Patents by Inventor Nicola Lucia Pohl

Nicola Lucia Pohl has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AUTOMATED SOLUTION-PHASE ITERATIVE SYNTHESIS
    Publication number: 20110009612
    Abstract: The first method for iterative solution-phase biomolecule synthesis is described. The method requires only 3 or fewer equivalents of building block at each coupling cycle, and incorporates a FSPE step at the end of each coupling/deprotection sequence to eliminate most byproducts.
    Type: Application
    Filed: September 21, 2010
    Publication date: January 13, 2011
    Applicant: IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: NICOLA LUCIA POHL, GISUN PARK
  • Colorimetric monitoring of reactions in solution and solid phase automated and manual systems
    Patent number: 7842511
    Abstract: The present invention relates to the a new protecting group, 4-(O-nitrophthalimido)butyric acid (NPB) that may be attached to a monomer unit during oligosaccharide synthesis such that upon cleavage of this molecule, the solution turns orange. The orange color allows the simple colorimetric monitoring of the completion of the cleavage reaction and, upon collection of the colored fraction, quantification of the amount of the monomer unit that was successfully coupled to the solid phase.
    Type: Grant
    Filed: April 13, 2006
    Date of Patent: November 30, 2010
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Nicola Lucia Pohl, Kwang-Seuk Ko
  • AUTOMATED SOLUTION-PHASE ITERATIVE SYNTHESIS
    Publication number: 20100159604
    Abstract: The first method for iterative solution-phase biomolecule synthesis is described. The method requires only 3 or fewer equivalents of building block at each coupling cycle, and incorporates a FSPE step at the end of each coupling/deprotection sequence to eliminate most byproducts.
    Type: Application
    Filed: June 22, 2007
    Publication date: June 24, 2010
    Applicant: IOWA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: Nicola Lucia Pohl, Gisun Park
  • More stable analog of isopropyl thiogalactoside for induction of protein expression
    Patent number: 7141394
    Abstract: A novel C-glycoside of isopropylthiogalactoside (IPTG), isobutyl-C-galactoside (IBCG), is described. IBCG may be used as an IPTG substitute for increased induction of protein expression of plasmid-based genes for the production of recombinant proteins under the control of the lac promoter. IBCG offers the advantage over IPTG of being stable at ambient temperature.
    Type: Grant
    Filed: April 19, 2004
    Date of Patent: November 28, 2006
    Assignee: Iowa State University Research Foundation, Inc.
    Inventors: Nicola Lucia Pohl, Kwang-Seuk Ko
  • More stable analog of isopropylthiogalactoside for induction of protein expression
    Publication number: 20040224390
    Abstract: A novel C-glycoside of isopropylthiogalactoside (IPTG), isobutyl-C-galactoside (IBCG), is described. IBCG may be used as an IPTG substitute for increased induction of protein expression of plasmid-based genes for the production of recombinant proteins under the control of the lac promoter. IBCG offers the advantage over IPTG of being stable at ambient temperature.
    Type: Application
    Filed: April 19, 2004
    Publication date: November 11, 2004
    Applicant: IOWA STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Nicola Lucia Pohl, Kwang-Seuk Ko