Patents by Inventor Nicolas James Lawrence

Nicolas James Lawrence has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Materials and methods for synthesizing stilbenes
    Publication number: 20040143023
    Abstract: The present invention relates materials and methods for synthesizing stilbenes, and in particular to processes for the synthesis of substituted stilbenes such as combretastatin A4. The present invention relates in particular to methods which are stereoselective for either the cis or the trans isomer of the substituted stilbene, using a Perkin-type condensation of an arylacetic acid and a substituted benzaldehyde, followed by a decarboxylation reaction to produce the substituted cis-stilbenes or a Suzuki-type reaction involving a Z or E-ethenyl halide and a substituted boronic acid in the presence of a palladium catalyst to produce specifically either the Z or E-isomer of substituted stilbenes.
    Type: Application
    Filed: March 3, 2004
    Publication date: July 22, 2004
    Inventors: John Anthony Hadfield, Alan Thomson McGown, Keira Gaukroger, Lucy Annette Hepworth, Nicolas James Lawrence