides antibodies that bind to human PDGFR? and neutralize activation of the receptor. The invention further provides methods for neutralizing activation of PDGFR? and methods of treating a mammal with a neoplastic disease using the antibodies alone or in combination with other agents.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: November 5, 2013
    Assignee: ImClone LLC
    Inventors: Nick Loizos, Jim Huber
  • Methods of treating secondary bone tumors with antibodies against PDGFR alpha
    Patent number: 8425911
    Abstract: The invention provides methods of treating bone cancer, particularly metastatic bone cancer, by administering a PDGFR alpha antagonist. The invention further provides methods of treating a mammal with a neoplastic disease using the antibodies alone or in combination with other agents.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: April 23, 2013
    Assignees: ImClone LLC, Philadelphia Health and Education Corporation
    Inventors: Nick Loizos, Alessandro Fatatis, Nathan Graeme Dolloff
  • Antibodies against PDGFRa
    Patent number: 8128929
    Abstract: The invention provides antibodies that bind to human PDGFR? and neutralize activation of the receptor. The invention further provides methods for neutralizing activation of PDGFR? and methods of treating a mammal with a neoplastic disease using the antibodies alone or in combination with other agents.
    Type: Grant
    Filed: June 19, 2006
    Date of Patent: March 6, 2012
    Assignee: ImClone LLC
    Inventors: Nick Loizos, Jim Huber
  • METHODS OF TREATING SECONDARY BONE TUMORS WITH ANTIBODIES AGAINST PDGFR ALPHA
    Publication number: 20120034244
    Abstract: The invention provides methods of treating bone cancer, particularly metastatic bone cancer, by administering an IGF-IR antagonist and/or a PDGFR? antagonist. The invention also provides antibodies that bind to human PDGFR? and neutralize activation of the receptor. The invention further provides a methods for neutralizing activation of PDGFR?, and a methods of treating a mammal with a neoplastic disease using the antibodie alone or in combination with other agents.
    Type: Application
    Filed: October 19, 2011
    Publication date: February 9, 2012
    Applicants: PHILADELPHIA HEALTH AND EDUCATION CORPORATION D/B/A DREXEL UNIVERSITY COLLEGE, IMCLONE LLC
    Inventors: Nick LOIZOS, Alessandro FATATIS, Nathan Graeme DOLLOFF
  • ANTIBODIES AGAINST PDGFR ALPHA TO INHIBIT TUMOR GROWTH
    Publication number: 20120027767
    Abstract: The invention provides antibodies that bind to human PDGFR? and neutralize activation of the receptor. The invention further provides methods for neutralizing activation of PDGFR? and a methods of treating a mammal with a neoplastic disease using the antibodies alone or in combination with other agents.
    Type: Application
    Filed: October 19, 2011
    Publication date: February 2, 2012
    Applicant: IMCLONE LLC
    Inventors: Nick LOIZOS, Jim HUBER