Patents by Inventor Nicole A. M. Dorme

Nicole A. M. Dorme has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5237066
    Abstract: Enantiomer of absolute configuration S of formula: ##STR1## where: X=O or S; andAr denotes a:* phenyl ring substituted with one, two or three C.sub.1 -C.sub.4 alkoxy groups;* phenyl ring substituted at the 2-position with a OCH.sub.3 group and at the 5-position with a halogen atom or a lower alkylcarbonyl group;* phenyl ring substituted at the 2-position with OCH.sub.3, at the 4-position with NH.sub.2 or alkylcarbonyl-NH and at the 5-position with a halogen;* 3-fluoro-2-methoxyphenyl group;* 5-pyrimidinyl group substituted at the 2-position with NH.sub.2 and in the 4-position with alkoxy or phenyloxy.These compounds are useful as medicinal products having activity in respect of gastric movements and antiemetic activity.
    Type: Grant
    Filed: September 17, 1991
    Date of Patent: August 17, 1993
    Assignee: Delande S.A.
    Inventors: Nicole A. M. Dorme, Alain J. L. Renaud, Michel Langlois
  • Patent number: 4657911
    Abstract: New derivatives of 3-amino quinuclidine of formula: ##STR1## in which X=sulfur or oxygen; R=H, lower alkyl or benzyl; and Ar=substituted phenyl or substituted pyrimidinyl.These new derivatives have utility in therapeutics as accelerators of the gastro-intestinal motor function and as medicament potentiators.
    Type: Grant
    Filed: June 29, 1983
    Date of Patent: April 14, 1987
    Assignee: Delalande S.A.
    Inventors: Thierry F. Imbert, Nicole A. M. Dorme, Michel Langlois
  • Patent number: 4104384
    Abstract: Compounds of the formula ##STR1## where Ar is phenyl, substituted phenyl, .alpha.-furyl or .alpha.-thienyl, andR is NH.sub.2, NHR.sup.1 wherein R.sup.1 is alkyl or cycloalkyl, or NR.sub.1 R.sub.2 whereinR.sub.1 and R.sub.2 are alkyl or --N.sub.1 R.sub.1 R.sub.2 is piperidino, pyrrolidino, morpholino or hexamethyleneimino. The compounds are prepared by reacting the corresponding Ar-substituted chloromethylated benzimadazole with the corresponding R-substituted piperazine. The compounds possess gastric antisecretory, anti-ulcerous, spasmolytic, anti-cholinergic, anti-bronchoconstrictive, analgesic, anti-inflammatory, anti-hypertensive and diuretic properties.
    Type: Grant
    Filed: November 28, 1977
    Date of Patent: August 1, 1978
    Assignee: Delalande S.A.
    Inventors: Claude P. Fauran, Michel J. Turin, Thierry F. Imbert, Guy M. Raynaud, Nicole A. M. Dorme
  • Patent number: 4072682
    Abstract: Compounds of the formula ##STR1## where Ar is phenyl, substituted phenyl, .alpha.-furyl or .alpha.-thienyl, andR is NH.sub.2, NHR.sup.1 wherein R.sup.1 is alkyl or cycloalkyl, or NR.sub.1 R.sub.2wherein R.sub.1 and R.sub.2 are alkyl or --N.sub.1 R.sub.1 R.sub.2 is piperidino, pyrrolidino, morpholino or hexamethyleneimino. The compounds are prepared by reacting the corresponding Ar-substituted chloromethylated benzimidazole with the corresponding R-substituted piperazine. The compounds possess gastric antisecretory, anti-ulcerous, spasmolytic, anti-cholinergic, anti-bronchoconstrictive, analgesic, anti-inflammatory, anti-hypertensive and diuretic properties.
    Type: Grant
    Filed: December 22, 1975
    Date of Patent: February 7, 1978
    Assignee: Delalande S.A.
    Inventors: Claude P. Fauran, Michel J. Turin, Thierry F. Imbert, Guy M. Raynaud, Nicole A. M. Dorme
  • Patent number: 4031089
    Abstract: Compounds of the formula ##STR1## wherein R is alkyl of 1-4 carbon atoms, phenyl, or phenyl substituted by one or more halogen or trifluoromethyl, and Z is ##STR2## wherein R.sub.1 is hydrogen, alkyl of 1-4C, 2,2-dimethyldioxolan-4-yl methyl, or 2,3-dihydroxy prop-1-yl, R.sub.2 is ##STR3## wherein ##STR4## is morpholino, pyrrolidino, piperidino or hexamethyleneimino, and n is an integer from 4 to 7.The compounds are prepared by reacting R-substituted 4-chloro-2-methyl furo (2,3d) pyrimidine with HZ. The compounds possess antiulcerous, antibronchoconstrictive and anticholinergic, analgesic, antihistamine, diuretic, cardiovascular analeptic, antiinflammatory and hypertensive properties.
    Type: Grant
    Filed: August 18, 1976
    Date of Patent: June 21, 1977
    Assignee: Delalande S.A.
    Inventors: Claude P. Fauran, Guy R. Bourgery, Guy M. Raynaud, Nicole A. M. Dorme
  • Patent number: 4007187
    Abstract: Compounds of the formula ##STR1## wherein R is alkyl of 1-4 carbon atoms, phenyl, or phenyl substituted by one or more halogen or trifluoromethyl, and Z is ##STR2## wherein R.sub.1 is hydrogen, alkyl of 1-4C, 2,2-dimethyldioxolan-4-yl methyl, or 2,3-dihydroxy prop-1-yl, R.sub.2 is ##STR3## wherein ##STR4## is morpholino, pyrrolidino, piperidino or hexamethyleneimino, and n is an integer from 4 to 7. The compounds are prepared by reacting R-substituted 4-chloro-2-methyl furo (2,3d) pyrimidine with HZ. The compounds possess antiulcerous, antibronchoconstrictive and anticholinergic, analgesic, antihistamine, diuretic, cardiovascular analeptic, antiinflammatory and hypertensive properties.
    Type: Grant
    Filed: September 17, 1974
    Date of Patent: February 8, 1977
    Assignee: Delalande S.A.
    Inventors: Claude P. Fauran, Guy R. Bourgery, Guy M. Raynaud, Nicole A. M. Dorme
  • Patent number: 3962256
    Abstract: Compounds having the formula ##EQU1## WHEREIN Ar is phenyl optionally substituted by one or more halogens, alkyl having 1 to 4 carbons or alkoxy containing up to 4 carbons, and R.sub.1 and R.sub.2 each is alkyl having one to 4 carbons or ##EQU2## is piperidino, pyrrolidino, morpholino and hexamethyleneimino. The compounds are prepared by reacting the corresponding 2-chloromethyl benzimidazole with ##EQU3## The compounds possess analgesic, antihypertensive, gastric antisecretory, antiinflammatory, antibronchoconstrictive, anticholinergic, spasmolytic, sedative, antiulcerous, vasodilatatory, central nervous system stimulant, antiarythmic, diuretic and antihistaminic properties.
    Type: Grant
    Filed: June 20, 1974
    Date of Patent: June 8, 1976
    Assignee: Delalande S.A.
    Inventors: Claude P. Fauran, Jeannine A. Eberle, Guy M. Raynaud, Nicole A. M. Dorme