Patents by Inventor Nicolas Ugolin

Nicolas Ugolin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10829837
    Abstract: A microwave thermosolar method and device used in a tubular reactor (110) includes a conveyor for substrates defined as materials thus conveyed. According to this method, a step is provided for circulating an electric current in the conveyor in order to produce heat in this conveyor by Joule effect and optionally to cause, in the substrates, at least some of the following: curing, pyrolyses, gasifications, fusions and chemical reactions including oxidation-reduction reactions, under the action of the electric current.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: November 10, 2020
    Inventor: Nicolas Ugolin
  • Publication number: 20160348211
    Abstract: A microwave thermosolar method and device used in a tubular reactor (110) includes a conveyor for substrates defined as materials thus conveyed. According to this method, a step is provided for circulating an electric current in the conveyor in order to produce heat in this conveyor by Joule effect and optionally to cause, in the substrates, at least some of the following: curing, pyrolyses, gasifications, fusions and chemical reactions including oxidation-reduction reactions, under the action of the electric current.
    Type: Application
    Filed: February 6, 2015
    Publication date: December 1, 2016
    Inventor: Nicolas UGOLIN
  • Patent number: 9400252
    Abstract: A process, for the quantitative analysis by optical emission spectroscopy of a plasma induced by a laser beam of at least one target included in a biochip, involves the use of an adjuvant allowing the formation of a dry matrix capable of being ablated simultaneously with the at least one target, the dry matrix being configured to improve the analytical properties of plasma, the adjuvant having an emission spectrum whose lines have wavelengths distinct from the wavelengths of the spectral lines used for the quantitative analysis of said at least one target.
    Type: Grant
    Filed: September 13, 2013
    Date of Patent: July 26, 2016
    Assignee: COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES
    Inventors: Nadine Coulon, Nicolas Ugolin, Caroline Falck, Emilie Lefevre, Sylvie Chevillard
  • Publication number: 20160202234
    Abstract: The invention relates to a method for evaluating, via biodosimetry, the irradiation dose received by a person subjected to ionizing radiation. Said method comprises: a) sampling, in at least one area of the body of the person, the follicles or bulbs of head and/or body hair of the person; b) extracting proteins from cells of said sampled hair bulbs or follicles, wherein said proteins, including proteins from the ATM system, are subjected to phosphorylation and/or acetylation induced by ionizing radiation; and c) analyzing at least two types of extracted proteins and interpreting the analysis results in order to determine the irradiation dose in the or each sampling area.
    Type: Application
    Filed: May 15, 2014
    Publication date: July 14, 2016
    Applicant: ACUBENS
    Inventors: Ivana JUKIC, Amélie SCHELLENBERG, Jozo DELIC, Arnaud TUPINIER, Vincent PAGET, Yohann FEDOR, Luc MORAT, Nicolas UGOLIN, Caroline FLACK, Sylvie CHEVILLARD, Emilie LEFEVRE
  • Publication number: 20150233837
    Abstract: A process, for the quantitative analysis by optical emission spectroscopy of a plasma induced by a laser beam of at least one target included in a biochip, involves the use of an adjuvant allowing the formation of a dry matrix capable of being ablated simultaneously with the at least one target, the dry matrix being configured to improve the analytical properties of plasma, the adjuvant having an emission spectrum whose lines have wavelengths distinct from the wavelengths of the spectral lines used for the quantitative analysis of said at least one target.
    Type: Application
    Filed: September 13, 2013
    Publication date: August 20, 2015
    Inventors: Nadine Coulon, Nicolas Ugolin, Caroline Falck, Emilie Lefevre, Sylvie Chevillard
  • Patent number: 8906203
    Abstract: A system enables the use of solar heat energy together with electromagnetic energy and optionally energy produced during fermentation of organic products to produce fresh water from salt water, wastewater and water vapor contained in the atmosphere. The resulting fresh water can optionally be rendered drinkable by adding mineral salts at the desired concentration. A method and reactors combine electromagnetic and solar heating steps and optionally heat exchanges with a hot gas originating from combustion, to evaporate droplets of a spray produced from salt water or wastewater. The vapor obtained is separated from the salt particles or agglomerated impurities during evaporation using a cyclone system. The vapor can then be transported over a large distance before being condensed by bearings, in order to separate the water from any additives or impurities that may be present. Additives can be used to lower the vapor pressure of the liquid water and to facilitate droplet fractionation.
