Abstract: A DNA-based nanosensor system performs photoacoustic detection of cytokines. Cytokine receptors and a photoacoustic reporter dye are used in the nanosensor for cytokine detection, which can be reversible, and can be performed continuously, in vivo, in real time. Upon receptor binding to the cytokine, the DNA structure of the nanosensor closes to induce controlled dye stacking for photoacoustic application/interrogation, resulting in an increase in photoacoustic signal in the presence of the detected cytokine. The open or closed state of the sensor can be determined through differential signals as detected with photoacoustic imaging. A system using the nanosensor performs simultaneous multiplexed cytokine imaging, in the form of an inline and removable system paired with a clinical photoacoustic instrument. Cytokines can be detected in animal research use and in human point-of-care use.

Abstract: The present invention relates to a process for the preparation of bis-indolic compounds, and the bis-indolic compounds produced by the process.

Abstract: The present invention relates to a process for the preparation of bis-indolic compounds, and the bis-indolic compounds produced by the process.

Abstract: The invention relates to new chemical compounds.They are compounds corresponding to formula Ia. ##STR1## in which: R'.sub.3 represents a hydrogen atom or a hydroxy radical; R'.sub.5 represents a hydrogen atom or a hydroxy radical; or R'.sub.3 and R'.sub.5 together represent an epoxy bridge or a double bond; R".sub.5 represents a hydrogen atom or an ethyl radical; R'.sub.7 and R'.sub.8 are the same or different and represent a hydrogen atom or a methyl, hydroxymethylene, alkoxymethylene, aryloxymethylene, aminomethylene, monoalkyl or dialkyl aminomethylene, acylmethylene, arylaminomethylene, hydroxyethyl aminomethylene, alkylthiomethylene, aryloxythiomethylene or cyanomethylene radical; R.sub.1 represents a hydrogen atom or an alkyl, formyl or acyl radical: R.sub.2 represents a hydrogen atom or an alkoxy radical; R.sub.7 represents an alkanoyloxy radical, the broken line representing an optional double bond.These compounds can be used as drugs.

Abstract: A process for the preparation of a compound of formula (V) and salts thereof ##STR1## wherein R.sub.1 is selected from the group consisting of a hydrogen atom, an alkyl radical, a formyl radical and an acyl radical;R.sub.2 is selected from the group consisting of an alkoxycarbonyl radical, a hydrazide radical, an acetamido radical, a hydroxymethyl radical, and an alkanoyloxy methyl radicalandR.sub.3 and R.sub.4 are the same or different and each is selected from the group consisting of a hydrogen atom, a hydroxyl radical and an alkanoyloxyl radical;which comprises the step of treating a compound of formula IV ##STR2## wherein R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are as previously defined with at least one oxidising agent selected from the group consisting of oxidising metal salts, air and oxygen.The above compounds are useful due to their antitumoral activity, and to their use as intermediates of other antitumor drugs.

Abstract: Compounds with antitumoral activity corresponding to the formula (I): ##STR1## wherein R'.sub.1 is a hydrogen atom or an alkoxy, acyl, formyl or haloacyl radical; R'.sub.2 is a hydrogen atom or an alkyl radical; R'.sub.3 and R".sub.3 are a hydrogen atom, hydroxyl radical or an alkanoyloxy radical, and together are a carbonyl group, and R'.sub.3 and R'.sub.5 together are an epoxy bridge or a double bond; R'.sub.4 is a hydrogen atom or an alkyloxycarbonyl, hydroxymethyl, alkanoyloxymethyl or acetamido radical; R'.sub.5 and R".sub.5 are a hydrogen atom or a hydroxyl, alkanoyloxyl, ethyl or 2-hydroxyethyl radical; R'.sub.6 is a hydrogen atom or an ethyl, 2-hydroxyethyl or acetyl radical; R.sub.1 is a hydrogen atom or an alkyl, formyl or acyl radical; R.sub.2 is a hydrogen atom or alkoxy radical; R.sub.3 is a hydrogen atom or a hydroxyl or alkanoyloxyl radical, and together with R.sub.4 is an epoxy bridge or a double bond; R.sub.4 is a hydrogen atom or a hydroxyl, alkanoyloxyl radical, and together with R.sub.

Abstract: The invention provides a process for the preparation of leurosidine or vinblastine, which comprises hydroxylating and reducing .DELTA..sup.