Patents by Inventor Nicolas Levy
Nicolas Levy has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 11926178Abstract: Tire (1) comprising a tread (8), the tire comprising at least one groove (2), at least one wear indicator (3) disposed in the groove (2), the wear indicator comprising a contact face (7) intended to come into contact with a roadway when the tire reaches a wear limit, the groove (2) comprising a texture (4) produced integrally with a bottom (10) of this groove (2), said texture (4) surrounding the wear indicator (3) and contrasting with the contact face (7) of the wear indicator.Type: GrantFiled: March 25, 2016Date of Patent: March 12, 2024Assignee: COMPAGNIE GENERALE DES ETABLISSEMENTS MICHELINInventors: Olivier Muhlhoff, Hélène Emorine, Arnaud Larregain, Nicolas Levy
-
Publication number: 20180072107Abstract: Tire (1) comprising a tread (8), the tire comprising at least one groove (2), at least one wear indicator (3) disposed in the groove (2), the wear indicator comprising a contact face (7) intended to come into contact with a roadway when the tire reaches a wear limit, the groove (2) comprising a texture (4) produced integrally with a bottom (10) of this groove (2), said texture (4) surrounding the wear indicator (3) and contrasting with the contact face (7) of the wear indicator.Type: ApplicationFiled: March 25, 2016Publication date: March 15, 2018Inventors: Olivier MUHLHOFF, Helene EMORINE, Arnaud LARREGAIN, Nicolas LEVY
-
Publication number: 20170368134Abstract: The invention relates to a proteasome inhibitor for use for treating and/or preventing a disorder related to an accumulation of a non-degraded abnormal protein, particularly a premature ageing disorder. The invention also relates to the use of proteasome inhibitors for attenuating physiological ageing. The invention also relates to the use of proteasome inhibitors in the treatment and/or prevention of age-related disorders and their metabolic consequences. The invention also relates to the dermato logical, dermo cosmetic or cosmetic use of a proteasome inhibitor for preventing and/or attenuating skin ageing. The invention also relates to the use of proteasome inhibitors in the treatment of cancer.Type: ApplicationFiled: January 14, 2016Publication date: December 28, 2017Inventors: Nicolas Levy, Pierre Cau, Annachiara De Sandre-Giovannoli, Karim Harhouri, Sophie Perrin, Claire Navarro, Aymeric Chartier, Martine Simonelig
-
Patent number: 9545412Abstract: This invention relates to a composition comprising an anti-HIV treatment and a treatment for side effects of said anti-HIV treatment in an HIV-infected patient. This invention is, for example, very useful in the treatment of side effects caused by certain anti-HIV treatments, for example premature aging and lipodystrophy, which can be caused by protease inhibitors or reverse transcriptase inhibitors. The composition of this invention includes at least one hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, at least one farnesyl-pyrophosphate synthase inhibitor, and at least one anti-HIV agent. One of the processes for treating an HIV-infected patient includes, in any order, the following steps: (i) administration of a mixture including at least one hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and at least one farnesyl-pyrophosphate synthase inhibitor and (ii) administration of an anti-HIV agent, in which the administrations are concomitant, successive or alternative.Type: GrantFiled: June 8, 2015Date of Patent: January 17, 2017Assignee: UNIVERSITE D'AIX-MARSEILLEInventors: Pierre Cau, Nicolas Levy
-
Patent number: 9422607Abstract: The present invention relates to a method for analyzing in vitro D4Z4 tandem repeat arrays of nucleic acid contained on nucleic acid representative of chromosomes, in particular on nucleic acid representative of Human chromosomes 4 and 10, and to a kit therefore. Said method is in particular suitable for determining the number of D4Z4 repeat units in said D4Z4 repeat arrays. Said method is based on stretching of nucleic acid and in particular on Molecular Combing and relies on the use of probes, especially nucleic acid probes, with a particular design. The invention also relates to a method for providing tools for the diagnosis of facioscapulohumeral muscular dystrophy (FSHD) and to a diagnostic kit therefore. The invention further relates to a method for identifying biochemical events and/or genetic in regions containing such tandem repeat arrays.Type: GrantFiled: September 25, 2009Date of Patent: August 23, 2016Assignees: UNIVERSITE D'AIX-MARSEILLE, ASSISTANCE PUBLIQUE DES HOPITAUX MARSEILLE, GENOMIC VISIONInventors: Pierre Walrafen, Aaron Bensimon, Nicolas Levy