    Type: Grant
    Filed: August 20, 2009
    Date of Patent: December 9, 2014
    Inventor: Nicolas Ugolin
  • Patent number: 8675192
    Abstract: The present invention relates to a device and method for the high speed quantitative measurement of biomolecular targets on the surface or in the body of a planar medium for biological analysis.
    Type: Grant
    Filed: March 20, 2009
    Date of Patent: March 18, 2014
    Assignee: Commissariat a l'Energie Atomique et Aux Energies Alternatives
    Inventors: Nicolas Ugolin, Denis Menut, Julien Le Meur, Nadine Coulon, Sylvie Chevillard, Emilie Bosc, Jean-Marc Joseph Desaulniers
  • Patent number: 8486866
    Abstract: The present invention relates in particular to a method for the quantitative measurement of biomolecular targets that have been deposited on a biochip (1) of the type with a matrix of probes hybridized by the targets, the matrix comprising a multitude of measurement points (2) each comprising a plurality of probes, characterized in that it comprises the following steps: a) at least one laser beam (18) is focused onto each measurement point, in order to extract therefrom a hot confined plasma comprising a chemical element to be quantified that is present in the targets and optionally in the probes; b) the light emission lines from the plasma are detected and analysed for each measurement point, by measuring the respective intensities of these lines; and then c) the concentration in each measurement point of the element or of a group incorporating it within the targets is determined via a prior calibration of the lines establishing a correlation between the intensities of the lines specific to the element to be
    Type: Grant
    Filed: September 14, 2007
    Date of Patent: July 16, 2013
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Nicolas Ugolin, Denis Menut, Julien Le Meur, Pascal Wodling, Sylvie Chevillard
  • Publication number: 20130101665
    Abstract: Novel chimeric molecules, termed “half-antibodies”, which are capable of self-assembling to form an epitope recognition site. Using these half-antibodies or a vesicle, a viral particle, a composition or a kit thereof, for therapeutic applications, such as the prevention or treatment of cancers, genetic diseases, infectious diseases, and for in vitro diagnostic applications and detecting biological molecules. The half-antibodies include at least two chimeric molecules A and B, each has a polypeptide domain characteristic of a variable domain of a heavy chain or of a light chain of an antibody, and a nucleotide domain, the nucleotide domain of A and that of B being capable of pairing into a double stranded structure. Biologically active nucleic sequences can be grafted onto these chimeric molecules to prevent the expression of target genes in the interior of a human or non-human mammalian cell.
    Type: Application
    Filed: April 8, 2011
    Publication date: April 25, 2013
    Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Nicolas Ugolin, Caroline Falck, Emilie Lefevre, Sylvie Chevillard, Carine Tisne-Vicrobeck
  • Patent number: 8388706
    Abstract: A system uses thermal solar energy coupled with microwaves and plasma for producing carbon monoxide (CO) and dihydrogen (H2) from carbonated compounds (biomass, domestic waste, sludge from waste water, fossil coal), wherein the obtained gaseous mixture yields, amongst others, hydrocarbon fuels (olefins, paraffin), esters, and alcohols via a Fischer-Tropsch synthesis. In a first step the carbonated compounds are roasted and pyrolized to produce char and dry coal, and a mixture of superheated gases containing CO2, steam, tars and non-condensable volatile materials. The method includes in a second step, and from the pyrolyis products (char or coal, gas mixture), generating a syngas substantially containing a mixture of carbon monoxide and dihydrogen, the mixture being used in Fischer-Tropsch synthesis units. After the Fischer-Tropsch step, the synthesis products are separated in a distillation column after heating in solar furnaces of mixed furnaces (solar/microwave).
    Type: Grant
    Filed: November 14, 2008
    Date of Patent: March 5, 2013
    Inventor: Nicolas Ugolin
  • Publication number: 20130012400
    Abstract: The invention relates to a method of analysing molecular targets contained in a complex mixture, comprising the following steps consisting in: a) bringing the mixture of molecular targets to be analysed into contact with an array of different types of primary probes, whereby each type of primary probe forming the array can bind specifically to a type of target selected from among the molecular targets, under conditions that enable specific binding between the molecular targets and the primary probes; b) optionally eliminating the primary probes that are not bound specifically to a molecular target; c) separating the molecular targets and the primary probes which are bound specifically in a probe/target complex, such as to recover the array of primary probes representing a fingerprint of the molecular targets to be analysed; and d) quantitatively analysing the primary probes eluted in step c.
