Patents by Inventor Niclas ROXHED

Niclas ROXHED has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11504959
    Abstract: A method for transferring an atomically thin layer comprising providing a target substrate and a donor substrate on which a first atomically thin layer has been formed. The method further comprises disposing an adhesion layer at the donor substrate or at the target substrate. The method further comprises bringing the target substrate and the donor substrate together. Further, the method comprises bonding together the donor substrate, the adhesion layer and the target substrate and removing the donor substrate.
    Type: Grant
    Filed: January 24, 2020
    Date of Patent: November 22, 2022
    Inventors: Arne Quellmalz, Kristinn Gylfason, Niclas Roxhed, Göran Stemme, Frank Niklaus
  • Patent number: 11484882
    Abstract: The microfluidic device has a first reservoir that preferably includes a first liquid. The first liquid is being held by a capillary stop valve in the first reservoir. A second reservoir is in fluid communication with the first reservoir. The second reservoir has a second liquid and a sample support disposed therein. The second reservoir has an inlet opening defined therein. A draining unit is adjacent to the second reservoir. The draining unit is in fluid communication with the second reservoir. The draining unit has a first absorption member disposed therein.
    Type: Grant
    Filed: September 17, 2020
    Date of Patent: November 1, 2022
    Assignee: Intelligent Virus Imaging Inc.
    Inventors: Janosch Hauser, Gustaf Kylberg, Göran Stemme, Ida-Maria Sintorn, Niclas Roxhed
  • Patent number: 11485945
    Abstract: The method is for preparing a sample in a microfluidic device. A microfluidic device is provided that has a first reservoir in fluid communication with a second reservoir in fluid communication with and adjacent to a draining unit that has a first absorbing member disposed therein. The first reservoir contains a first liquid that is held in the first reservoir by a capillary stop valve connecting the first and second reservoirs. The second reservoir has a sample support disposed therein. A second liquid, containing substances, is added to the second reservoir. The second liquid contacts the first liquid and the first absorbing member. The first absorbing member absorbs the second liquid and the first liquid. The substances adhere to the sample support.
    Type: Grant
    Filed: September 18, 2020
    Date of Patent: November 1, 2022
    Assignee: Intelligent Virus Imaging Inc
    Inventors: Janosch Hauser, Gustaf Kylberg, Göran Stemme, Ida-Maria Sintorn, Niclas Roxhed
  • Publication number: 20220324703
    Abstract: Method and arrangement for assembling one or more microchips (415; 615; 715; 815; 915; 1015) into one or more holes (422; 722), respectively, in a substrate surface (421; 721) of a separate receiving substrate (420; 720; 820; 1020). The holes (422; 722) of the substrate is for microchip insertion out-of-plane in relation to said substrate surface. Each of said microchips is provided with a ferromagnetic layer (213; 613) of ferromagnetic material. The microchips are placed (503) on said substrate surface (421; 721) and it is applied and moved (504) one or more magnetic fields affecting said ferromagnetic layer (213; 613) of each microchip such that the microchips thereby become out-of-plane oriented in relation to said substrate surface (421; 721) and move over the substrate surface (421; 721) until assembled into said holes (422; 722).
    Type: Application
    Filed: September 10, 2020
    Publication date: October 13, 2022
    Inventors: Federico RIBET, Miku BRODIN-LAAKSO, Simone PAGLIANO, Frank NIKLAUS, Niclas ROXHED, Göran STEMME
  • Publication number: 20220280435
    Abstract: Components with relatively high loading of active pharmaceutical ingredients (e.g., drugs), are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent (e.g., a solid API) and a supporting material (e.g., a binder such as a polymer) such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt % versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, GI mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle.
    Type: Application
    Filed: March 15, 2022
    Publication date: September 8, 2022
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital Inc.
    Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, Robert S. Langer
  • Publication number: 20220257855
    Abstract: Self-actuating articles including, for example, self-actuating needles and/or self-actuating biopsy punches, are generally provided. Advantageously, the self-actuating articles described herein may be useful as a general platform for delivery of a wide variety of pharmaceutical drugs that are typically delivered via injection directly into tissue due to degradation in the GI tract. The self-actuating articles described herein may also be used to deliver sensors and/or take biopsies without the need for an endoscopy. In some embodiments, the article comprises a spring (e.g., a coil spring, a beam, a material having particular mechanical recovery characteristics).
