Patents by Inventor Nicolaas M. J. Vermuelen

Nicolaas M. J. Vermuelen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Quantification of bacteria using a nucleic acid hybridization assay
    Patent number: 5334501
    Abstract: This invention provides for a method of quantifying bacteria using a bacterial specific nucleic acid probe which is complementary to a unique and highly conserved region of the 16S ribosomal RNA (rRNA) of bacteria. This probe permits the rapid detection of 16S rRNA in a sample and by comparison with known standards, one can estimate the total bacterial count in the sample. The method is accurate and reproducible and conducted at temperatures of between about 120.degree. to about 40.degree. C.
    Type: Grant
    Filed: April 1, 1993
    Date of Patent: August 2, 1994
    Assignee: Microprobe Corporation
    Inventors: Trevor H. Adams, Dennis E. Schwartz, Nicolaas M. J. Vermuelen, Roy H. Kanemoto