Patents by Inventor Nicole Anne Datson

Nicole Anne Datson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20230348909
    Abstract: Provided herein are antisense oligonucleotides (AONs) that induce skipping of exon 51 of human dystrophin pre-mRNA, and pharmaceutically acceptable derivatives thereof. Also provided are pharmaceutical compositions containing the AONs and methods of using the AONs and compositions for treating a subject with Duchenne muscular dystrophy.
    Type: Application
    Filed: March 29, 2023
    Publication date: November 2, 2023
    Inventors: Steven Michael Froelich, Josh Christopher Woloszynek, Jenna-Marie Magat, Judith Christina Theodora van Deutekom, Peter Christian de Visser, Nicole Anne Datson
  • Patent number: 5928867
    Abstract: Method of isolating exonic gene segments of a eukaryotic gene by preparing a loaded exon trapping vector, bringing the loaded exon trapping vector in an environment in which transcription of DNA to RNA and RNA processing can occur, isolating processed RNA which includes exonic gene segments of the eukaryotic gene and, optionally, preparing a DNA copy of the isolated processed RNA. The loaded exon trapping vector comprises a large-insert DNA vector containing a segmented donor gene construct and, inserted in or close to said segmented donor gene construct, a target DNA fragment of at least 10 kb of eukaryotic genomic DNA. Use of vectors containing large genomic inserts allows to isolate exonic gene segments present in the correct transcriptional orientation as a complete set, without need for reordering individually isolated exons and verifying their continuity from isolated cDNAs.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: July 27, 1999
    Assignee: Rijksuniversiteit Leiden
    Inventors: Johan Theodorus den Dunnen, Johanes Gregorius Dauwerse, Nicole Anne Datson, Garrit Jan Boudewijn van Ommen