    Type: Application
    Filed: May 17, 2018
    Publication date: August 18, 2022
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, Robert S. Langer
  • Patent number: 11369574
    Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject).
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: June 28, 2022
    Assignees: Massachusetts Institute of Technology, Novo Nordisk A/S, The Brigham and Women's Hospital, Inc.
    Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, Robert S. Langer, Jorrit Jeroen Water, Morten Revsgaard Frederiksen, Bo Uldall Kristiansen, Mikkel Oliver Jespersen, Mette Poulsen, Peter Herskind, Brian Jensen
  • Publication number: 20220175681
    Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject).
    Type: Application
    Filed: October 8, 2021
    Publication date: June 9, 2022
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital Inc.
    Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, Robert S. Langer
  • Publication number: 20220161537
    Abstract: A method for transferring an atomically thin layer comprising providing a target substrate and a donor substrate on which a first atomically thin layer has been formed. The method further comprises disposing an adhesion layer at the donor substrate or at the target substrate. The method further comprises bringing the target substrate and the donor substrate together. Further, the method comprises bonding together the donor substrate, the adhesion layer and the target substrate and removing the donor substrate.
    Type: Application
    Filed: January 24, 2020
    Publication date: May 26, 2022
    Inventors: Ame QUELLMALZ, Niclas ROXHED, Kristinn GYLFASON, Göran STEMME, Frank NIKLAUS
  • Publication number: 20220151940
    Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject).
    Type: Application
    Filed: November 19, 2021
    Publication date: May 19, 2022
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, David Dellal, Robert S. Langer
  • Patent number: 11311489
    Abstract: Components with relatively high loading of active pharmaceutical ingredients are generally provided. In some embodiments, the component (e.g., a tissue interfacing component) comprises a solid therapeutic agent and a supporting material such that the solid therapeutic agent is present in the component in an amount of greater than or equal to 10 wt % versus the total weight of the tissue interfacing component. Such tissue-interfacing components may be useful for delivery of API doses e.g., to a subject. Advantageously, in some embodiments, the reduction of volume required to deliver the required API dose as compared to a liquid formulation permits the creation of solid needle delivery systems for a wide variety of drugs in a variety of places/tissues (e.g., tongue, GI mucosal tissue, skin) and/or reduces and/or eliminates the application of an external force in order to inject a drug solution through the small opening in the needle.
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: April 26, 2022
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, Robert S. Langer
  • Publication number: 20220080419
    Abstract: The microfluidic device has a first reservoir that preferably includes a first liquid. The first liquid is being held by a capillary stop valve in the first reservoir. A second reservoir is in fluid communication with the first reservoir. The second reservoir has a second liquid and a sample support disposed therein. The second reservoir has an inlet opening defined therein. A draining unit is adjacent to the second reservoir. The draining unit is in fluid communication with the second reservoir. The draining unit has a first absorption member disposed therein.
    Type: Application
    Filed: September 17, 2020
    Publication date: March 17, 2022
    Inventors: Janosch Hauser, Gustaf Kylberg, Göran Stemme, Ida-Maria Sintorn, Niclas Roxhed
  • Publication number: 20220080115
    Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject).
    Type: Application
    Filed: May 17, 2018
    Publication date: March 17, 2022
    Applicants: Massachusetts Institute of Technology, The Brigham and Woman's Hospital, Inc.
    Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, Robert S. Langer
  • Publication number: 20220081662
    Abstract: The method is for preparing a sample in a microfluidic device. A microfluidic device is provided that has a first reservoir in fluid communication with a second reservoir in fluid communication with and adjacent to a draining unit that has a first absorbing member disposed therein. The first reservoir contains a first liquid that is held in the first reservoir by a capillary stop valve connecting the first and second reservoirs. The second reservoir has a sample support disposed therein. A second liquid, containing substances, is added to the second reservoir. The second liquid contacts the first liquid and the first absorbing member. The first absorbing member absorbs the second liquid and the first liquid. The substances adhere to the sample support.