-
Publication number: 20150342970Abstract: This invention relates to a composition comprising an anti-HIV treatment and a treatment for side effects of said anti-HIV treatment in an HIV-infected patient. This invention is, for example, very useful in the treatment of side effects caused by certain anti-HIV treatments, for example premature aging and lipodystrophy, which can be caused by protease inhibitors or reverse transcriptase inhibitors. The composition of this invention includes at least one hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, at least one farnesyl-pyrophosphate synthase inhibitor, and at least one anti-HIV agent. One of the processes for treating an HIV-infected patient includes, in any order, the following steps: (i) administration of a mixture including at least one hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and at least one farnesyl-pyrophosphate synthase inhibitor and (ii) administration of an anti-HIV agent, in which the administrations are concomitant, successive or alternative.Type: ApplicationFiled: June 8, 2015Publication date: December 3, 2015Inventors: Pierre CAU, Nicolas Levy
-
Publication number: 20150247196Abstract: The present invention provides a method for determining all the molecular causes of Inherited Neuromuscular Disorders comprising determining a number of copy number variation(s), and/or determining a number of point mutation(s) on a physiological sample comprising a genome of a subject.Type: ApplicationFiled: September 6, 2013Publication date: September 3, 2015Inventors: Pascal Soularue, David Atlan, Valerie Allamand, Marc Bartoli, Christophe Beroud, Gisele Bonne, Patrice Bourgeois, Sebahattin Cirak, Mireille Cossee, Rafael De Cid, Martin Krahn, Nicolas Levy, Francesco Muntoni, Isabelle Richard
-
Patent number: 9072757Abstract: The invention relates to the use of a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and of a farnesyl-pyrophosphate synthase inhibitor, or of one of their associated physiologically acceptable salts, in the preparation of a composition, particularly a pharmaceutical composition, for use in the treatment of human or animal, pathological or nonpathological situations related to the accumulation and/or the persistence of prenylated proteins in cells, such as during progeria (Hutchinson-Gilford syndrome), restrictive dermopathy or physiological ageing.Type: GrantFiled: June 19, 2013Date of Patent: July 7, 2015Assignees: UNIVERSITE D'AIX-MARSEILLE, ASSOCIATION FRANCAISE CONTRE LES MYOPATHIES (AFM), ASSISTANCE PUBLIQUE HOPITAUX DE MARSEILLE, UNIVERSIDAD DE OVIEDOInventors: Nicolas Levy, Pierre Cau, Carlos Lopez-Otin
-
Publication number: 20150105352Abstract: The invention relates to the use of a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and of a farnesyl-pyrophosphate synthase inhibitor, or of one of their associated physiologically acceptable salts, in the preparation of a composition, particularly a pharmaceutical composition, for use in the treatment of human or animal, pathological or nonpathological situations related to the accumulation and/or the persistence of prenylated proteins in cells, such as during progeria (Hutchinson-Gilford syndrome), restrictive dermopathy or physiological ageing.Type: ApplicationFiled: December 18, 2014Publication date: April 16, 2015Inventors: Nicolas LEVY, Pierre CAU, Carlos LOPEZ-OTIN
-
Patent number: 8955565Abstract: Road-going assembly consisting of a vehicle comprising a front axle and a rear axle, and of a set of tires which are mounted on their mounting rim in order to be fitted to the front axle and the rear axle of this vehicle, the tires of the rear axle having grooves the mean depths of which are at least equal to 3 mm and at most equal to 5 mm, the tires of the front axle having grooves the mean depths of which are greater than 5 mm, this road-going assembly having, at least in the case of the rear axle, static setups (camber, toe-in) of close to zero, that is to say a camber of each wheel-tire assembly on the said axle of between ?0.8 degrees and +0.8 degrees and a toe-in at each wheel of between ?0.15 degrees and +0.15 degrees, the static setups of the tires of one and the same axle being equal in terms of absolute value and symmetric with respect to a plane perpendicular to the road surface.Type: GrantFiled: March 17, 2009Date of Patent: February 17, 2015Assignees: Compagnie Generale des Etablissements, Michelin Recherche et Technique S.A.Inventors: Frédéric Perrin, Nicolas Levy
