Patents by Inventor Nicole Evelyn Barnhardt

Nicole Evelyn Barnhardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imaging of myelin basic protein
    Patent number: 8617515
    Abstract: The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the agent, and determining myelination in the subject by detecting binding to myelin basic protein. Methods for the detection of myelin and a quantitative measurement of its local concentration in a sample using an agent with specific binding to myelin basic protein are also provided as is a kit containing the agent or its derivatives for use in detecting myelin basic protein.
    Type: Grant
    Filed: June 4, 2009
    Date of Patent: December 31, 2013
    Assignee: General Electric Company
    Inventors: Cristina Abucay Tan Hehir, Tiberiu Mircea Siclovan, Nicole Evelyn Barnhardt, Kenneth Michael Fish, Randall Lee Carter, Bruce Fletcher Johnson
  • Annulus fibrosus detection in intervertebral discs using molecular imaging agents
    Patent number: 8357350
    Abstract: The present invention relates to methods for imaging annulus fibrosus tissue and a quantitative measurement of its local concentration in a sample using an agent comprising the compound of Formula I, a 13C or 2H enriched compound of Formula I, an 19F-labeled derivative of Formula I, a metal-DOTA (1,4,7,10-tetra-azacyclododecane-N,N?,N?,N??-tetraacetic acid) complex of Formula I, or a radioisotope derivative of Formula I.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: January 22, 2013
    Assignee: General Electric Company
    Inventors: Cristina Abucay Tan Hehir, Tiberiu Mircea Siclovan, Kenneth Michael Fish, Nicole Evelyn Barnhardt, John V. Frangioni, Carrie S. Vooght
  • IMAGING OF MYELIN BASIC PROTEIN
    Publication number: 20100310457
    Abstract: The present invention relates to methods for myelin basic protein detection comprises identifying a subject at risk of or diagnosed with a myelin-associated neuropathy, parenterally administering to the subject the agent, and determining myelination in the subject by detecting binding to myelin basic protein.
    Type: Application
    Filed: June 4, 2009
    Publication date: December 9, 2010
    Applicant: GENERAL ELECTRIC COMPANY
    Inventors: Cristina Abucay Tan Hehir, Tiberiu Mircea Siclovan, Nicole Evelyn Barnhardt, Kenneth Michael Fish, Randall Lee Carter, Bruce Fletcher Johnson
  • ANNULUS FIBROSUS DETECTION IN INTERVERTEBRAL DISCS USING MOLECULAR IMAGING AGENTS
    Publication number: 20100202965
    Abstract: The present invention relates to methods for imaging annulus fibrosus tissue and a quantitative measurement of its local concentration in a sample using an agent comprising the compound of Formula I, a 13C or 2H enriched compound of Formula I, an 19F-labeled derivative of Formula I, a metal-DOTA (1,4,7,10-tetra-azacyclododecane-N,N?,N?,N??-tetraacetic acid) complex of Formula I, or a radioisotope derivative of Formula I.
    Type: Application
    Filed: February 12, 2009
    Publication date: August 12, 2010
    Applicant: General Electric Company
    Inventors: Cristina Abucay Tan Hehir, Tiberiu Mircea Siclovan, Kenneth Michael Fish, Nicole Evelyn Barnhardt, John V. Frangioni, Carrie S. Vooght