Patents by Inventor Nicolas Moniaux

Nicolas Moniaux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYPEPTIDE FOR USE IN THE PROTECTION OF OXYGEN SENSITIVE GRAM-POSITIVE BACTERIA
    Publication number: 20240197821
    Abstract: The present disclosure concerns a Reg3? polypeptide (also known as Hepatocarcinoma-Intestine-Pancreas/Pancreatitis Associated Protein (HIP/PAP)) for protecting oxygen sensitive gram-positive bacteria, compositions including the polypeptide, and their use. The disclosure shows that increasing concentration of the hReg3? lectin into the gastrointestinal tract (GIT) lumen of hReg3?-transgenic mice induced significant changes in composition of gut microbiota, and dramatically improved host resistance to intestinal inflammation.
    Type: Application
    Filed: October 26, 2023
    Publication date: June 20, 2024
    Inventors: Joël DORE, Jamila FAIVRE, Nicolas MONIAUX, Christian BRECHOT, Marion DARNAUD
  • Polypeptide for use in the protection of oxygen sensitive gram-positive bacteria
    Patent number: 11484569
    Abstract: The invention concerns a Reg3? polypeptide (also known as Hepatocarcinoma-Intestine-Pancreas/Pancreatitis Associated Protein (HIP/PAP)) for use in the protection of oxygen sensitive gram-positive bacteria, compositions comprising the polypeptide and their use. The inventors have shown that an increase in the concentration of the h Reg3? lectin into the gastrointestinal tract (GIT) lumen of hReg3?-transgenic mice induced significant changes in the composition of the gut microbiota, and dramatically improved host resistance to intestinal inflammation. hReg3? exerted a potent antioxidant activity on intestinal epithelial cells during colitis, and in particular the ROS scavenging activity, in particular, by promoting the survival of highly oxygen sensitive bacteria. Inventors also showed that h Reg3?-transgenic mice resist better to DSS-induced colitis after antibiotherapy.
    Type: Grant
    Filed: July 13, 2018
    Date of Patent: November 1, 2022
    Assignees: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM), ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS, INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA), UNIVERSITÉ PARIS-SUD
    Inventors: Joël Dore, Jamila Faivre, Nicolas Moniaux, Christian Brechot, Marion Darnaud
  • POLYPEPTIDE FOR USE IN THE PROTECTION OF OXYGEN SENSITIVE GRAM-POSITIVE BACTERIA
    Publication number: 20220233639
    Abstract: The invention concerns a Reg3? polypeptide (also known as Hepatocarcinoma-Intestine-Pancreas/Pancreatitis Associated Protein (HIP/PAP)) for protecting oxygen sensitive gram-positive bacteria, compositions comprising the polypeptide, and their use. The inventors showed that increasing concentration of the hReg3? lectin into the gastrointestinal tract (GIT) lumen of hReg3?-transgenic mice induced significant changes in composition of gut microbiota, and dramatically improved host resistance to intestinal inflammation. hReg3? exerted a potent antioxidant activity on intestinal epithelial cells during colitis, and the ROS scavenging activity, by promoting the survival of highly oxygen sensitive bacteria. Inventors also showed that hReg3?-transgenic mice were better able to resist DSS-induced colitis after antibiotherapy.
    Type: Application
    Filed: January 12, 2022
    Publication date: July 28, 2022
    Inventors: Joël DORE, Jamila FAIVRE, Nicolas MONIAUX, Christian BRECHOT, Marion DARNAUD
  • POLYPEPTIDE FOR USE IN THE PROTECTION OF OXYGEN SENSITIVE GRAM-POSITIVE BACTERIA
    Publication number: 20210093694
    Abstract: The invention concerns a Reg3? polypeptide (also known as Hepatocarcinoma-Intestine-Pancreas/Pancreatitis Associated Protein (HIP/PAP)) for use in the protection of oxygen sensitive gram-positive bacteria, compositions comprising the polypeptide and their use. The inventors have shown that an increase in the concentration of the h Reg3? lectin into the gastrointestinal tract (GIT) lumen of hReg3?-transgenic mice induced significant changes in the composition of the gut microbiota, and dramatically improved host resistance to intestinal inflammation. hReg3? exerted a potent antioxidant activity on intestinal epithelial cells during colitis, and in particular the ROS scavenging activity, in particular, by promoting the survival of highly oxygen sensitive bacteria. Inventors also showed that h Reg3?-transgenic mice resist better to DSS-induced colitis after antibiotherapy.
    Type: Application
    Filed: July 13, 2018
    Publication date: April 1, 2021
    Inventors: Joël DORE, Jamila FAIVRE, Nicolas MONIAUX, Christian BRECHOT, Marion DARNAUD
  • Compositions and methods for inhibiting pancreatic cancer metastasis
    Patent number: 7105657
    Abstract: Methods are provided for the inhibition of metastasis of cancer cells expressing MUC4, metastatic pancreatic cancer cells.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: September 12, 2006
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Surinder K. Batra, Ajay P. Singh, Nicolas Moniaux
  • MUC17 encoding nucleic acid sequences, polypeptides, antibodies and methods of use thereof
    Patent number: 7078188
    Abstract: Disclosed herein are human MUC17-encoding nucleotide sequences, proteins, antibodies, and methods for use thereof.
    Type: Grant
    Filed: November 10, 2003
    Date of Patent: July 18, 2006
    Assignee: Board of Regents of the University of Nebraska
    Inventors: Surinder Batra, Nicolas Moniaux
  • MUC17 encoding nucleic acid sequences, polypeptides, antibodies and methods of use thereof
    Publication number: 20050100925
    Abstract: Disclosed herein are human MUC17-encoding nucleotide sequences, proteins, antibodies, and methods for use thereof.
    Type: Application
    Filed: November 10, 2003
    Publication date: May 12, 2005
    Inventors: Surinder Batra, Nicolas Moniaux
  • Compositions and methods for inhibiting pancreatic cancer metastasis
    Publication number: 20040091869
    Abstract: Methods are provided for the inhibition of metastasis of cancer cells expressing MUC4, metastatic pancreatic cancer cells.
    Type: Application
    Filed: November 8, 2002
    Publication date: May 13, 2004
    Inventors: Surinder K. Batra, Ajay P. Singh, Nicolas Moniaux