Patents by Inventor Nicole Billings

Nicole Billings has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PLATFORM FOR EARLY DETECTION OF PATHOGEN INFECTION
    Publication number: 20200363398
    Abstract: A method for identifying an interaction between a pathogen and a biological agent includes providing a platform for supporting cell growth, seeding different interaction sites on the platform with different biological agents, perfusing the platform with a fluid that carries substances for promoting growth and maintenance of the cells, exposing all of the interaction sites to a solution containing viruses, and detecting evidence indicative of the interaction, the evidence comprising evidence indicative of a change in structure or composition of a medium at the interaction site. The biological agent includes cells alone or cells with another substance.
    Type: Application
    Filed: January 9, 2019
    Publication date: November 19, 2020
    Inventors: Else M. Vedula, Kirsty A. McFarland, Amanda Nicole Billings-Siuti, Andrew P. Magyar
  • Bacteriophage engineering methods
    Patent number: 10815535
    Abstract: The present disclosure provides methods and kits for generating recombinant bacteriophage genomes.
    Type: Grant
    Filed: March 27, 2017
    Date of Patent: October 27, 2020
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Jason Holder, Connor McBrine, Sarah Gruszka, Miles Rogers, Nicole Billings
  • MODIFIED TEMPLATE-INDEPENDENT DNA POLYMERASE
    Publication number: 20200263152
    Abstract: Described herein are genetically engineered template-independent DNA polymerases, specifically terminal deoxynucleotidyl transferases, and methods of using these polymerases to control DNA synthesis by adding a single nucleotide (mononucleotide) at a time to the 3? end of a growing single-stranded DNA polynucleotide.
    Type: Application
    Filed: May 22, 2018
    Publication date: August 20, 2020
    Inventors: Andrew P. Magyar, Peter Cavanagh, Miles Rogers, Kirsty A. McFarland, Melissa M. Sprachman, Amanda Nicole Billings-Siuti, Nicole E. Raustad
  • Bacteriophage recombination followed by blockage of non-recombinant bacteriophage replication
    Patent number: 10494638
    Abstract: The present disclosure provides methods and kits for generating recombinant bacteriophage genomes. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a bacteriophage DNA genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.
    Type: Grant
    Filed: February 9, 2018
    Date of Patent: December 3, 2019
    Assignee: The Charles Stark Draper Laboratory, Inc.
    Inventors: Jason Holder, Connor McBrine, Miles Rogers, Nicole Billings, Sarah Gruska, Lucas Tilley
  • BACTERIOPHAGE RECOMBINATION FOLLOWED BY BLOCKAGE OF NON-RECOMBINANT BACTERIOPHAGE REPLICATION
    Publication number: 20180223291
    Abstract: The present disclosure provides methods and kits for generating recombinant bacteriophage genomes. Specifically, the present technology provides methods of integrating a heterologous nucleic acid sequence into a bacteriophage DNA genome, and isolating recombinant bacteriophages that express the heterologous nucleic acid sequence.
    Type: Application
    Filed: February 9, 2018
    Publication date: August 9, 2018
    Inventors: Jason Holder, Connor McBrine, Miles Rogers, Nicole Billings, Sarah Gruska, Lucas Tilley
  • BACTERIOPHAGE ENGINEERING METHODS
    Publication number: 20170283779
    Abstract: The present disclosure provides methods and kits for generating recombinant bacteriophage genomes.
    Type: Application
    Filed: March 27, 2017
    Publication date: October 5, 2017
    Applicant: The Charles Stark Draper Laboratory, Inc.
    Inventors: JASON HOLDER, Connor McBrine, Sarah Gruszka, Miles Rogers, Nicole Billings