Patents by Inventor Nicole Glaser

Nicole Glaser has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Tubulysins, method for producing the same and tubulysin preparations
    Patent number: 7754885
    Abstract: The invention relates to a compound of the following general formula (tubulysin) having the following meanings for R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, S, T, U, V, W, X, Y and Z: R=H, alkyl, aryl, OR1, NR1R2 or R1=H, C1-6alkyl or aryl R2=H, C1-6alkyl or aryl S=H, Hal, NO2 or NHR3 U=H, Hal, NO2 or NHR3 R3=H, HCO or C1-4alkyl-CO T=H or OR4 R4=H, C1-4alkyl, aryl, COR5, P(O)(OR6)2 or SO3R6 R5=C1-6alkyl, alkenyl, aryl or heteroaryl R6=H, alkyl or a metal ion V=H, OR7, Hal or (for W=O) O R7=H, C1-4alkyl or COR8 R5=C1-4alkyl, alkenyl or aryl W=H or C1-4alkyl or (for V=O) O X=H, C1-4alkyl, alkenyl or CH2OR9 R9=H, C1-4alkyl, alkenyl, aryl or COR10 R10=C1-6alkyl, alkenyl, aryl or heteroaryl Y=(for Z=CH3 or COR11) free electron pair or (for Z=CH3)O R11=C1-4alkyl, CF3 or aryl and/or Z=(for Y=O or free electron pair) CH3 or (for Y=free electron pair) COR11.
    Type: Grant
    Filed: October 20, 2003
    Date of Patent: July 13, 2010
    Assignee: Helmholtz-Zentrum fuer Infektionsforschung GmbH
    Inventors: Gerhard Hoefle, Nicole Glaser, Heinrich Steinmetz, Thomas Leibold, Florenz Sasse
  • Triazolo-epothilones
    Patent number: 7419993
    Abstract: The invention relates to triazolo-thiazole analogues of epothilone A and epothilone B.
    Type: Grant
    Filed: February 9, 2005
    Date of Patent: September 2, 2008
    Assignee: Helmholtz Center of Infection Research GmbH
    Inventors: Gerhard Hoefle, Nicole Glaser
  • Tubulysins, method for producing the same and tubulysin preparations
    Publication number: 20060128754
    Abstract: The invention relates to a compound of the following general formula (tubulysin) having the following meanings for R, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, S, T, U, V, W, X, Y and Z: R=H, C1-4alkyl, aryl, OR1, NR1R2 or NH—(CH2)2-4 R1=H, C1-6alkyl or aryl R2=H, C1-6alkyl or aryl S=H, Hal, NO2 or NHR3 U=H, Hal, NO2 or NHR3 R3=H, HCO or C1-4alkyl-CO T=H or OR4 R4=H, C1-4alkyl, aryl, COR5, P(O)(OR6)2 or SO3R6 R5=C1-6alkyl, alkenyl, aryl or heteroaryl R6=H, alkyl or a metal ion V=H, OR7, Hal or (for W=O)O R7=H, C1-4alkyl or COR8 R5=C1-4alkyl, alkenyl or aryl W=H or C1-4alkyl or (for V=O) O X=H, C1-4alkyl, alkenyl or CH2OR9 R9=H, C1-4alkyl, alkenyl, aryl or COR10 R10=C1-6alkyl, alkenyl, aryl or heteroaryl Y=(for Z=CH3 or COR11) free electron pair or (for Z=CH3)O R11=C1-4alkyl, CF3 or aryl and/or Z=(for Y=O or free electron pair) CH3 or (for Y=free electron pair) COR11.
    Type: Application
    Filed: October 20, 2003
    Publication date: June 15, 2006
    Inventors: Gerhard Hoefle, Nicole Glaser, Heinrich Steinmetz, Thomas Leibold, Florenz Sasse
  • Triazolo-epothilones
    Publication number: 20050137237
    Abstract: The invention relates to triazolo-thiazole analogues of epothilone A and epothilone B.
    Type: Application
    Filed: February 9, 2005
    Publication date: June 23, 2005
    Inventors: Gerhard Hoefle, Nicole Glaser
  • Triazolo-epothilones
    Patent number: 6900160
    Abstract: The invention relates to triazolo-thiazole analogues of epothilone A and epothilone B.
    Type: Grant
    Filed: September 21, 2001
    Date of Patent: May 31, 2005
    Assignee: Gesellschaft fuer Biotechnologische Forschung mbH
    Inventors: Gerhard Hoefle, Nicole Glaser
  • Triazolo-epothilones
    Publication number: 20040014982
    Abstract: The invention relates to triazolo-thiazole analogues of epothilone A and epothilone B.
    Type: Application
    Filed: August 18, 2003
    Publication date: January 22, 2004
    Inventors: Gerhard Hoefle, Nicole Glaser
  • C-21 modified epothilones
    Patent number: 6262094
    Abstract: The invention is concerned with epothilones in which the thiazole substituent has been modified, with methods for their preparation and with antifungal or therapeutic agents which contain these epothilones.
    Type: Grant
    Filed: February 17, 2000
    Date of Patent: July 17, 2001
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gerhard Hoefle, Nicole Glaser, Thomas Leibold, Gregory Vite, Soong-Hoon Kim