Abstract: The present invention relates to a compound of formula (I), a tautomer, an enantiomer or a diastereomer thereof, wherein R1, R2, R3 and X have the same meaning as that defined in the claims and the description. The present invention also relates to uses of such compounds as inhibitors of bacterial adhesion and biofilm formation on a surface, methods ex-vivo for preventing bacterial growth in biofilm formation and the use of such compounds in diagnosing or prognosing bacterial infections.

Abstract: New pyrimidine derivatives together with a membrane penetrating agent, optionally with a detectable isotope and pharmaceutical composition for use in treatment or prevention of Gram-negative bacterial infection in a host mammal in need of such treatment or prevention and use as inhibitors of Gram-negative biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers. New pyrimidine derivatives together with a membrane penetrating agent; for use as radiotracer in diagnosing or prognosing Gram-negative bacterial infection in a host mammal.

Abstract: New pyrimidine derivatives together with a membrane penetrating agent, optionally with a detectable isotope and pharmaceutical composition for use in treatment or prevention of Gram-negative bacterial infection in a host mammal in need of such treatment or prevention and use as inhibitors of Gram-negative biofilm formation on a surface of biomaterial or medical device, particularly of cardiovascular device such as prosthetic heart valve or pacemakers. New pyrimidine derivatives together with a membrane penetrating agent; for use as radiotracer in diagnosing or prognosing Gram-negative bacterial infection in a host mammal.

Abstract: A steering column for a motor vehicle comprises a casing unit, which serves to rotatably mount a steering spindle section adjoining a steering-wheel-side end, and at least one support piece which can be fastened at one side to a motor vehicle part fixed with respect to the body and which is or can be fixedly connected at the other side to the casing unit. At least one rupturing region is formed, along which, when a displacement force which exceeds a predefined release force acts in the direction of the longitudinal axis of the steering spindle section adjoining the steering-wheel-side end, the connection of the support piece to the casing unit or the support piece can be ruptured, wherein a displacement of the casing unit relative to the part fixed with respect to the body takes place.

Abstract: A steering column for a motor vehicle comprises a casing unit, which serves to rotatably mount a steering spindle section adjoining a steering-wheel-side end, and at least one support piece which can be fastened at one side to a motor vehicle part fixed with respect to the body and which is or can be fixedly connected at the other side to the casing unit. At least one rupturing region is formed, along which, when a displacement force which exceeds a predefined release force acts in the direction of the longitudinal axis of the steering spindle section adjoining the steering-wheel-side end, the connection of the support piece to the casing unit or the support piece can be ruptured, wherein a displacement of the casing unit relative to the part fixed with respect to the body takes place.