-
Patent number: 8586560Abstract: The present invention relates to methods for restoring the function of a mutated dysferlin comprising the step of preventing splicing of one or more exons which encode amino acid sequences that cause said dysferlin dysfunction. Particularly, the splicing of exon 32 is prevented. The present invention also relates to a method for treating a dysferlinopathy in a patient in need thereof, comprising the step of administering to said patient antisense oligonucleotides complementary to nucleic acid sequences that are necessary for correct splicing of one or more exons which encode amino acid sequences that cause said dysfunction. Particularly, the splicing of exon 32 is prevented.Type: GrantFiled: October 18, 2010Date of Patent: November 19, 2013Assignees: Institut National de la Sante et de la Recherche Medicale (INSERM), Universite de la Mediterranee—Aix Marseille IIInventors: Nicolas Levy, Martin Krahn, Marc Bartoli, Luis Garcia
-
Publication number: 20130281408Abstract: The invention relates to the use of a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and of a farnesyl-pyrophosphate synthase inhibitor, or of one of their associated physiologically acceptable salts, in the preparation of a composition, particularly a pharmaceutical composition, for use in the treatment of human or animal, pathological or nonpathological situations related to the accumulation and/or the persistence of prenylated proteins in cells, such as during progeria (Hutchinson-Gilford syndrome), restrictive dermopathy or physiological ageing.Type: ApplicationFiled: June 19, 2013Publication date: October 24, 2013Inventors: Nicolas Levy, Pierre Cau, Carlos Lopez-Otin
-
Patent number: 8518914Abstract: The invention relates to the use of a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and of a farnesyl-pyrophosphate synthase inhibitor, or of one of their associated physiologically acceptable salts, in the preparation of a composition, particularly a pharmaceutical composition, for use in the treatment of human or animal, pathological or nonpathological situations related to the accumulation and/or the persistence of prenylated proteins in cells, such as during progeria (Hutchinson-Gilford syndrome), restrictive dermopathy or physiological aging.Type: GrantFiled: July 5, 2007Date of Patent: August 27, 2013Assignees: Universite de la Mediterranee AIX-Marseille II, Association Francaise Contre les Myophathies (AFM), Assistance Publique Hopitaux de Marseille, Universidad de OviedoInventors: Nicolas Levy, Pierre Cau, Carlos Lopez-Otin
-
Publication number: 20130130924Abstract: The present invention relates to a method for analysing in vitro D4Z4 tandem repeat arrays of nucleic acid contained on nucleic acid representative of chromosomes, in particular on nucleic acid representative of Human chromosomes 4 and 10, and to a kit therefore. Said method is in particular suitable for determining the number of D4Z4 repeat units in said D4Z4 repeat arrays. Said method is based on stretching of nucleic acid and in particular on Molecular Combing and relies on the use of probes, especially nucleic acid probes, with a particular design. The invention also relates to a method for providing tools for the diagnosis of facioscapulohumeral muscular dystrophy (FSHD) and to a diagnostic kit therefore. The invention further relates to a method for identifying biochemical events and/or genetic in regions containing such tandem repeat arrays.Type: ApplicationFiled: September 25, 2009Publication date: May 23, 2013Inventors: Pierre Walrafen, Anne Vannier, Aaron Bensimon, Nicolas Lévy
-
Publication number: 20120208865Abstract: The present invention relates to methods for restoring the function of a mutated dysferlin comprising the step of preventing splicing of one or more exons which encode amino acid sequences that cause said dysferlin dysfunction. Particularly, the splicing of exon 32 is prevented. The present invention also relates to a method for treating a dysferlinopathy in a patient in need thereof, comprising the step of administering to said patient antisense oligonucleotides complementary to nucleic acid sequences that are necessary for correct splicing of one or more exons which encode amino acid sequences that cause said dysfunction. Particularly, the splicing of exon 32 is prevented.Type: ApplicationFiled: October 18, 2010Publication date: August 16, 2012Inventors: Nicolas Levy, Martin Krahn, Marc Bartoli, Luis Garcia
