Abstract: Amino acid sequences and nucleotide sequences relating to PDEXV are described. In a preferred aspect, the amino acid sequence comprises the sequence presented as SEQ ID NO:1.

Abstract: Amino acid sequences and nucleotide sequences relating to PDEXV are described. In a preferred aspect, the amino acid sequence comprises the sequence presented as SEQ ID NO:1.

Abstract: This invention provides novel PDE11 genes and polypeptides, and variants, homologues, fragments, and derivatives thereof. This invention also provides vectors and host cells comprising the disclosed nucleotide sequences. This invention further provides antibodies that bind to the PDE11 polypeptides. This invention further yet provides methods for identifying agents that affect the expression or activity of the PDE11 genes and polypeptides. This invention also provides pharmaceutical compositions comprising the PDE11 genes or polypeptides, or inhibitors thereof. This invention additionally provides methods for treating diseases and conditions related to PDE11 activity, or the inhibition thereof.

Abstract: This invention relates to the identification of an orphan G-protein coupled receptor EBI2 (and variants thereof) as a receptor of neuropeptides of the CRF family, and the use of such peptides, e.g. urotensin I or sauvagine (and analogues or mimetics of either one) as modulators for EBI2. It also relates to screening methods to identify agonists and antagonists for this neuropeptide receptor.

Abstract: This invention relates to the identification of an orphan G-protein coupled receptor PFI-011 (and variants thereof) as a receptor of adrenic acid, and the use of adrenic acid (and analogues or mimetics thereof) as modulators for PFI-011. It also relates to screening methods to identify agonists and antagonists for this adrenic acid receptor.

Abstract: This invention provides novel PDE11 genes and polypeptides, and variants, homologues, fragments, and derivatives thereof. This invention also provides vectors and host cells comprising the disclosed nucleotide sequences. This invention further provides antibodies that bind to the PDE11 polypeptides. This invention further yet provides methods for identifying agents that affect the expression or activity of the PDE11 genes and polypeptides. This invention also provides pharmaceutical compositions comprising the PDE11 genes or polypeptides, or inhibitors thereof. This invention additionally provides methods for treating diseases and conditions related to PDE11 activity, or the inhibition thereof.