Abstract: An epidermal tridimensional model exhibiting differentiating keratinocytes in a reconstituted stratum corneum model is disclosed. The model, which contains a cancer therapeutic at an amount effective to simulate chronic drug exposure, can be used to evaluate the potential of cancer therapeutics to produce skin related side effects. The method can also be used to evaluate the efficacy of a composition in reducing the effects of cancer therapeutics on skin.

Abstract: Disclosed is an acoustic transducer for converting a sound signal into an electric signal, including a mobile element movable under the effect of the sound signal, a fixed element opposite the mobile element, a recess, and a dissipative element between the mobile and fixed elements. The coupled system has a natural frequency corresponding to a resonance frequency of the transducer set at maximum sensitivity. The mobile element, the fixed element, the dissipative element and the recess are configured so the quality factor of the acoustic transducer>2. The recess has a straight prismatic, cylindrical, or frustoconical shape, the mobile element forming a first base of the prism, cylinder, or frustum, the fixed element being inside the prism, cylinder or frustum, over the second base of the prism, cylinder or frustum. Such a transducer also incorporates an analogue filtering function for filtering the signal around the natural frequency of same.

Abstract: Disclosed is an acoustic transducer for converting a sound signal into an electric signal, including a mobile element movable under the effect of the sound signal, a fixed element opposite the mobile element, a recess, and a dissipative element between the mobile and fixed elements. The coupled system has a natural frequency corresponding to a resonance frequency of the transducer set at maximum sensitivity. The mobile element, the fixed element, the dissipative element and the recess are configured so the quality factor of the acoustic transducer>2. The recess has a straight prismatic, cylindrical, or frustoconical shape, the mobile element forming a first base of the prism, cylinder, or frustum, the fixed element being inside the prism, cylinder or frustum, over the second base of the prism, cylinder or frustum. Such a transducer also incorporates an analogue filtering function for filtering the signal around the natural frequency of same.