Patents by Inventor Nicola Jo Thelwell

Nicola Jo Thelwell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polynucleotide primers for detecting PIK3CA mutations
    Patent number: 10196692
    Abstract: A polynucleotide comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 3 to 16, 18, 20 to 33, 35 or 37 to 39. A method of detecting the presence or absence of a mutation in the PIK3CA gene, wherein the mutation is one of H1047R, H1047L, E542K and E545K, and preferably ARMS primers are combined with Scorpion primers.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: February 5, 2019
    Assignee: QIAGEN MANCHESTER LIMITED
    Inventors: Ruth Board, Jennifer Haworth, Paul Francis Ravetto, Nicola Jo Thelwell, David Whitcombe
  • Polynucleotide primers for detecting PIK3CA mutations
    Patent number: 10190171
    Abstract: A polynucleotide comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 3 to 16, 18, 20 to 33, 35 or 37 to 39. A method of detecting the presence or absence of a mutation in the PIK3CA gene, wherein the mutation is one of H1047R, H1047L, E542K and E545K, and preferably ARMS primers are combined with Scorpion primers.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: January 29, 2019
    Assignee: QIAGEN MANCHESTER LIMITED
    Inventors: Ruth Board, Jennifer Haworth, Paul Francis Ravetto, Nicola Jo Thelwell, David Whitcombe
  • Polynucleotide primers for detecting PIK3CA mutations
    Patent number: 9863003
    Abstract: A polynucleotide comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 3 to 16, 18, 20 to 33, 35 or 37 to 39. A method of detecting the presence or absence of a mutation in the PIK3CA gene, wherein the mutation is one of H1047R, H1047L, E542K and E545K, and preferably ARMS primers are combined with Scorpion primers.
    Type: Grant
    Filed: October 24, 2013
    Date of Patent: January 9, 2018
    Assignee: QIAGEN MANCHESTER LIMITED
    Inventors: Ruth Board, Jennifer Haworth, Paul Francis Ravetto, Nicola Jo Thelwell, David Whitcombe
  • Method for quantifying human DNA using an internal control
    Patent number: 9328385
    Abstract: The present invention relates to a method for quantifying and/or detecting one or more nucleic acids of a genome in a sample, wherein in an amplification reaction, (i) a first nucleic acid is amplified, the locus that is amplified is a multicopy locus (MCL) within the genome, wherein the locus shares at least 80% sequence identity to a sequence according to SEQ ID NO. 1 over a stretch of 80 base pairs, and wherein the multicopy locus has copies on at least two different chromosomes, (ii) a second nucleic acid that has been added as an internal control (IC) is also amplified, and (iii) the amount of amplification product from the amplification of the first nucleic acid is determined.
    Type: Grant
    Filed: February 20, 2012
    Date of Patent: May 3, 2016
    Assignees: Qiagen GmbH, Qiagen Manchester Limited
    Inventors: Francesca Di Pasquale, Holger Engel, Sascha Strauss, Nicola Jo Thelwell
  • Polynucleotide Primers For Detecting PIK3CA Mutations
    Publication number: 20160040255
    Abstract: A polynucleotide comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 3 to 16, 18, 20 to 33, 35 or 37 to 39. A method of detecting the presence or absence of a mutation in the PIK3CA gene, wherein the mutation is one of H1047R, H1047L, E542K and E545K, and preferably ARMS primers are combined with Scorpion primers.
    Type: Application
    Filed: September 18, 2015
    Publication date: February 11, 2016
    Inventors: Ruth Board, Jennifer Haworth, Paul Francis Ravetto, Nicola Jo Thelwell, David Whitcombe
  • Polynucleotide Primers For Detecting PIK3CA Mutations
    Publication number: 20160032408
    Abstract: A polynucleotide comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 3 to 16, 18, 20 to 33, 35 or 37 to 39. A method of detecting the presence or absence of a mutation in the PIK3CA gene, wherein the mutation is one of H1047R, H1047L, E542K and E545K, and preferably ARMS primers are combined with Scorpion primers.
    Type: Application
    Filed: September 18, 2015
    Publication date: February 4, 2016
    Inventors: Ruth Board, Jennifer Haworth, Paul Francis Ravetto, Nicola Jo Thelwell, David Whitcombe
  • POLYNUCLEOTIDE PRIMERS
    Publication number: 20150211076
    Abstract: A polynucleotide primer comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 1 to 18, 21 to 45 or 74 to 77.
    Type: Application
    Filed: April 9, 2015
    Publication date: July 30, 2015
    Applicant: QIAGEN MANCHESTER LIMITED
    Inventors: David Mark WHITCOMBE, Nicola Jo THELWELL, Paul Francis RAVETTO
  • Polynucleotide primers
    Patent number: 9029084
    Abstract: A polynucleotide primer comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 1 to 18, 21 to 45 or 74 to 77.
    Type: Grant
    Filed: April 4, 2006
    Date of Patent: May 12, 2015
    Assignee: Qiagen Manchester Limited
    Inventors: David Mark Whitcombe, Nicola Jo Thelwell, Paul Francis Ravetto
  • Polynucleotide primers
    Patent number: 8901285
    Abstract: A polynucleotide comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 3 to 16, 18, 20 to 33, 35 or 37 to 39. A method of detecting the presence or absence of a mutation in the PIK3CA gene, wherein the mutation is one of H1047R, H1047L, E542K and E545K, and preferably ARMS primers are combined with Scorpion primers.
    Type: Grant
    Filed: September 29, 2008
    Date of Patent: December 2, 2014
    Assignee: Qiagen Manchester Limited
    Inventors: Ruth Board, Jennifer Ferguson, Paul Francis Ravetto, Nicola Jo Thelwell, David Whitcombe
  • POLYNUCLEOTIDE PRIMERS FOR DETECTING PIK3CA MUTATIONS
    Publication number: 20140141425
    Abstract: A polynucleotide comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 3 to 16, 18, 20 to 33, 35 or 37 to 39. A method of detecting the presence or absence of a mutation in the PIK3CA gene, wherein the mutation is one of H1047R, H1047L, E542K and E545K, and preferably ARMS primers are combined with Scorpion primers.
    Type: Application
    Filed: October 24, 2013
    Publication date: May 22, 2014
    Applicant: QIAGEN MANCHESTER LIMITED
    Inventors: RUTH BOARD, JENNIFER FERGUSON, PAUL FRANCIS RAVETTO, NICOLA JO THELWELL, DAVID WHITCOMBE
  • POLYNUCLEOTIDE PRIMERS
    Publication number: 20110027779
    Abstract: A polynucleotide comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 3 to 16, 18, 20 to 33, 35 or 37 to 39. A method of detecting the presence or absence of a mutation in the PIK3CA gene, wherein the mutation is one of H1047R, H1047L, E542K and E545K, and preferably ARMS primers are combined with Scorpion primers.
    Type: Application
    Filed: September 29, 2008
    Publication date: February 3, 2011
    Inventors: Ruth Board, Jennifer Ferguson, Paul Francis Ravetto, Nicola Jo Thelwell, David Whitcombe
  • Polynucleotide Primers
    Publication number: 20080261219
    Abstract: A polynucleotide primer comprising at least the final six nucleotides of one of the following primer sequences, or a sequence complementary thereto: SEQ. ID NOS. 1 to 18, 21 to 45 or 74 to 77.
    Type: Application
    Filed: April 4, 2006
    Publication date: October 23, 2008
    Applicant: DXS LIMITED
    Inventors: David Mark Whitcombe, Nicola Jo Thelwell, Paul Francis Ravetto