    Type: Application
    Filed: May 7, 2012
    Publication date: January 10, 2013
    Inventors: Nicolas Ugolin, Sylvie Chevillard, Alexadre Coutant, Jerome Lebeau
  • Patent number: 8241893
    Abstract: The invention relates to a method of analysing molecular targets contained in a complex mixture, comprising the following steps consisting in: a) bringing the mixture of molecular targets to be analysed into contact with an array of different types of primary probes, whereby each type of primary probe forming the array can bind specifically to a type of target selected from among the molecular targets, under conditions that enable specific binding between the molecular targets and the primary probes; b) optionally eliminating the primary probes that are not bound specifically to a molecular target; c) separating the molecular targets and the primary probes which are bound specifically in a probe/target complex, such as to recover the array of primary probes representing a fingerprint of the molecular targets to be analysed; and d) quantitatively analysing the primary probes eluted in step c.
    Type: Grant
    Filed: August 24, 2007
    Date of Patent: August 14, 2012
    Assignee: Commissariat a l 'Energie Atomique
    Inventors: Nicolas Ugolin, Sylvie Chevillard, Alexadre Coutant, Jerome LeBeau
  • Patent number: 8211693
    Abstract: The invention relates to a device for separating and/analyzing several molecular targets dissolved in a complex mixture which is characterized in that it comprises a) a matrix of micro-columns, wherein each micro-column (2) comprises an immobilized molecular probe for retaining a specific molecular target contained in the complex mixture by specific probe/target linkage, b) a first capillary network (3) for circulating the complex mixture introduced into the inventive device towards each micro-column of the matrix defined in a), c) a second capillary network (4) for circulating, after elution, the molecular targets retained on the micro-columns towards a sensor (5) for carrying out the recovery and/or analysis thereof, and d) if necessary, a sensor (5), preferably in the form of a mass spectrometer, for carrying out the recovery and/or analysis of different molecular targets.
    Type: Grant
    Filed: February 4, 2010
    Date of Patent: July 3, 2012
    Assignee: Commissariat a l'Energie Atomique
    Inventors: Nicolas Ugolin, Sylvie Chevillard, Catherine Ory, Jerome Lebeau
  • Publication number: 20110174605
    Abstract: A system enables the use of solar heat energy together with electromagnetic energy and optionally energy produced during fermentation of organic products to produce fresh water from salt water, wastewater and water vapor contained in the atmosphere. The resulting fresh water can optionally be rendered drinkable by adding mineral salts at the desired concentration. A method and reactors combine electromagnetic and solar heating steps and optionally heat exchanges with a hot gas originating from combustion, to evaporate droplets of a spray produced from salt water or wastewater. The vapor obtained is separated from the salt particles or agglomerated impurities during evaporation using a cyclone system. The vapor can then be transported over a large distance before being condensed by bearings, in order to separate the water from any additives or impurities that may be present. Additives can be used to lower the vapor pressure of the liquid water and to facilitate droplet fractionation.
    Type: Application
    Filed: August 20, 2009
    Publication date: July 21, 2011
    Inventor: Nicolas Ugolin
  • Publication number: 20110109904
    Abstract: The present invention relates to a device and method for the high speed quantitative measurement of biomolecular targets on the surface or in the body of a planar medium for biological analysis.
    Type: Application
    Filed: March 20, 2009
    Publication date: May 12, 2011
    Inventors: Nicolas Ugolin, Denis Menut, Julien Le Meur, Nadine Coulon, Sylvie Chevillard, Emilie Bosc, Jean-Marc-Joseph Desaulniers
  • Publication number: 20100258429
    Abstract: A system uses thermal solar energy coupled with microwaves and plasma for producing carbon monoxide (CO) and dihydrogen (H2) from carbonated compounds (biomass, domestic waste, sludge from waste water, fossil coal), wherein the obtained gaseous mixture yields, amongst others, hydrocarbon fuels (olefins, paraffin), esters, and alcohols via a Fischer-Tropsch synthesis. In a first step the carbonated compounds are roasted and pyrolized to produce char and dry coal, and a mixture of superheated gases containing CO2, steam, tars and non-condensable volatile materials. The method includes in a second step, and from the pyrolyis products (char or coal, gas mixture), generating a syngas substantially containing a mixture of carbon monoxide and dihydrogen, the mixture being used in Fischer-Tropsch synthesis units. After the Fischer-Tropsch step, the synthesis products are separated in a distillation column after heating in solar furnaces of mixed furnaces (solar/microwave).
