Abstract: Methods, compositions, uses and kits can be provided to treat cancer in a subject, which can include administering to the subject an active agent to induce enhanced tumor cell mitosis, and providing, in proximity or immediately after that, a therapy that specifically targets cells in mitosis, such as chemotherapy or radiation.

Abstract: An exemplary catheter can be provided which can include, for example, a first inflation arrangement configured, in operation, to substantially seal and/or anchor the catheter inside the bladder when inflated, a second inflation arrangement configured, in operation, to substantially float in urine when inflated, wherein the second arrangement can be located at a predetermined distance from the first inflation arrangement, and an aperture provided between the first inflation arrangement and the second inflation arrangement, where the first and second arrangements can cause the aperture to be (i) open when the second inflation arrangement can be located at a first position relative to the first inflation arrangement, and (ii) closed when the second inflation arrangement can be located at a second position relative to the first inflation arrangement, and where the second position can be different than the first position.

Abstract: An exemplary catheter can be provided which can include, for example, a first inflation arrangement configured, in operation, to substantially seal and/or anchor the catheter inside the bladder when inflated, a second inflation arrangement configured, in operation, to substantially float in urine when inflated, wherein the second arrangement can be located at a predetermined distance from the first inflation arrangement, and an aperture provided between the first inflation arrangement and the second inflation arrangement, where the first and second arrangements can cause the aperture to be (i) open when the second inflation arrangement can be located at a first position relative to the first inflation arrangement, and (ii) closed when the second inflation arrangement can be located at a second position relative to the first inflation arrangement, and where the second position can be different than the first position.

Abstract: An exemplary system, method and computer-accessible medium for determining a location a radioactive seed(s) within a body, can include, for example receiving first imaging information of the radioactive seed(s) within the body based on a first imaging modality, receiving second imaging information of the radioactive seed(s) within the body based on a second imaging modality, and determining the location of the radioactive seed(s) within the body based on the first and second imaging information. The first imaging modality can be computed tomography, and the second imaging modality can be an ultrasound, which can be a transrectal ultrasound. Third information related to a seed implantation plan for a patient(s) can be received.

Abstract: The invention relates to novel heparanases, heparanase splice variants, and to polynucleotides encoding them. Particularly, the invention relates to Spalax heparanases, and to Spalax and human heparanase splice variants. Heparanase splice variants can be used, for example, to modulate the activity of heparanase in diseases disorders or conditions caused by or associated with the enzymatic activity of heparanase. For instance, a splice variant capable of down regulating the activity of heparanase can be used to treat primary tumors and/or to prevent or treat metastasis.

Abstract: The invention relates to novel heparanases, heparanase splice variants, and to polynucleotides encoding them. Particularly, the invention relates to Spalax heparanases, and to Spalax and human heparanase splice variants. Heparanase splice variants can be used, for example, to modulate the activity of heparanase in diseases disorders or conditions caused by or associated with the enzymatic activity of heparanase. For instance, a splice variant capable of down regulating the activity of heparanase can be used to treat primary tumors and/or to prevent or treat metastasis.