    Type: Application
    Filed: September 18, 2020
    Publication date: March 17, 2022
    Inventors: Janosch Hauser, Gustaf Kylberg, Göran Stemme, Ida-Maria Sintorn, Niclas Roxhed
  • Publication number: 20220072241
    Abstract: A spray nozzle chip comprising: a first layer provided with a first layer orifice, and a mechanically flexible nozzle layer provided with a nozzle orifice, wherein the first layer has a valve seat arranged aligned with the nozzle orifice, wherein the spray nozzle chip has a valve functionality obtained by movement of the nozzle layer relative to the valve seat due to pressure changes, and wherein the nozzle layer is arranged at a distance from the valve seat when the nozzle layer is in a default non-pressurised state, whereby a gap with a gap length (L) is formed between the nozzle layer and the valve seat, wherein the gap length (L) is smaller than a dimension of a specific bacterial type, to thereby seal against bacterial ingrowth through the nozzle orifice of the specific bacterial type.
    Type: Application
    Filed: December 27, 2019
    Publication date: March 10, 2022
    Inventors: Niclas Roxhed, Torben Last, Göran Stemme
  • Publication number: 20220039686
    Abstract: A drug delivery device for administration to a subject is provided. In some embodiments, the drug delivery device includes a reservoir containing an active pharmaceutical ingredient and a potential energy source. The drug delivery device also includes a trigger operatively associated with the potential energy source, where the trigger is configured to actuate at a predetermined location within the subject. The drug delivery device also includes a rupturable membrane disposed along a flow path extending between the reservoir and an outlet, where the membrane is configured to rupture when the trigger is actuated. Once the trigger is actuated, the potential energy from the potential energy source may be released to expel the active pharmaceutical ingredient in a jet through the outlet.
    Type: Application
    Filed: August 9, 2021
    Publication date: February 10, 2022
    Applicants: Massachusetts Institute of Technology, NOVO NORDISK A/S, The Brigham and Women's Hospital, Inc.
    Inventors: Graham Arrick, Torben Sebastian Last, Declan Gwynne, Jacob Wainer, Carlo Giovanni Traverso, Drago Sticker, Cody Cleveland, Aghiad Ghazal, Adam Bohr, Jorrit Jeroen Water, Brian Mouridsen, Jacob Pyung Hwa Jepsen, Bozhidar Nikolaev Kozhuharov, Kim Frandsen, Robert Langer, Yi Lu, Niclas Roxhed, Siheng You
  • Patent number: 11207272
    Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject).
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: December 28, 2021
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, David Dellal, Robert S. Langer
  • Publication number: 20210361919
    Abstract: Articles for rapid release of components including, for example, quick release capsules, are generally provided. Advantageously, in some embodiments, the articles described herein may be configured to prevent fluid from contacting a component h contained therein (e.g., tissue interfacing component) or payload contained therein until a desired time, e.g., the time at which the component is configured to release from the article to a location internal to a subject (e.g., localize to a tissue wall in the subject). In some embodiments, the article comprises a first compartment and a second compartment not in fluid communication with the first compartment. In some embodiments, the first compartment and second compartment are fluidically isolated. For example, in some cases, the first compartment comprises a mechanism for releasing a component contained within the article and the second compartment comprises the component.
    Type: Application
    Filed: May 17, 2019
    Publication date: November 25, 2021
    Applicants: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc., Novo Nordisk A/S
    Inventors: Robert S. Langer, Carlo Giovanni Traverso, Alex G. Abramson, David Dellal, Christoph Winfried Johannes Steiger, Niclas Roxhed, Ester Caffarel Salvador, Vance Soares, Daniel Minahan, Morten Revsgaard Frederiksen
  • Patent number: 11179341
    Abstract: Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject).
    Type: Grant
    Filed: May 17, 2018
    Date of Patent: November 23, 2021
    Assignees: Massachusetts Institute of Technology, The Brigham and Women's Hospital, Inc.
    Inventors: Carlo Giovanni Traverso, Alex G. Abramson, Ester Caffarel Salvador, Niclas Roxhed, Minsoo Khang, Taylor Bensel, Robert S. Langer
  • Publication number: 20210316300
    Abstract: Disclosed herein is a microfluidic device and a method for transporting and sampling a defined volume of plasma, providing a fluid passageway from an inlet to an outlet comprising a first region with the inlet with a first high flow resistance configured to receive and collect a whole blood sample and to separate plasma; and a second region with the outlet lower flow resistance. The second region is in fluid connection with the first region and configured to meter the separated plasma by comprising a metering channel.
    Type: Application
    Filed: September 5, 2019
    Publication date: October 14, 2021
    Inventors: Anna OHLANDER, Hans Peter STARCK-JOHNSON, Janosch HAUSER, Göran STEMME, Niclas ROXHED