Abstract: The present invention relates to a method for producing an amorphous solid dispersion of at least one active pharmaceutical ingredient in a polymer matrix. The Invention further relates to a pharmaceutical composition using polymers as an excipient and particularly to an improved pharmaceutical composition comprising polyvinyl alcohol grades with different degrees of hydrolysis, which is suitable to stabilize active pharmaceutical ingredients.

Abstract: The present invention relates to pharmaceutical compositions using polymers as an excipient. Particularly, the invention relates to a pharmaceutical composition comprising polyvinyl alcohol which is suitable to enhance solubility of poorly soluble active pharmaceutical ingredients in aqueous media. The present invention also relates to a method for enhancing solubility of poorly soluble active pharmaceutical ingredients.

Abstract: The present invention relates to the use of spray-dried sorbitol, such as Parteck® SI, as plasticizer for polymer containing compositions processed by (hot) melt extrusion. Due to its improved properties, achieved by its special manufacturing process (spray drying), this direct compressible excipient shows more additional benefits than the same substance in crystalline state.

Abstract: An extrudable polyvinyl alcohol (PVA) powder with improved flowability containing particles of PVA, which has been cryo-milled, and which has d50 particle sizes in the range of 45 to 1400 ?m; or which has a particle size distribution of d10=20±10 ?m, d20=30±10 ?m, d50=70±10 ?m, d90=200±30 ?m, and d99=300±30 ?m; and a powdery composition for the preparation of pharmaceutical formulations which contains the polyvinyl alcohol homogeneously mixed with at least one active pharmaceutical ingredient (API); and a process for producing a solid pharmaceutical dosage form by extruding or forming a homogeneous melt of a mixture of ingredients containing the powdered polyvinyl alcohol and at least one active pharmaceutical ingredient (API), and forming a powder or a molded form.

Abstract: The present invention relates to the use of an amino sugar as plasticizer in formulations comprising a polymer as carrier for active ingredients, in particular for compositions which are intensively mixed by treatment in a melt extrusion and then formulated by suitable post-treatment.

Abstract: The present invention relates to the use of spray-dried sorbitol, such as Parteck® SI, as plasticizer for polymer containing compositions processed by (hot) melt extrusion. Due to its improved properties, achieved by its special manufacturing process (spray drying), this direct compressible excipient shows more additional benefits than the same substance in crystalline state.

Abstract: The present invention relates to an improved powdered extrudate based on polyvinyl alcohol (PVA), which can be used for the production of pharmaceutical products, and due to its improved properties, can be better directly compressed into tablets. Furthermore, this invention refers to pharmaceutical tablets composition comprising extruded polyvinyl alcohol as carrier matrix, which is suitable to improve the solubility of API within a controlled release (instant or sustained) kinetic.

Abstract: The present invention relates to the use of an amino sugar as plasticizer in formulations comprising a polymer as carrier for active ingredients, in particular for compositions which are intensively mixed by treatment in a melt extrusion and then formulated by suitable post-treatment.

Abstract: The present invention relates to an improved powdered polyvinyl alcohol (PVA), which can be used for pharmaceutical products, and that due to its improved properties can be better dosed during formulation processes.