Abstract: A `docking` method based on finite grid forcefield sampling makes use of fast evaluation of interaction energies between molecules, such as macromolecules and ligands. The forcefield used to calculate interaction energies utilizes a potential energy function composed of a 1/r dependent electrostatic term and a (6-12) Lennard-Jones term for Van der Waals interactions. Successful prediction of ligand position and determination of ligand-protein interaction enthalpy is done by mapping potential energy field components of one of the molecules onto a energy field component grids, and mapping interaction field components of another of the two molecules onto interaction component grids.

Abstract: A printer comprising an impact device which is provided with an impact member which is electromechanically driven and whose position or speed is measured by means of a transducer in order to obtain a speed signal which is compared with a reference signal in a comparator. The signal output of the comparator is connected to a signal input of an electrical actuation device for driving the impact member, the actuation of the drive being terminated only after a stop signal has appeared on the signal output of the comparator. An adapted speed of the impact member is obtained in all circumstances in a printer in accordance with the invention.

Abstract: A control device for a matrix printer. At the beginning of a line, a chaining unit is filled with a starting column address, a starting row address and a starting character address, the latter being to address a line buffer containing data of a line of characters. The line buffer supplies a character signal which addresses a character generator having column addresses and row addresses as further sub-addresses. The chaining unit contains data about the relevant row advances and column advances. Between the displacement of the movable member over one column distance, the chaining circuit successively calculates dot data for all recording elements, said data being serially loaded into a dot register. When the next column position is reached, the dot data are used to activate the recording elements.