Abstract: A process for analyzing a complex biological state of a biosystem from a sample of nucleic acids isolated from the biosystem including hybridization of the nucleic acids with probes fixed on a support, including: (a) contacting marked polynucleotide sequences prepared from nucleic acids of the sample with a first set of specific polynucleotide probes (E1) of a biological state and at least a second set of reference polynucleotide probes (E2) prepared from a molecule of reference nucleic acid for the biological state under conditions permitting the formation of hybridization products, and (b) detecting the hybridization products formed in step (a), wherein the first and second sets (E1, E2) are fixed on a support and the first set of probes includes n groups of probes, each group being characteristic of a different genetic profile that influences the biological state and can therefore alter it, and each group being assembled on the support in separate positions that are also separated from that (those) of the