Patents by Inventor Nicolaj Stroeyer Christophersen

Nicolaj Stroeyer Christophersen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF PLURIPOTENT MARKERS TO DETECT CONTAMINATING RESIDUAL UNDIFFERENTIATED PLURIPOTENT STEM CELLS
    Publication number: 20230340595
    Abstract: The present invention relates to a method of screening a cell population for contaminating residual undifferentiated stem cells by detecting the expression of one or more markers in the cell population, which expression is effectively silenced as PSCs are differentiated into specialized cells of either of the three germ layers.
    Type: Application
    Filed: March 1, 2021
    Publication date: October 26, 2023
    Inventors: Juan Carlos Villaescusa Ramirez, Nicolaj Stroeyer Christophersen, Fabian Vinzenz Roske, Paschalis Efstathopoulos
  • Generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors
    Patent number: 11274280
    Abstract: The present invention relates to generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors. The present invention also relates to functional beta cells produced by said methods and uses of said beta cells.
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: March 15, 2022
    Assignee: Novo Nordisk A/S
    Inventors: Nicolaj Stroeyer Christophersen, Ulrik Doehn, Mattias Hansson
  • GENERATION OF FUNCTIONAL BETA CELLS FROM HUMAN PLURIPOTENT STEM CELL-DERIVED ENDOCRINE PROGENITORS
    Publication number: 20210230554
    Abstract: The present invention relates to method of generation of functional mature beta cells from human pluripotent stem cell-derived endocrine progenitors. The present invention also relates to functional mature beta cells produced by said methods and uses of said mature beta cells for treating diabetes.
    Type: Application
    Filed: August 30, 2018
    Publication date: July 29, 2021
    Inventors: Nicolaj Stroeyer Christophersen, Ulrik Doehn, Mattias Hansson
  • Generation of Endocrine Progenitor Cells from Human Pluripotent Stem Cells Using Small Molecules
    Publication number: 20200002670
    Abstract: The present invention relates to differentiation of stem cells into a homogeneous endocrine progenitor cell population suitable for further differentiation into pancreatic beta-cells. The present invention provides methods for obtaining NGN3/NKX2.2 double positive endocrine progenitor cells by exposing precursor cells to a TGF-? type I receptor inhibitor, a BMP antagonist, an adenylate cyclase activator and nicotinamide and/or exposing to the precursor cells to a selection of small molecules.
    Type: Application
    Filed: August 20, 2019
    Publication date: January 2, 2020
    Inventors: Ulrik Doehn, Nicolaj Stroeyer Christophersen, Jenny Ekberg
  • Generation of Functional Beta Cells From Human Pluripotent Stem Cell-Derived Endocrine Progenitors
    Publication number: 20190085295
    Abstract: The present invention relates to generation of functional beta cells from human pluripotent stem cell-derived endocrine progenitors. The present invention also relates to functional beta cells produced by said methods and uses of said beta cells.
    Type: Application
    Filed: February 24, 2017
    Publication date: March 21, 2019
    Applicant: Novo Nordisk A/S
    Inventors: Nicolaj Stroeyer Christophersen, Ulrik Doehn, Mattias Hansson
  • Generation of Endocrine Progenitor Cells from Human Pluripotent Stem Cells Using Small Molecules
    Publication number: 20160208215
    Abstract: The present invention relates to differentiation of stem cells into a homogeneous endocrine progenitor cell population suitable for further differentiation into pancreatic beta-cells. The present invention provides methods for obtaining NGN3/NKX2.2 double positive endocrine progenitor cells by exposing precursor cells to a TGF-? type I receptor inhibitor, a BMP antagonist, an adenylate cyclase activator and nicotinamide and/or exposing to the precursor cells to a selection of small molecules.
    Type: Application
    Filed: August 29, 2014
    Publication date: July 21, 2016
    Inventors: Ulrik Doehn, Nicolaj Stroeyer Christophersen, Jenny Ekberg