Patents by Inventor Nicolas Inguimbert

Nicolas Inguimbert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • HEXOKINASE-DERIVED PEPTIDES AND THERAPEUTICAL USES THEREOF
    Publication number: 20240228987
    Abstract: The inventors previously demonstrated that mitochondrial VDAC1 directly induces Schwann cell demyelination via MAPK and c-jun activation after sciatic nerve injury and diabetic neuropathy and CMT1A. They found that reduction of mitochondrial calcium release by VDAC1 blocking strongly reduces the number of demyelinating Schwann cell in vivo and improve nerve conduction and neuromuscular activity in diabetic, Guillain-Barre syndrome and Charcot-Marie Tooth disease models. Herein, the inventors precisely map the binding region of the N-terminal HK-1 helix through an ala scan completed by a deletion study. Furthermore, they optimized the HK-derived peptide through stabilization of the helix by replacement of non-essential amino acids by the a-aminoisobutyric acid (Aib) known as a helix inducer. Additionally, they described an in-house cellular screening assay based on the ability of MJ to detach HK from VDAC that allows to determine the peptide potency.
    Type: Application
    Filed: May 25, 2022
    Publication date: July 11, 2024
    Inventors: Nicolas TRICAUD, Nicolas INGUIMBERT, Benoît GAUTIER
  • Derivatives of 4,4?-dithiobis-(3-aminobutane-1-sulfonates) and compositions comprising the same
    Patent number: 7582797
    Abstract: The invention relates to derivatives of 4,4?-dithiobis-(3-aminobutane-1-sulfonates) of formula (1), of use for the treatment and prevention of primary and secondary arterial hypertension.
    Type: Grant
    Filed: August 6, 2004
    Date of Patent: September 1, 2009
    Assignee: Institute National de la Sante et de la Recherche Medicale (Inserm)
    Inventors: Bernard Pierre Roques, Nicolas Inguimbert, Marie-Claude Fournie-Zaluski, Pierre Corvol, Catherine Llorens-Cortes
  • Novel derivatives of 4,4' dithiobis-(3-aminobutane-1-1-sulfonates) and compositions comprising the same
    Publication number: 20060205695
    Abstract: The invention relates to derivatives of 4,4?-dithiobis-(3-aminobutane-1-sulfonates) of formula (1), of use for the treatment and prevention of primary and secondary arterial hypertension.
    Type: Application
    Filed: August 6, 2004
    Publication date: September 14, 2006
    Applicant: Institut Natinal de la Sante et de la Rechereche (Inserm)
    Inventors: Bernard Roques, Nicolas Inguimbert, Marie-Claude Fournie-Zaluski, Pierre Corvol, Catherine Llorens-Cortes
  • Amino acid derivatives and use thereof as NEP, ACE and ECE inhibitors
    Patent number: 6716852
    Abstract: The invention relates to compounds of formula (I): wherein 0≦n≦3, 0≦m≦6, R3 and R4 together form phenyl, B represents heteroaryl, R1 and R2 represent hydrogen or groups as defined in the description. and medicinal products containing the same which are useful in treating or preventing arterial hypertension and cardiovascular diseases.
    Type: Grant
    Filed: August 12, 2002
    Date of Patent: April 6, 2004
    Assignees: Les Laboratories Servier, Institut National de la Recherche Medicale
    Inventors: Bernard P. Roques, Marie-Claude Fournie-Zaluski, Nicolas Inguimbert, Hervé Poras, Elizabeth Scalbert, Caroline Bennejean, Pierre Renard
  • Amino acid derivatives and use thereof as nep, ace and ece inhibitors
    Publication number: 20030055086
    Abstract: Compounds of formula (I): 1
    Type: Application
    Filed: August 12, 2002
    Publication date: March 20, 2003
    Inventors: Bernard P. Roques, Marie-Claude Fournie-Zaluski, Nicolas Inguimbert, Herve Poras, Elizabeth Scalbert, Caroline Bennejean, Pierre Renard