Patents by Inventor Nico H.J. Pijls

Nico H.J. Pijls has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20200375473
    Abstract: A method for characterizing cardiac valves and prostheses. A method includes inducing cardiac stress. Transvalvular pressure gradient and transvalvular flow are measured while the stress is being induced. Valve function is determined based on the measured transvalvular pressure gradient and transvalvular flow. In some implementations, a transcatheter aortic valve implantation is performed responsive to the determination of valve function.
    Type: Application
    Filed: December 11, 2018
    Publication date: December 3, 2020
    Inventors: Nils P. JOHNSON, Pim A. L. TONINO, K. Lance GOULD, Nico H. J. PIJLS, Richard L. KIRKEEIDE, Daniel T. JOHNSON
  • Patent number: 10716482
    Abstract: Catheter systems and methods for determining blood flow rates based on temperature measurements by thermodilution. The catheter may include a fluid lumen defined between inner and outer tubular members for delivering an indicator fluid, and a guidewire lumen defined by the inner tubular member. The catheter may include fluid infusion openings at the distal end region of the outer tubular member configured to permit the indicator fluid to exit the catheter from the fluid lumen, and a fluid hole located at the distal end region of the inner tubular member configured to permit the indicator fluid to pass from the fluid lumen into the guidewire lumen. A temperature sensor positioned on a guidewire may be positioned within the guidewire lumen to measure the temperature of the indicator fluid entering the guidewire lumen through the fluid hole. A blood flow rate may be calculated based on the measured temperature.
    Type: Grant
    Filed: April 24, 2014
    Date of Patent: July 21, 2020
    Assignee: HEXACATH
    Inventors: James M. Anderson, Jan Weber, Steven J Koch, Timothy S. Girton, Nico H J Pijls, Bernard De Bruyne
  • Patent number: 8715200
    Abstract: The invention relates to a method and a system for determining the blood flow in an individual coronary artery of a patient, wherein the method comprises the steps of positioning a temperature sensor mounted at a distal portion of a guide wire at a distal position in the coronary artery, positioning an infusion catheter in the coronary artery such that the distal end of the infusion catheter is proximally of the temperature sensor, measuring the blood temperature with the temperature sensor, infusing cold indicator fluid with a known infusion rate and known or measurable temperature into the coronary artery by the infusion catheter, measuring the temperature of the mixture of blood and indicator fluid by the temperature sensor, and calculating the coronary blood flow by a formula based on the known and measured quantities. In an extended version, the method comprises steps for relating the calculated coronary flow value to related normal flow values, or related FFR values, or a related flow resistance.
    Type: Grant
    Filed: July 20, 2010
    Date of Patent: May 6, 2014
    Assignee: Radi Medical Systems AB
    Inventor: Nico H. J. Pijls
  • Publication number: 20100286537
    Abstract: The invention relates to a method and a system for determining the blood flow in an individual coronary artery of a patient, wherein the method comprises the steps of positioning a temperature sensor mounted at a distal portion of a guide wire at a distal position in the coronary artery, positioning an infusion catheter in the coronary artery such that the distal end of the infusion catheter is proximally of the temperature sensor, measuring the blood temperature with the temperature sensor, infusing cold indicator fluid with a known infusion rate and known or measurable temperature into the coronary artery by the infusion catheter, measuring the temperature of the mixture of blood and indicator fluid by the temperature sensor, and calculating the coronary blood flow by a formula based on the known and measured quantities. In an extended version, the method comprises steps for relating the calculated coronary flow value to related normal flow values, or related FFR values, or a related flow resistance.
    Type: Application
    Filed: July 20, 2010
    Publication date: November 11, 2010
    Inventor: Nico H.J. PIJLS
  • Patent number: 7775988
    Abstract: The invention relates to a method and a system for determining the blood flow in an individual coronary artery of a patient, wherein the method comprises the steps of positioning a temperature sensor mounted at a distal portion of a guide wire at a distal position in the coronary artery, positioning an infusion catheter in the coronary artery such that the distal end of the infusion catheter is proximally of the temperature sensor, measuring the blood temperature with the temperature sensor, infusing cold indicator fluid with a known infusion rate and known or measurable temperature into the coronary artery by the infusion catheter, measuring the temperature of the mixture of blood and indicator fluid by the temperature sensor, and calculating the coronary blood flow by a formula based on the known and measured quantities. In an extended version, the method comprises steps for relating the calculated coronary flow value to related normal flow values, or related FFR values, or a related flow resistance.
    Type: Grant
    Filed: September 30, 2005
    Date of Patent: August 17, 2010
    Assignee: Radi Medical Systems AB
    Inventor: Nico H.J. Pijls