Patents by Inventor Nick Roelofs

Nick Roelofs has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA polymerase compositions for quantitative PCR and methods thereof
    Patent number: 8283148
    Abstract: The invention relates to the generation and characterization of Archaeal DNA polymerase mutants with deficient 3?-5? exonuclease activity and reduced base analog detection activity. The invention further provides for Archaeal DNA polymerase mutants with deficient 3?-5? exonuclease activity and reduced base analog detection activity containing additional mutations that modulate other DNA polymerase activities including DNA polymerization or reverse transcriptase activity. The invention also discloses methods and applications of DNA polymerases with deficient 3?-5? exonuclease activity and reduced base analog detection activity.
    Type: Grant
    Filed: December 12, 2003
    Date of Patent: October 9, 2012
    Assignee: Agilent Technologies, Inc.
    Inventors: Joseph A. Sorge, Reinhold Dietrich Mueller, Gothami Padmabandu, Nick Roelofs, Holly H. Hogrefe
  • DNA polymerase compositions for quantitative PCR and methods thereof
    Publication number: 20050069908
    Abstract: The invention relates to the generation and characterization of Archaeal DNA polymerase mutants with deficient 3?-5? exonuclease activity and reduced base analog detection activity. The invention further provides for Archaeal DNA polymerase mutants with deficient 3?-5? exonuclease activity and reduced base analog detection activity containing additional mutations that modulate other DNA polymerase activities including DNA polymerization or reverse transcriptase activity. The invention also discloses methods and applications of DNA polymerases with deficient 3?-5? exonuclease activity and reduced base analog detection activity.
    Type: Application
    Filed: December 12, 2003
    Publication date: March 31, 2005
    Inventors: Joseph Sorge, Reinhold Mueller, Gothami Padmabandu, Nick Roelofs, Holly Hogrefe