-
Publication number: 20110165092Abstract: The subject matter of the invention is a cosmetic and/or dermatological composition for use in the treatment of skin and/or hair disorders. More particularly, the invention relates to a cosmetic and/or dermatological composition comprising an inhibitor of hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase, an inhibitor of farnesyl pyrophosphate synthase, or an inhibitor of one of the physiologically acceptable salts thereof and a cosmetic and/or dermatological product. The present invention finds, for example, a very advantageous use in the treatment of the effects of early ageing, in particular in terms of the skin and the hair system.Type: ApplicationFiled: December 31, 2008Publication date: July 7, 2011Applicant: Universite de la Mediterranee, Aix-Marseille IIInventors: Pierre Cau, Patrice Bourgeois, Vincent Bonniol, Nicolas Levy
-
Publication number: 20110114236Abstract: Road-going assembly consisting of a vehicle comprising a front axle and a rear axle, and of a set of tires which are mounted on their mounting rim in order to be fitted to the front axle and the rear axle of this vehicle, the tires of the rear axle having grooves the mean depths of which are at least equal to 3 mm and at most equal to 5 mm, the tires of the front axle having grooves the mean depths of which are greater than 5 mm, this road-going assembly having, at least in the case of the rear axle, static setups (camber, toe-in) of close to zero, that is to say a camber of each wheel-tire assembly on the said axle of between ?0.8 degrees and +0.8 degrees and a toe-in at each wheel of between ?0.15 degrees and +0.15 degrees, the static setups of the tires of one and the same axle being equal in terms of absolute value and symmetric with respect to a plane perpendicular to the road surface.Type: ApplicationFiled: March 17, 2009Publication date: May 19, 2011Applicants: Societe De Technologie Michelin, Michelin Recherche et Technique S.A.Inventors: Frédéric Perrin, Nicolas Levy
-
Publication number: 20110046091Abstract: This invention relates to a composition comprising an anti-HIV treatment and a treatment for side effects of said anti-HIV treatment in an HIV-infected patient. This invention is, for example, very useful in the treatment of side effects caused by certain anti-HIV treatments, for example premature aging and lipodystrophy, which can be caused by protease inhibitors or reverse transcriptase inhibitors. The composition of this invention includes at least one hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor, at least one farnesyl-pyrophosphate synthase inhibitor, and at least one anti-HIV agent. One of the processes for treating an HIV-infected patient includes, in any order, the following steps: (i) administration of a mixture including at least one hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and at least one farnesyl-pyrophosphate synthase inhibitor and (ii) administration of an anti-HIV agent, in which the administrations are concomitant, successive or alternative.Type: ApplicationFiled: December 31, 2008Publication date: February 24, 2011Applicant: UNIVERSITE DE LA MEDIERANNEE, AIX-MARSEILLE II JARDIN DU PHARO 58, BOULEVARD CHARLES LIVONInventors: Pierre Cau, Patrice Bourgeois, Vincent Bonniol, Nicolas Levy
-
Publication number: 20100120720Abstract: The invention relates to the use of a hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase inhibitor and of a farnesyl-pyrophosphate synthase inhibitor, or of one of their associated physiologically acceptable salts, in the preparation of a composition, particularly a pharmaceutical composition, for use in the treatment of human or animal, pathological or nonpathological situations related to the accumulation and/or the persistence of prenylated proteins in cells, such as during progeria (Hutchinson-Gilford syndrome), restrictive dermopathy or physiological aging.Type: ApplicationFiled: July 5, 2007Publication date: May 13, 2010Applicant: UNIVERSITE DE LA MEDITERRANEE AIX-MAR SEILLE IIInventors: Nicolas Levy, Pierre Cau, Carlos Lopez-Otin