Abstract: A process for preparing a compound of formula including oxidizing the triphenylmethane sulfone of formula (V) with a quinone chosen from 1,4-benzoquinone, 1,2-benzoquinone, a di(C1-C4)alkyl-1,4-benzoquinone, a di(C1-C4)alkyl-1,2-benzoquinone, a mono(C1-C4)alkyl-1,4-benzoquinone and a mono(C1-C4)alkyl-1,2-benzoquinone. A crystalline form of patent blue, sodium salt, can be achieved.

Abstract: A process for synthesizing a compound of formula (I) including: (a) condensing the benzaldehyde compound of formula (II) with the dialkylaniline of formula (III) to give the triphenylmethane of formula (IV); (b) treating the triphenylmethane of formula (IV) with sulfuric acid to form the triphenylmethane sulfone of the formula (V); and (c) oxidizing the triphenylmethane sulfone of formula (V) with a quinone. Such a process may be used to prepare patent blue.

Abstract: A gravel pack containing a substrate particle coated with an inducibly degradable and a porous particle having an internal interconnected porosity that is at least partially infused with an inducer material for dissolving of a layer of filter cake disposed between the gravel pack and a subterranean formation.

Abstract: A gravel pack containing a substrate particle coated with an inducibly degradable and a porous particle having an internal interconnected porosity that is at least partially infused with an inducer material for dissolving of a layer of filter cake disposed between the gravel pack and a subterranean formation.

Abstract: An aqueous composition, containing indocyanine green (a), and a compound (b) chosen from ascorbic acid, its salts, and mixtures thereof. A weight ratio of compound (b) to indocyanine green (a) ranges from 0.15 to 15 and a concentration of the indocyanine green (a) in the aqueous composition is between 0.1 and 30 mg/ml.

Abstract: A composition, containing 10 to 70% of indocyanine green, 0.1 to 15% of ethylenediaminetetraacetic acid (EDTA) and/or one or more salts thereof, 1 to 20% of histidine, and 20 to 80% of sodium chloride. The percentages are expressed by weight relative to a total weight of the indocyanine green, EDTA, histidine, and sodium chloride.

Abstract: A composition, containing indocyanine green (a), and histidine (b). A weight ratio of histidine (b)/indocyanine green (a) is greater than 0.05. A kit for preparing the composition, containing in separate compartments the indocyanine green (a), and an aqueous solution including the histidine (b). The composition is a medicament or a diagnostic agent.

Abstract: A process for synthesizing a compound of formula (I) including: (a) condensing the benzaldehyde compound of formula (II) with the dialkylaniline of formula (III) to give the triphenylmethane of formula (IV); (b) treating the triphenylmethane of formula (IV) with sulfuric acid to form the triphenylmethane sulfone of the formula (V); and (c) oxidizing the triphenylmethane sulfone of formula (V) with a quinone. Such a process may be used to prepare patent blue.

Abstract: A device that is able to generate a segmentation mask for an object in a digital image is provided. To do so, the device comprises a processing logic that is configured to use a previously trained auto-encoder to encode the image, and decode the image generating an additional alpha channel, which defines the segmentation mask.

Abstract: A gravel pack containing a substrate particle coated with an inducibly degradable and a porous particle having an internal interconnected porosity that is at least partially infused with an inducer material for dissolving of a layer of filter cake disposed between the gravel pack and a subterranean formation.

Abstract: A process for preparing a compound of formula including oxidizing the triphenylmethane sulfone of formula (V) with a quinone chosen from 1,4-benzoquinone, 1,2-benzoquinone, a di(C1-C4)alkyl-1,4-benzoquinone, a di(C1-C4)alkyl-1,2-benzoquinone, a mono(C1-C4)alkyl-1,4-benzoquinone and a mono(C1-C4)alkyl-1,2-benzoquinone. A crystalline form of patent blue, sodium salt, can be achieved.

Abstract: A gravel pack containing a substrate particle coated with an inducibly degradable and a porous particle having an internal interconnected porosity that is at least partially infused with an inducer material for dissolving of a layer of filter cake disposed between the gravel pack and a subterranean formation.

Abstract: Endometriosis is a chronic inflammatory systemic sex hormone-dependent gynecological disease, characterized by the presence and growth of endometrial tissue (glands and stroma) outside the uterine cavity, predominantly, but not exclusively, in the pelvic compartment. Here, the inventors show that the use of Neuropilin/VEGF binding inhibitors, so called, Neuropilin antagonist (NRPa), bring new perspective to treat and cure endometriosis in women suffering thereof. NRPa alone is efficient to inhibit primary endometrial cell proliferation and apoptosis/necrosis program cell death of targeted cells. The effective NRPa concentration needed is very low (NRPa-48 IC50=10?7M) and is dependent of the NRPa structure. Moreover, the association of NRPa with progestogen drug increases the anti-proliferative effect. Therefore, the present invention relates to the use of neuropilin antagonists for the treatment of endometriosis.

