Patents by Inventor Nicolas Cohen

Nicolas Cohen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • USE OF GILZ PROTEIN EXPRESSED IN DENDRITIC CELLS TO MODULATE AN ANTIGEN-SPECIFIC IMMUNE RESPONSE
    Publication number: 20120308515
    Abstract: A pharmaceutical composition comprising at least dendritic cells modified with a molecule selected from the group consisting of: a GILZ protein or a functional fragment of at least 5 consecutive amino acids of said protein; a small interfering RNA (siRNA) targeting the GILZ transcript or an antisense oligodeoxynucleotide complementary to said transcript; and a recombinant expression vector containing a polynucleotide encoding said GILZ protein, said fragment, said siRNA or said antisense oligodeoxynucleotide complementary to said transcript and a pharmaceutically acceptable carrier. In addition, a method for treatment of autoimmune diseases, inflammatory diseases, allergies, transplant rejection and graft-versus-host disease, cancers or pathogenic microorganism infections by administering an effective amount of said pharmaceutical composition to a subject in need thereof.
    Type: Application
    Filed: May 10, 2012
    Publication date: December 6, 2012
    Applicant: Assistance Publique - Hopitaux De Paris
    Inventors: Dominique EMILIE, Nicolas Cohen, François Lemoine
  • Use of GILZ protein expressed in dendritic cells to modulate an antigen-specific immune response
    Patent number: 8198235
    Abstract: The invention concerns the use of at least one: a) a GILZ protein, a functional fragment of at least 5 consecutive amino acids of said protein, a GILZ modulator, or a recombinant vector expressing same, isolated or expressed in modified dendritic cells, and b) an antigen of interest and/or a molecule allowing targeting and/or passage of the plasmic membrane of dendritic cells, to prepare a medicine for preventing and/or treating autoimmune, inflammatory diseases, allergies, graft rejection and graft-versus-host disease, cancers and pathogenic micro-organism infections.
    Type: Grant
    Filed: September 9, 2005
    Date of Patent: June 12, 2012
    Assignee: Assistance Publique-Hopitaux de Paris
    Inventors: Dominique Emilie, Nicolas Cohen, François Lemoine
  • USE OF GILZ PROTEIN EXPRESSED IN DENDRITIC CELLS TO MODULATE AN ANTIGEN-SPECIFIC IMMUNE RESPONSE
    Publication number: 20090028875
    Abstract: The invention concerns the use of at least one: a) a GILZ protein, a functional fragment of at least 5 consecutive amino acids of said protein, a GILZ modulator, or a recombinant vector expressing same, isolated or expressed in modified dendritic cells, and b) an antigen of interest and/or a molecule allowing targeting and/or passage of the plasmic membrane of dendritic cells, to prepare a medicine for preventing and/or treating autoimmune, inflammatory diseases, allergies, graft rejection and graft-versus-host disease, cancers and pathogenic micro-organism infections.
    Type: Application
    Filed: September 9, 2005
    Publication date: January 29, 2009
    Applicant: Assistance Publique-Hopitaux De Paris
    Inventors: Dominique Emilie, Nicolas Cohen, Francois Lemoine