Abstract: Sports boot including: an inner boot; an exogenous shell, the dimensions of which allow the inner boot to be inserted into or extracted from it, the exogenous shell strengthening the inner boot and allowing it to be attached to a piece of sports equipment. The exogenous shell includes a sole, a forward part of an upper able to pivot with respect to the sole about a first articulation, and a rear part of an upper which is able to pivot with respect to the sole about a second articulation. The sole includes a continuous inner relief pattern having longitudinally-extending ribs separated by longitudinally-extending grooves extending continuously along an entire length of the sole. The inner boot includes a sole with a corresponding relief pattern, so as to position laterally and vertically the inner boot in the exogenous shell.

Abstract: Sports boot including: an inner boot; an exogenous shell, the dimensions of which allow the inner boot to be inserted into or extracted from it, the exogenous shell strengthening the inner boot and allowing it to be attached to a piece of sports equipment. The exogenous shell includes a sole, a forward part of an upper able to pivot with respect to the sole about a first articulation, and a rear part of an upper which is able to pivot with respect to the sole about a second articulation. The sole includes a continuous inner relief pattern having longitudinally-extending ribs separated by longitudinally-extending grooves extending continuously along an entire length of the sole. The inner boot includes a sole with a corresponding relief pattern, so as to position laterally and vertically the inner boot in the exogenous shell.

Abstract: Sports boot comprising: an inner boot (3); an exogenous shell (1), the dimensions of which allow said inner boot (3) to be inserted into or extracted from it, said exogenous shell strengthening said inner boot and allowing it to be attached to a piece of sports equipment; wherein said exogenous shell comprises a sole (10), a forward part of an upper (11) able to pivot with respect to said sole (10) about a first articulation (110), and a rear part of an upper (12) which is able to pivot with respect to said sole (10) about a second articulation (120).

Abstract: Sports boot comprising: an inner boot (3); an exogenous shell (1), the dimensions of which allow said inner boot (3) to be inserted into or extracted from it, said exogenous shell strengthening said inner boot and allowing it to be attached to a piece of sports equipment; wherein said exogenous shell comprises a sole (10), a forward part of an upper (11) able to pivot with respect to said sole (10) about a first articulation (110), and a rear part of an upper (12) which is able to pivot with respect to said sole (10) about a second articulation (120).

Abstract: In various embodiments, systems and methods are provided for increasing the likelihood of a sustained virological response or “cure” using a model of patient physiology incorporating a subjects race, gender, age, weight, concomitant medicines and disease state, immune response status, and responsiveness to drug therapies to simultaneously characterize the change in viral burden in the subject in terms of velocity of viral load decline. In an embodiment, once viral load in a subject is below a physical measurement limit, the model can extrapolate the subject's observed viral velocity toward a physiological target shown to be highly correlated with “cure.” In further embodiments, the model can be used for personalized medicine—“the right drug at the right dose for the right treatment duration for the right patient.” Accordingly, the model can provide optimal value for treatment and reducing the high cost of side effects.