Patents by Inventor Nico Heins

Nico Heins has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8951792
    Abstract: The present invention relates to a novel hepatocyte-like cell progenitor and/or a novel hepatocyte-like cell derived via definitive endoderm from human blastocyst-derived stem (hBS) cells, to a method for the preparation of such cells and to the potential use of such cells in e.g. pharmaceutical drug discovery and development, toxicity testing, cell therapy and medical treatment. In particular is presented a definitive endoderm derived hepatocyte-like cell with important liver-expressed marker genes and important metabolizing enzymes, as well as drug transporters.
    Type: Grant
    Filed: July 18, 2008
    Date of Patent: February 10, 2015
    Assignee: Cellartis AB
    Inventors: Nico Heins, Gabriella Brolén, Barbara Küppers-Munther
  • Publication number: 20110250686
    Abstract: The present invention relates to a novel hepatocyte-like cell population derived from hBS cells and to the potential use of such heopatocyte-like cells in e.g. medical treatment, drug screening and toxicity testing. Furthermore, the invention relates to 5 hepatoblast-like cells that may have suitable characteristics so that they can be used for the same applications as the hepatocyte-like cells and that furthermore may be used in in vitro studies of hepatogenesis such as early hepatogenesis or hepatoregenerative disorders. Both the hepatocyte-like and the hepatoblast-like cells according to the invention express drug transporter and/or drug metabolising 10 characteristics either at the gene or protein expression level.
    Type: Application
    Filed: June 20, 2011
    Publication date: October 13, 2011
    Applicant: CELLARTIS AB
    Inventors: Nico Heins, Barbara Küppers-Munther, Josefina Edsbagge
  • Publication number: 20100190202
    Abstract: The present disclosure relates to a novel hepatocyte-like cell progenitor and/or a novel hepatocyte-like cell derived via definitive endoderm from human blastocyst-derived stem (hBS) cells, to a method for the preparation of such cells and to the potential use of such cells in, e.g., pharmaceutical drug discovery and development, toxicity testing, cell therapy and medical treatment. In particular is presented a definitive endoderm derived hepatocyte-like cell with important liver-expressed marker genes and important metabolizing enzymes, as well as drug transporters.
    Type: Application
    Filed: July 18, 2008
    Publication date: July 29, 2010
    Applicant: Cellartis AB
    Inventors: Nico Heins, Gabriella Brolén, Barbara Küppers-Munther
  • Publication number: 20090123432
    Abstract: The present invention relates to a novel hepatocyte-like cell progenitor and/or a novel hepatocyte-like cell derived via definitive endoderm from human blastocyst-derived stem (hBS) cells, to a method for the preparation of such cells and to the potential use of such cells in e.g. pharmaceutical drug discovery and development, toxicity testing, cell therapy and medical treatment. In particular is presented a definitive endoderm derived hepatocyte-like cell with important liver-expressed marker genes and important metabolizing enzymes, as well as drug transporters.
    Type: Application
    Filed: July 18, 2008
    Publication date: May 14, 2009
    Applicant: Cellartis AB
    Inventors: Nico Heins, Gabriella Brolen, Barbara Kuppers-Munther
  • Publication number: 20080019950
    Abstract: The present invention relates to a novel hepatocyte-like cell population derived from hBS cells and to the potential use of such heopatocyte-like cells in e.g. medical treatment, drug screening and toxicity testing. Furthermore, the invention relates to hepatoblast-like cells that may have suitable characteristics so that they can be used for the same applications as the hepatocyte-like cells and that furthermore may be used in in vitro studies of hepatogenesis such as early hepatogenesis or hepato-regenerative disorders. Both the hepatocyte-like and the hepatoblast-like cells according to the invention express drug transporter and/or drug metabolising characteristics either at the gene or protein expression level.
    Type: Application
    Filed: June 4, 2007
    Publication date: January 24, 2008
    Applicant: CELLARTIS AB
    Inventors: Nico Heins, Barbara Kuppers-Munther, Josefina Edsbagge
  • Publication number: 20070298016
    Abstract: The present invention relates to methods for obtaining endodermal progenitor cells and further differentiating these to hepatocyte-like cells. Knowledge about the cell composition prior to the initiation of terminal differentiation is used to select one of two different protocols and one of two type of intermediate progenitors depending on the purpose for which the resulting hepatocyte-like cells are needed. Protocol A of the present invention relates to differentiation of extraembryonic-resembling endodermal progenitor cells to hepatocyte-like cells and may be selected when yield and purity of the obtained hepatocyte-like cells is important. Protocol B of the present invention relates to differentiation of mesendodermal-resembling progenitor cells to hepatocyte-like cells and may be selected when quality of the obtained hepatocyte-like cells is important.
    Type: Application
    Filed: September 29, 2005
    Publication date: December 27, 2007
    Inventors: Nico Heins, Henrik Semb, Karolina Akesson, Marie Rehnstrom