Abstract: Neuropilin-1 is henceforth a relevant target in cancer treatment, however way-of-action is remains partly elusive and the development of small inhibitory molecules is therefore required for its study. Here, the inventors report that two neuropilin small-sized antagonists (NRPa-47, NRPa-48), VEGF-A165/NRP-1 binding inhibitors, are able to decrease VEGF-Rs phosphorylation and to modulate their downstream cascades in triple negative breast cancer cell line (MDA-MB-231). In particular, the inventors showed for the first time, how NRPa may altered tumor cell signaling and contributed in the down-modulation of the cancer therapeutic key factor p38?-kinase phosphorylation. More importantly, the association of NRPa with a p38? inhibitor leads to additional and/or synergistic effect of these drugs (depending of the dose used) for significantly reducing breast cancer cell proliferation Thus, the efficient association of NRPa and p38?-kinase inhibitors are thus credible for the treatment of cancer.

Abstract: Method for producing a positive electrode for a solid-state lithium microbattery comprising the following successive steps: supplying of a substrate made of ceramic, glass or silicon, locally covered with a metal layer, depositing of a cathodic layer made of a positive electrode material, for example made of mixed lithium oxide, the cathodic layer having a thickness greater than 1 ?m, a first portion of the cathodic layer covering the substrate and a second portion of the cathodic layer covering the metal layer, intended to form the positive electrode, carrying out of a heat treatment at a temperature greater than or equal to 400° C., on the cathodic layer, in such a way as to crystallise the second portion of the cathodic layer in order to form a positive electrode, and in such a way as to delaminate the first portion of the cathodic layer.

Abstract: Process for preparing disodium 5,5?-indigosulfonate, the feedstock being indigo, this process including the following steps: i) the indigo is subjected to a sulfonation treatment resulting in a mixture that contains 5,5?-indigosulfonic acid, this process including: ii) a reduction treatment is applied to the mixture obtained in step i), and optionally a purification step, so as to obtain a composition including leuco-5,5?-indigosulfonic acid, iii) the leuco-5,5?-indigosulfonic acid is isolated from the composition resulting from step ii), iv) the leuco-5,5?-indigosulfonic acid resulting from step iii) is oxidized to give disodium 5,5?-indigosulfonate.

Abstract: Process for preparing disodium 5,5?-indigosulfonate, the feedstock being indigo, this process including the following steps: i) the indigo is subjected to a sulfonation treatment resulting in a mixture that contains 5,5?-indigosulfonic acid, this process including: ii) a reduction treatment is applied to the mixture obtained in step i), and optionally a purification step, so as to obtain a composition including leuco-5,5?-indigosulfonic acid, iii) the leuco-5,5?-indigosulfonic acid is isolated from the composition resulting from step ii), iv) the leuco-5,5?-indigosulfonic acid resulting from step iii) is oxidized to give disodium 5,5?-indigosulfonate.

Abstract: A gravel pack containing a substrate particle coated with an inducibly degradable and a porous particle having an internal interconnected porosity that is at least partially infused with an inducer material for dissolving of a layer of filter cake disposed between the gravel pack and a subterranean formation.

Abstract: Process for preparing disodium 5,5?-indigosulfonate, the feedstock being indigo, this process including the following steps: i) the indigo is subjected to a sulfonation treatment resulting in a mixture that contains 5,5?-indigosulfonic acid, this process including: ii) a reduction treatment is applied to the mixture obtained in step i), and optionally a purification step, so as to obtain a composition including leuco-5,5?-indigosulfonic acid, iii) the leuco-5,5?-indigosulfonic acid is isolated from the composition resulting from step ii), iv) the leuco-5,5?-indigosulfonic acid resulting from step iii) is oxidized to give disodium 5,5?-indigosulfonate.

Abstract: Method for producing a positive electrode for a solid-state lithium microbattery comprising the following successive steps: supplying of a substrate made of ceramic, glass or silicon, locally covered with a metal layer, depositing of a cathodic layer made of a positive electrode material, for example made of mixed lithium oxide, the cathodic layer having a thickness greater than 1 ?m, a first portion of the cathodic layer covering the substrate and a second portion of the cathodic layer covering the metal layer, intended to form the positive electrode, carrying out of a heat treatment at a temperature greater than or equal to 400° C., on the cathodic layer, in such a way as to crystallise the second portion of the cathodic layer in order to form a positive electrode, and in such a way as to delaminate the first portion of the cathodic layer.