Abstract: Disclosed are methods and compositions relating to antisense therapy for treating epilepsy, such as a focal epilepsy and temporal lobe epilepsy, in a subject in need thereof by targeting GRIK2 mRNA. In particular, the disclosure provides methods for treating symptoms (e.g., seizures) of epilepsy in a subject by administering a particular dose in a defined volume and in a specific route of administration of an inhibitory ribopolynucleotide or adeno-associated viral vector encoding the same, which is capable of inhibiting expression of GRIK2.

Abstract: Disclosed are methods and compositions relating to antisense therapy for treating epilepsy, such as a focal epilepsy and temporal lobe epilepsy, in a subject in need thereof by targeting GRIK2 mRNA. In particular, the disclosure provides methods for treating symptoms (e.g., seizures) of epilepsy in a subject by administering a particular dose in a defined volume and in a specific route of administration of an inhibitory ribopolynucleotide or adeno-associated viral vector encoding the same, which is capable of inhibiting expression of GRIK2.

Abstract: Aspects of the disclosure relate to multicomputer processing of an event request from an event origination device with centralized event orchestration. A computing platform may receive, from an event origination device, an event request for an event. Subsequently, the computing platform may determine a sub-event associated with the event. Next, the computing platform may receive, from an event dataset customization engine, an event customized dataset generated for the sub-event. Then, the computing platform may generate, based on the sub-event associated with the event received from the event origination device, one or more event orchestration commands directing a sub-event processing device to execute the sub-event. Thereafter, the computing platform may receive, from the sub-event processing device, a results dataset. Subsequently, the computing platform may update, based on the results dataset, a master event dataset associated with the event.

Abstract: Aspects of the disclosure relate to multicomputer processing of an event request from an event origination device with centralized event orchestration. A computing platform may receive, from an event origination device, an event request for an event. Subsequently, the computing platform may determine a sub-event associated with the event. Next, the computing platform may receive, from an event dataset customization engine, an event customized dataset generated for the sub-event. Then, the computing platform may generate, based on the sub-event associated with the event received from the event origination device, one or more event orchestration commands directing a sub-event processing device to execute the sub-event. Thereafter, the computing platform may receive, from the sub-event processing device, a results dataset. Subsequently, the computing platform may update, based on the results dataset, a master event dataset associated with the event.