    Type: Application
    Filed: November 14, 2008
    Publication date: October 14, 2010
    Inventor: Nicolas Ugolin
  • Publication number: 20100203540
    Abstract: The invention relates to a device for separating and/analyzing several molecular targets dissolved in a complex mixture which is characterized in that it comprises a) a matrix of micro-columns, wherein each micro-column (2) comprises an immobilized molecular probe for retaining a specific molecular target contained in the complex mixture by specific probe/target linkage, b) a first capillary network (3) for circulating the complex mixture introduced into the inventive device towards each micro-column of the matrix defined in a), c) a second capillary network (4) for circulating, after elution, the molecular targets retained on the micro-columns towards a sensor (5) for carrying out the recovery and/or analysis thereof, and d) if necessary, a sensor (5), preferably in the form of a mass spectrometer, for carrying out the recovery and/or analysis of different molecular targets.
    Type: Application
    Filed: February 4, 2010
    Publication date: August 12, 2010
    Inventors: Nicolas UGOLIN, Sylvie CHEVILLARD, Catherine ORY, Jerome LEBEAU
  • Patent number: 7687257
    Abstract: The invention relates to a device for separating and/analyzing several molecular targets dissolved in a complex mixture which is characterized in that it comprises a) a matrix of micro-columns, wherein each micro-column (2) comprises an immobilized molecular probe for retaining a specific molecular target contained in the complex mixture by specific probe/target linkage, b) a first capillary network (3) for circulating the complex mixture introduced into the inventive device towards each micro-column of the matrix defined in a), c) a second capillary network (4) for circulating, after elution, the molecular targets retained on the micro-columns towards a sensor (5) for carrying out the recovery and/or analysis thereof, and d) if necessary, a sensor (5), preferably in the form of a mass spectrometer, for carrying out the recovery and/or analysis of different molecular targets.
    Type: Grant
    Filed: March 23, 2006
    Date of Patent: March 30, 2010
    Assignee: Commissariat a'Lenergie Atomique
    Inventors: Nicolas Ugolin, Sylvie Chevillard, Catherine Ory, Jerome Lebeau
  • Publication number: 20100022400
    Abstract: The present invention relates in particular to a method for the quantitative measurement of biomolecular targets that have been deposited on a biochip (1) of the type with a matrix of probes hybridized by the targets, the matrix comprising a multitude of measurement points (2) each comprising a plurality of probes, characterized in that it comprises the following steps: a) at least one laser beam (18) is focused onto each measurement point, in order to extract therefrom a hot confined plasma comprising a chemical element to be quantified that is present in the targets and optionally in the probes; b) the light emission lines from the plasma are detected and analysed for each measurement point, by measuring the respective intensities of these lines; and then c) the concentration in each measurement point of the element or of a group incorporating it within the targets is determined via a prior calibration of the lines establishing a correlation between the intensities of the lines specific to the element to be
    Type: Application
    Filed: September 14, 2007
    Publication date: January 28, 2010
    Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE
    Inventors: Nicolas Ugolin, Denis Menut, Julien Le Meur, Pascal Wodling, Sylvie Chevillard
  • Publication number: 20090054264
    Abstract: The invention relates to a method of fabricating an array of capillaries of a chip, the method comprising the steps consisting in depositing at least one layer of a meltable or polymerizable construction material on a support plate, focusing and moving a laser beam on and over said layer respectively to melt or polymerize the material so as to form the side walls of the capillaries, and then fastening a cover plate on the side walls of the capillaries. The invention also provides a chip including an array of capillaries in which chemical or biological molecules are fixed, and a chip including an array of chromatography and/or electrophoresis capillaries.
    Type: Application
    Filed: February 26, 2007
    Publication date: February 26, 2009
    Applicant: COMMISSARIAT A L'ENERGIE ATOMIQUE
    Inventors: Nicolas Ugolin, Pascal Wodling, Julien Le Meur, Pierre-Yves Tro, Sylvie Chevillard