Abstract: The disclosure is related to vancomycin resistance and, in particular, to compositions comprising vancomycin for use in inhibiting growth of a vancomycin-resistant microorganism or for use in treating a subject infected with a vancomycin-resistant pathogen. In one aspect, the disclosure provides a composition comprising vancomycin and d-alanine. The disclosure also provides means and methods for treating a subject infected with a vancomycin-resistant microorganism. The disclosure further provides bacteria with a functionally deactivated gene in the vancomycin-resistance cluster.