Abstract: The present application relates to processor-implemented methods for determining a diagnostic outcome comprising receiving signals generated by an array of electro-chemical sensors in solution with a biological sample from a subject, each sensor of the array of electro-chemical sensors configured to generate a signal in response to one or more amplification reactions occurring in the solution, the one or more amplification reactions being indicative of the presence of an RNA host-response; processing the signals received from the array of electro-chemical sensors; based on the processing, assigning at least one value to the sample, the at least one value being indicative of a likelihood of the diagnostic outcome; based on the at least one assigned value, determining the diagnostic outcome.

Abstract: The present application relates to methods for detecting a first allele of a single nucleotide polymorphism (SNP) in a nucleic acid sequence under isothermal conditions using primers specific for said first allele, in particular using Loop mediated isothermal amplification (LAMP), wherein the amplification of a second allele is prevented by using blocking primers.

Abstract: A method is disclosed herein for detecting an amplification reaction in a solution containing a biological sample using an array of ion sensors. The amplification reaction is indicative of the presence of a nucleic acid. The method comprises monitoring a signal from each respective sensor of the array of ion sensors, detecting a change in the signal from a first sensor of the array of ion sensors, and comparing the signal from the first sensor with the signal of at least one neighbouring sensor, the at least one neighbouring sensor being proximate to the first sensor in the array. The method further comprises determining, based on the comparing, that an amplification event has occurred in the solution in the vicinity of the first sensor.

Abstract: The present application relates to methods for detecting a tandem repeat in a nucleic acid sequence under isothermal conditions using primers.

Abstract: The present invention relates to a micro-hotplate device comprising a frame, a membrane, an active area comprising at least one active layer, and a heating structure designed to heat said active layer, said heating structure having concentric tracks and comprising inner tracks (20) and inner spaces (22) and outer tracks (24) and outer spaces (26) as being the one or two tracks and spaces located the furthest away from the center of the heating structure, characterized in that said outer tracks (24) are designed to be located closer to their neighboring tracks and/or are designed to have a width which is lower than those of the inner tracks (20), the width and the spacing of said inner tracks (20) being substantially constant.

Abstract: The present invention relates to a micro-hotplate device comprising a frame, a membrane, an active area comprising at least one active layer, and a heating structure designed to heat said active layer, said heating structure having concentric tracks and comprising inner tracks (20) and inner spaces (22) and outer tracks (24) and outer spaces (26) as being the one or two tracks and spaces located the furthest away from the center of the heating structure, characterized in that said outer tracks (24) are designed to be located closer to their neighboring tracks and/or are designed to have a width which is lower than those of the inner tracks (20), the width and the spacing of said inner tracks (20) being substantially constant.

Abstract: Method an apparatus for providing a thrilling amusement ride to a passenger stemming predominantly from the inducement of a feeling of dropping through the air and falling from the ride's supporting chair. The method includes positioning a passenger in a passenger support or chair of an amusement ride in a forward facing orientation. The passenger support is located at a drop position in a pre-fall orientation. This drop position may be an origination position, or may be a position to which the support is raised. The passenger support, together with the passenger, is tilted forward into a falling orientation which is at a predetermined tilt-angle to the pre-fall orientation. The passenger support, together with the passenger, is dropped from the drop position to a lower position while the passenger support and the passenger are in the forward tilted falling orientation thereby providing a thrilling amusement ride to the passenger.

Abstract: Method and apparatus for providing a thrilling amusement ride to a passenger stemming predominantly from the inducement of a feeling of being propelled downward toward the ground and from the inducement of a feeling of falling from the ride's supporting chair. The method includes positioning a passenger in a passenger support or chair of an amusement ride in a forward facing orientation. The passenger support is located at a drop position in a pre-fall orientation. This drop position may be an origination position, or may be a position to which the support is raised. The passenger support, together with the passenger, is tilted forward into a falling orientation which is at a predetermined tilt-angle to the pre-fall orientation. The passenger support, together with the passenger, is dropped and/or propelled from the drop position to a lower position while the passenger support and the passenger are in the forward tilted falling orientation thereby providing a thrilling amusement ride to the passenger.

Abstract: The timepiece (42) includes within the case (44) an electronic compass and a sighting device formed of two sighting marks (14, 15) arranged in the upper portion of the case (44) diametrically opposite each other and defining a reference axis of the case (44). The optical means formed by three light emitting diodes (54, 55, 56) are arranged on the surface of the case (44) in a peripheral region situated at six o'clock for warning or informing a user performing a sighting that the reference axis of the sighting device is aligned with a given azimuthal direction. In another embodiment, instead of the optical means, acoustic means or a buzzer are provided, capable of providing a vibration which is audible or perceptible by a user's body.