Patents by Inventor Nicolas RASCHE

Nicolas RASCHE has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMBINATION THERAPY UTILIZING DNA ALKYLATING AGENTS AND ATR INHIBITORS
    Publication number: 20210369705
    Abstract: The present invention relates to synergistic combinations of DNA-alkylating ADCs and ATR inhibitors.
    Type: Application
    Filed: October 14, 2019
    Publication date: December 2, 2021
    Applicant: Merck Patent GmbH
    Inventors: Carl DEUTSCH, Birgit PIATER, Nicolas RASCHE, Heike DAHMEN, Frank ZENKE, Astrid ZIMMERMANN, Marcel RIEKER
  • CYSTEINE ENGINEERED ANTIGEN-BINDING MOLECULES
    Publication number: 20200277399
    Abstract: A specific antigen-binding member (ABM) comprising a specific antigen-binding moiety and an antibody Fc region comprising a CH2 domain, which is engineered for a cysteine substitution at position 108 and/or 113, wherein numbering is according to the IMGT, and wherein the antibody Fc region does not comprise an antigen-binding CH3 domain; and an ABM conjugate (ABMC) comprising the ABM and at least one heterologous molecule covalently conjugated to one or both of the cysteines at positions 108 and 113 of the CH2 domain.
    Type: Application
    Filed: October 3, 2018
    Publication date: September 3, 2020
    Applicant: MERCK PATENT GMBH
    Inventors: Gordana WOZNIAK-KNOPP, Florian RÜKER, Gerhard STADLMAYR, Jakub RYBKA, Nicolas RASCHE, Stephan DICKGIESSER