Patent number: 6627650
Abstract: A compound of formula (I):
wherein:
R represents hydrogen, optionally substituted alkyl or alkenyl,
R1 to R8, which may be identical or different, each represents hydrogen, optionally substituted alkyl, hydroxy, acyloxy, optionally substituted amino, carboxy, optionally substituted alkoxy, or alkenyloxy, or one of R1 to R8 forms, with another of R1 to R8 that is adjacent, an alkylenedioxy group,
X represents oxygen or NR16 wherein R16 represents hydrogen, alkyl, aryl or arylalkyl,
R9 represents hydrogen, aryl, heteroaryl, or optionally substituted, saturated or unsaturated alkyl,
an isomer thereof, or an addition salt thereof with a pharmaceutically acceptable acid or base.
Medicinal products containing the same which are useful as anti-cancer agents.
Type:
Grant
Filed:
June 13, 2002
Date of Patent:
September 30, 2003
Assignee:
Les Laboratoires Servier
Inventors:
Michel Wierzbicki, Marie-Françoise Boussard, Anne Rousseau, Ghanem Atassi, John Hickman, Alain Pierre, Stéphane Leonce, Nicolas Guilbaut, Laurence Kraus-Berthier